0001157601
us-gaap:CommonStockMember
us-gaap:SubsequentEventMember
us-gaap:OverAllotmentOptionMember
snta:PublicOfferingMember
2015-04-01
2015-04-30
0001157601
snta:LargestShareholderMembersOfBoardOfDirectorsAndEntitiesAffiliatedWithDirectorsMember
us-gaap:CommonStockMember
us-gaap:SubsequentEventMember
snta:PublicOfferingMember
2015-04-01
2015-04-30
0001157601
us-gaap:CommonStockMember
us-gaap:SubsequentEventMember
snta:PublicOfferingMember
2015-04-30
0001157601
snta:EmployeeAndDirectorsStockOptionsMember
2014-12-31
0001157601
snta:StockPlan2006Member
2015-03-31
0001157601
snta:StockPlan2006Member
2015-01-31
0001157601
snta:StockPlan2006Member
2014-12-31
0001157601
us-gaap:RestrictedStockMember
2014-12-31
0001157601
snta:EmployeeAndDirectorsStockOptionsMember
snta:StockPlan2006Member
us-gaap:MaximumMember
2015-01-01
2015-03-31
0001157601
snta:GeneralElectricCapitalCorporationTermLoanMember
2013-03-31
0001157601
us-gaap:LeaseholdImprovementsMember
2015-03-31
0001157601
us-gaap:FurnitureAndFixturesMember
2015-03-31
0001157601
us-gaap:EquipmentMember
2015-03-31
0001157601
snta:ComputersAndSoftwareMember
2015-03-31
0001157601
us-gaap:LeaseholdImprovementsMember
2014-12-31
0001157601
us-gaap:FurnitureAndFixturesMember
2014-12-31
0001157601
us-gaap:EquipmentMember
2014-12-31
0001157601
snta:ComputersAndSoftwareMember
2014-12-31
0001157601
us-gaap:CommonStockMember
us-gaap:SubsequentEventMember
snta:PublicOfferingMember
2015-04-01
2015-04-30
0001157601
snta:GeneralElectricCapitalCorporationTermLoanMember
2013-03-01
2013-03-31
0001157601
snta:OxfordFinanceCorporationTermLoanMember
2011-03-01
2011-03-31
0001157601
snta:OxfordFinanceCorporationTermLoanMember
2012-12-01
2013-06-30
0001157601
snta:OxfordFinanceCorporationTermLoanMember
2014-01-01
2014-03-31
0001157601
us-gaap:RestrictedStockMember
2015-03-31
0001157601
snta:EmployeeAndDirectorsStockOptionsMember
2015-03-31
0001157601
snta:OxfordFinanceCorporationTermLoanMember
2015-01-01
2015-03-31
0001157601
snta:OxfordFinanceCorporationTermLoanMember
2015-03-31
0001157601
snta:GeneralElectricCapitalCorporationTermLoanMember
2015-03-31
0001157601
snta:CorporateDebtSecuritiesDueWithinThreeMonthsMember
us-gaap:FairValueInputsLevel2Member
us-gaap:EstimateOfFairValueFairValueDisclosureMember
2015-03-31
0001157601
snta:CashAndMoneyMarketFundsMember
us-gaap:FairValueInputsLevel1Member
us-gaap:EstimateOfFairValueFairValueDisclosureMember
2015-03-31
0001157601
snta:CorporateDebtSecuritiesDueWithinThreeMonthsMember
us-gaap:CarryingReportedAmountFairValueDisclosureMember
2015-03-31
0001157601
snta:CashAndMoneyMarketFundsMember
us-gaap:CarryingReportedAmountFairValueDisclosureMember
2015-03-31
0001157601
us-gaap:EstimateOfFairValueFairValueDisclosureMember
2015-03-31
0001157601
us-gaap:CarryingReportedAmountFairValueDisclosureMember
2015-03-31
0001157601
snta:CorporateDebtSecuritiesDueWithinThreeMonthsMember
us-gaap:FairValueInputsLevel2Member
us-gaap:EstimateOfFairValueFairValueDisclosureMember
2014-12-31
0001157601
snta:CashAndMoneyMarketFundsMember
us-gaap:FairValueInputsLevel1Member
us-gaap:EstimateOfFairValueFairValueDisclosureMember
2014-12-31
0001157601
snta:CorporateDebtSecuritiesDueWithinThreeMonthsMember
us-gaap:CarryingReportedAmountFairValueDisclosureMember
2014-12-31
0001157601
snta:CashAndMoneyMarketFundsMember
us-gaap:CarryingReportedAmountFairValueDisclosureMember
2014-12-31
0001157601
us-gaap:EstimateOfFairValueFairValueDisclosureMember
2014-12-31
0001157601
us-gaap:CarryingReportedAmountFairValueDisclosureMember
2014-12-31
0001157601
2014-03-31
0001157601
2013-12-31
0001157601
us-gaap:CorporateDebtSecuritiesMember
2015-03-31
0001157601
us-gaap:CorporateDebtSecuritiesMember
2014-12-31
0001157601
us-gaap:FairValueInputsLevel2Member
us-gaap:EstimateOfFairValueFairValueDisclosureMember
us-gaap:CorporateDebtSecuritiesMember
2015-03-31
0001157601
us-gaap:CarryingReportedAmountFairValueDisclosureMember
us-gaap:CorporateDebtSecuritiesMember
2015-03-31
0001157601
us-gaap:FairValueInputsLevel2Member
us-gaap:EstimateOfFairValueFairValueDisclosureMember
us-gaap:CorporateDebtSecuritiesMember
2014-12-31
0001157601
us-gaap:CarryingReportedAmountFairValueDisclosureMember
us-gaap:CorporateDebtSecuritiesMember
2014-12-31
0001157601
us-gaap:RestrictedStockMember
2015-01-01
2015-03-31
0001157601
snta:EmployeeAndDirectorsStockOptionsMember
2015-01-01
2015-03-31
0001157601
us-gaap:RestrictedStockMember
2014-01-01
2014-03-31
0001157601
snta:EmployeeAndDirectorsStockOptionsMember
2014-01-01
2014-03-31
0001157601
us-gaap:RestrictedStockMember
2015-01-01
2015-03-31
0001157601
us-gaap:ResearchAndDevelopmentExpenseMember
2015-01-01
2015-03-31
0001157601
us-gaap:GeneralAndAdministrativeExpenseMember
2015-01-01
2015-03-31
0001157601
snta:EmployeeAndDirectorsStockOptionsMember
2015-01-01
2015-03-31
0001157601
us-gaap:RestrictedStockMember
2014-01-01
2014-03-31
0001157601
us-gaap:ResearchAndDevelopmentExpenseMember
2014-01-01
2014-03-31
0001157601
us-gaap:GeneralAndAdministrativeExpenseMember
2014-01-01
2014-03-31
0001157601
snta:EmployeeAndDirectorsStockOptionsMember
2014-01-01
2014-03-31
0001157601
snta:AtTheMarketIssuanceSalesAgreementMember
2014-07-01
2014-09-30
0001157601
snta:StockPlan2006Member
2015-01-01
2015-01-31
0001157601
snta:MLVAndCoLLCMember
us-gaap:MaximumMember
snta:AtTheMarketIssuanceSalesAgreementMember
2015-01-01
2015-03-31
0001157601
snta:LicenseArrangementMember
2014-05-31
0001157601
us-gaap:CorporateDebtSecuritiesMember
us-gaap:MaximumMember
2015-01-01
2015-03-31
0001157601
us-gaap:CorporateDebtSecuritiesMember
us-gaap:MaximumMember
2014-01-01
2014-12-31
0001157601
snta:CorporateDebtSecuritiesDueWithinThreeMonthsMember
us-gaap:MaximumMember
2015-01-01
2015-03-31
0001157601
snta:CorporateDebtSecuritiesDueWithinThreeMonthsMember
us-gaap:MaximumMember
2014-01-01
2014-12-31
0001157601
snta:GeneralElectricCapitalCorporationTermLoanMember
2014-01-01
2014-03-31
0001157601
2014-01-01
2014-03-31
0001157601
snta:OxfordFinanceCorporationTermLoanMember
2014-04-01
2014-04-30
0001157601
snta:OxfordFinanceCorporationTermLoanMember
2012-01-01
2012-12-31
0001157601
snta:GeneralElectricCapitalCorporationTermLoanMember
2014-01-01
2014-01-31
