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<!--Based on XBRL 2.1-->
<!--Created on: 5/10/2017 12:52:20 PM-->
<!--Modified on: 5/10/2017 12:52:20 PM-->
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  <element id="mdgl_InterestPayableAndWaivedInterestRelatedPartyCurrent" name="InterestPayableAndWaivedInterestRelatedPartyCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="mdgl_InterestPayableRelatedPartyCurrent" name="InterestPayableRelatedPartyCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="mdgl_InterestPayableWaivedRelatedPartyCurrent" name="InterestPayableWaivedRelatedPartyCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="mdgl_RelatedPartyTransactionsDebtConversionConvertedInstrumentAmount" name="RelatedPartyTransactionsDebtConversionConvertedInstrumentAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="mdgl_NumberOfSharesIssuedForEachShareOfAcquiredEntity" name="NumberOfSharesIssuedForEachShareOfAcquiredEntity" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="mdgl_SyntaPharmaceuticalsCorpMember" name="SyntaPharmaceuticalsCorpMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="mdgl_StockholdersMember" name="StockholdersMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="mdgl_ReverseMergerAgreementAbstract" name="ReverseMergerAgreementAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="mdgl_RemainingSecuritiesUnderShelfRegistrationValue" name="RemainingSecuritiesUnderShelfRegistrationValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>