0001157601
snta:GeneralElectricCapitalCorporationTermLoanMember
2012-07-01
2013-03-31
0001157601
snta:OxfordFinanceCorporationTermLoanMember
2011-05-01
2011-05-31
0001157601
snta:GeneralElectricCapitalCorporationTermLoanMember
2015-01-01
2015-03-31
0001157601
snta:GeneralElectricCapitalCorporationTermLoanMember
us-gaap:MaximumMember
2015-01-01
2015-03-31
0001157601
snta:OxfordFinanceCorporationTermLoanMember
us-gaap:MinimumMember
2015-01-01
2015-03-31
0001157601
snta:OxfordFinanceCorporationTermLoanMember
us-gaap:MaximumMember
2012-12-31
0001157601
snta:AtTheMarketIssuanceSalesAgreementMember
2015-01-01
2015-03-31
0001157601
snta:AtTheMarketIssuanceSalesAgreementMember
2014-07-01
2014-07-31
0001157601
2015-03-31
0001157601
2014-12-31
0001157601
2015-05-01
0001157601
2015-01-01
2015-03-31
iso4217:USD
xbrli:shares
xbrli:pure
snta:item
snta:payment
snta:Vote
iso4217:USD
xbrli:shares
false
--12-31
Q1
2015
2015-03-31
10-Q
0001157601
134420670
Yes
Accelerated Filer
SYNTA PHARMACEUTICALS CORP
12317000
12511000
6177000
5408000
12000
11000
8000
5000
50000000
27000000
1
600000
2000000
4000000
788000
36
9
30
36
2000000
2081000
194000
100000
100000
P3M
P3M
P1Y
P1Y
2
1
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">7) Other Accrued Liabilities</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Other accrued liabilities as of March 31, 2015 and December 31, 2014 consisted of the following (in thousands):</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:65.44%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">March 31,</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">December 31,</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;"> 2014</font></p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.44%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:65.44%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Compensation and benefits</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,605
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3,852
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:65.44%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Professional fees</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,696
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,285
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:65.44%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Other</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,107
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,040
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.44%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"></font><font style="display: inline;"></font><font style="display: inline;"></font><font style="display: inline;"></font><font style="display: inline;"></font><font style="display: inline;"></font><font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5,408
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6,177
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
0.03
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Other accrued liabilities as of March 31, 2015 and December 31, 2014 consisted of the following (in thousands):</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 86.00%;margin-left:0pt;">
<tr>
<td valign="top" style="width:65.44%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;height:1.00pt;padding:0pt;">
<p style="margin:0pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;height:1.00pt;padding:0pt;">
<p style="margin:0pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;height:1.00pt;padding:0pt;">
<p style="margin:0pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
</p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;height:1.00pt;padding:0pt;">
<p style="margin:0pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
</p>
</td>
<td valign="bottom" style="width:02.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;height:1.00pt;padding:0pt;">
<p style="margin:0pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;height:1.00pt;padding:0pt;">
<p style="margin:0pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
</p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;height:1.00pt;padding:0pt;">
<p style="margin:0pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;height:1.00pt;padding:0pt;">
<p style="margin:0pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.44%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">March 31,</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">December 31,</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;"> 2014</font></p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.44%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:65.44%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Compensation and benefits</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,605
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3,852
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:65.44%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Professional fees</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,696
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,285
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:65.44%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Other</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,107
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,040
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.44%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"></font><font style="display: inline;"></font><font style="display: inline;"></font><font style="display: inline;"></font><font style="display: inline;"></font><font style="display: inline;"></font><font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5,408
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6,177
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="5" valign="bottom" style="width:36.32%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Three Months</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2014</font></p>
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Stock-based compensation expense by type of award:</font></p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.32%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Employee stock options </font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.48%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.00%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,508
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.46%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.04%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,529
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Restricted stock </font></p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>202
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>57
</td>
<td valign="bottom" style="width:01.32%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total stock-based compensation expense </font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.48%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,710
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.46%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,586
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;border-top:2pt double #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;border-top:2pt double #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.32%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Effect of stock-based compensation expense by line item:</font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Research and development </font></p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.48%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.00%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>981
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.46%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.04%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,131
</td>
<td valign="bottom" style="width:01.32%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">General and administrative </font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>729
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,455
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total stock-based compensation expense included in net loss </font></p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.48%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,710
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.46%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,586
</td>
<td valign="bottom" style="width:01.32%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
1300000
0.05
4.05
3139000
3738000
1285000
1696000
20483000
20652000
4000
6000
702694000
704403000
2586000
2529000
1455000
1131000
57000
1710000
1508000
729000
981000
202000
8179958
35000
10123204
734758
100675000
79392000
99346000
77973000
51662000
51666000
43345000
43351000
12000
11000
8000
5000
51666000
43351000
42000
42000
43000
33000
48490000
52034000
46024000
33255000
46024000
46024000
45004000
1020000
45004000
1020000
33255000
33255000
21720000
11535000
21720000
11535000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Cash and Cash Equivalents</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company considers all highly liquid investments with original maturities of three months or less at the date of purchase and an investment in a money market fund to be cash equivalents. Changes in the level of cash and cash equivalents may be affected by changes in investment portfolio maturities, as well as actual cash disbursements to fund operations.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The primary objective of the Company’s investment activities is to preserve its capital for the purpose of funding operations and the Company does not enter into investments for trading or speculative purposes. The Company’s cash is deposited in a highly rated financial institution in the United States. The Company invests in money market funds and high-grade, short-term commercial paper and corporate bonds, which management believes are subject to minimal credit and market risk. Declines in interest rates, however, would reduce future investment income.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:3pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">(3) Cash, Cash Equivalents and Marketable Securities</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">A summary of cash, cash equivalents and available-for-sale marketable securities held by the Company as of March 31, 2015 and December 31, 2014 was as follows in thousands (see Note 2):</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="11" valign="bottom" style="width:47.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">March 31, 2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Cost</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Unrealized</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">gains</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Unrealized</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">losses</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Fair</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">value</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Cash and cash equivalents:</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Cash and money market funds (Level 1) </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>21,720
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>21,720
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Corporate debt securities due within 3 months of date of purchase (Level 2) </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11,535
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11,535
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total cash and cash equivalents </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>33,255
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>33,255
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Marketable securities:</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Corporate debt securities due within 1 year of date of purchase (Level 2) </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>43,345
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(5
</td>
<td valign="bottom" style="width:02.50%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>43,351
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total cash, cash equivalents and marketable securities </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>76,600
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(5
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>76,606
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="11" valign="bottom" style="width:47.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">December 31, 2014</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Cost</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Unrealized</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">gains</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Unrealized</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">losses</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Fair</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">value</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Cash and cash equivalents:</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Cash and money market funds (Level 1) </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>45,004
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>45,004
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Corporate debt securities due within 3 months of date of purchase (Level 2) </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,020
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,020
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total cash and cash equivalents </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>46,024
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>46,024
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Marketable securities:</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Corporate debt securities due within 1 year of date of purchase (Level 2) </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>51,662
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>12
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(8
</td>
<td valign="bottom" style="width:02.50%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>51,666
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total cash, cash equivalents and marketable securities </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>97,686
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>12
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(8
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>97,690
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
97686000
97690000
76600000
76606000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">(8) Co-Development and License Agreements</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;font-style:italic;">Co-Development Agreement</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In July 2011, the Company entered into a co-development agreement with a clinical research organization (CRO) for the conduct of certain company-sponsored clinical trials. Under the co-development agreement, this CRO was performing clinical research services under a reduced fee structure in exchange for a share of licensing payments and commercial revenues, if any, resulting from the product under development up to a specified maximum payment, which is defined as a multiple of the fee reduction realized. Research and development expenses were being recognized based on the reduced fee structure and expected payments will be recorded in the future if and when payment is probable. The maximum amount of the service fee discount was realized in the year ended December 31, 2013.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;font-style:italic;">License Arrangement</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In May 2014, the Company entered into a license arrangement for its CRACM program, including two lead candidates and the associated intellectual property portfolio, with PRCL Research Inc. (PRCL), a company funded by TVM Life Science Venture VII and the Fonds de Solidarité des Travailleurs du Québec, based in Montreal, Canada. PRCL plans to develop one of the two lead candidates licensed from the Company to proof-of-concept. Synta was granted a minority interest in PRCL in exchange for its contribution of know-how and intellectual property and will also hold a seat on PRCL’s Board of Directors. Synta will not be required to provide any research funding or capital contributions to PRCL. Synta will be reimbursed by PRCL for any ongoing intellectual property management costs in connection with the contributed intellectual property and may conduct preclinical research activities which would be reimbursed by PRCL. If and when proof-of-concept is reached with either drug candidate, Eli Lilly and Company, which is an investor in TVM, will manage the development program through one of its divisions and will have an option to acquire PRCL or its assets at the then fair value.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
0.0001
0.0001
200000000
200000000
109120670
109120670
109120670
109120670
11000
11000
-23570000
-20705000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Comprehensive Loss</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Comprehensive loss is defined as the change in equity of a business enterprise during a period from transactions and other events and circumstances from non-owner sources. Changes in unrealized gains and losses on marketable securities represent the only difference between the Company’s net loss and comprehensive loss.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;text-indent:11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Principles of Consolidation</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The condensed consolidated financial statements include the financial statements of the Company and its wholly owned subsidiaries. All significant intercompany balances and transactions have been eliminated in consolidation.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">(9) Term Loans</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;font-style:italic;">General Electric Capital Corporation</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In March 2013, the Company amended its loan and security agreement entered into in September 2010 with General Electric Capital Corporation (GECC) and another lender (the GECC Term Loan) and obtained $12.9 million in additional loan funding and, as a result, increased the principal balance to $22.5 million at March 31, 2013. This amendment was accounted for as a loan modification. Interest on the borrowings under the GECC Term Loan remains at the annual rate of 9.75%. In January 2014, the Company began making 30 equal monthly payments of principal plus accrued interest on the outstanding balance. During the period from July 2012 through March 2013, the Company made nine equal monthly payments of principal under the GECC Term Loan. For the periods from April 2013 through December 2013 and prior to July 2012 the Company made interest-only payments.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company has paid various transaction fees and expenses in connection with the GECC Term Loan, which are deferred and are being amortized as interest expense over the remaining term of the GECC Term Loan. In addition, the Company is obligated to pay an exit fee of $788,000 at the time of the final principal payment which is being accreted and expensed as interest over the remaining term of the GECC Term Loan. In the three months ended March 31, 2015 and 2014, the Company recognized GECC Term Loan interest expense of $0.4 million and $0.6 million, respectively, of which $0.1 million was in connection with these transaction and exit fees and expenses in each of the periods. The Company may prepay the full amount of the GECC Term Loan, subject to prepayment premiums under certain circumstances. The Company did not issue any warrants in connection with the GECC Term Loan.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The GECC Term Loan is secured by substantially all of the Company’s assets, except its intellectual property. The Company has granted GECC a springing security interest in its intellectual property in the event the Company is not in compliance with certain cash usage covenants, as defined therein. The GECC Term Loan contains restrictive covenants, including the requirement for the Company to receive the prior written consent of GECC to enter into loans, other than up to $4.0 million of equipment financing, restrictions on the declaration or payment of dividends, restrictions on acquisitions, and customary default provisions that include material adverse events, as defined therein. The Company has determined that the risk of subjective acceleration under the material adverse events clause is remote and therefore has classified the outstanding principal in current and long-term liabilities based on the timing of scheduled principal payments.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;font-style:italic;">Oxford Finance Corporation</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In March 2011, the Company entered into a loan and security agreement with Oxford Finance Corporation (Oxford) and received $2.0 million in loan funding, and in December 2012, the Company entered into a loan modification agreement, as amended, under which the Company could elect to draw down up to an additional $0.6 million in equipment financing until June 30, 2013 that would be payable in 36 equal monthly payments of principal plus accrued interest on the outstanding balance (collectively, the Oxford Term Loan). As of June 30, 2013, the Company had fully utilized the $0.6 million in additional equipment financing. Interest on the borrowings under the Oxford Term Loan accrues at an annual rate of 13.35%. In May 2011, the Company began making 36 equal monthly payments of principal plus accrued interest on the initial $2.0 million outstanding balance that was fully paid in April 2014. The Company continues to make equal monthly payments of principal plus accrued interest on the $0.6 million in additional equipment financing. The Company recognized approximately $13,000 and $20,000 in interest expense in the three months ended March 31, 2015 and 2014, respectively, related to the outstanding principal under the Oxford Term Loan. In addition to the interest payable under the Oxford Term Loan, the Company paid approximately $108,000 of administrative and legal fees and expenses in connection with the Oxford Term Loan. These expenses have been deferred and are being expensed over the term of the Oxford Term Loan. The Company did not issue any warrants in connection with the Oxford Term Loan. The Company may prepay the Oxford Term Loan, subject to prepayment premiums under certain circumstances. Oxford has the right to require the Company to prepay the Oxford Term Loan if the Company prepays the full amount of the GECC Term Loan under certain circumstances.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Oxford Term Loan is secured by certain laboratory and office equipment, furniture and fixtures. In connection with the Oxford Term Loan, Oxford and GECC entered into a Lien Subordination Agreement, whereby GECC granted Oxford a first priority perfected security interest in the loan collateral. The Oxford Term Loan contains restrictive covenants, including the requirement for the Company to receive the prior written consent of Oxford to enter into acquisitions in which the Company incurs more than $2.0 million of related indebtedness, and customary default provisions that include material adverse events, as defined therein. The Company has determined that the risk of subjective acceleration under the material adverse events clause is remote and therefore has classified the outstanding principal in current and long-term liabilities based on the timing of scheduled principal payments.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:56pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Future principal payments under the GECC and Oxford Term Loans as of March 31, 2015 were approximately as follows (in thousands):</font>
</p>
<p style="margin:0pt;text-indent:30.8pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="top" style="width:82.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Years ending December 31,</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:82.14%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">2015 </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6,913
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:82.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">2016 </font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,607
</td>
<td valign="bottom" style="width:01.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:82.14%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total principal payments </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11,520
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:82.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Less current portion </font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(9,221
</td>
<td valign="bottom" style="width:01.14%;background-color: #CCEEFF;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:82.14%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Long term portion </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,299
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
0.0975
0.1335
108000
168000
169000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">(6) Stock-Based Compensation</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company’s 2006 Stock Plan provides for the grant of incentive stock options, non-statutory stock options and non-vested restricted stock to employees, officers, directors and consultants of the Company. In January 2015, the number of shares of common stock reserved for issuance under the 2006 Stock Plan was increased from 10,300,000 to 11,600,000 pursuant to an “evergreen” provision, which provides for an annual increase based on the lesser of 1,300,000 shares, 5% of the Company’s then outstanding shares of common stock, or such other amount as the board of directors may determine. This increase was approved by the board of directors in December 2014. The administration of the 2006 Stock Plan is under the general supervision of the compensation committee of the board of directors. The exercise price of the stock options is determined by the compensation committee of the board of directors, provided that incentive stock options are granted with an exercise price not less than fair market value of the common stock on the date of grant and expire no later than ten years from the date the option is granted. Options generally vest over four years. As of March 31, 2015, the Company had options outstanding to purchase 10,123,204 shares of its common stock, which includes options outstanding under its 2001 Stock Plan that was terminated in March 2006. As of March 31, 2015, 1,261,136 shares were available for future issuance.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:44pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The following table summarizes stock option activity during the three months ended March 31, 2015:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:60.06%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Shares</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Weighted average</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">exercise price</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">per share</font></p>
</td>
<td valign="bottom" style="width:01.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Outstanding at January 1, 2015</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>8,829,343
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.38%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6.17
</td>
<td valign="bottom" style="width:01.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Options granted</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,693,686
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2.39
</td>
<td valign="bottom" style="width:01.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Options exercised</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:01.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Options cancelled</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(399,825
</td>
<td valign="bottom" style="width:02.78%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>9.14
</td>
<td valign="bottom" style="width:01.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Outstanding at March 31, 2015</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>10,123,204
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.38%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5.42
</td>
<td valign="bottom" style="width:01.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Exercisable at March 31, 2015</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:2pt double #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5,305,790
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:2pt double #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.38%;border-top:2pt double #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6.45
</td>
<td valign="bottom" style="width:01.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:24pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The total cash received by the Company as a result of stock option exercises during the three months ended March 31, 2015 and 2014 was $0 and $0.8 million, respectively. The weighted-average grant date fair values of options granted during the three months ended March 31, 2015 and 2014 were $1.92 and $5.02, respectively.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Non-Vested (“Restricted”) Stock Awards With Service Conditions</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company’s share-based compensation plan provides for awards of restricted shares of common stock to employees, officers, directors and consultants to the Company. Restricted stock awards are subject to forfeiture if employment or service terminates during the prescribed retention period. Restricted shares vest over the service period. The total fair value of restricted stock that vested in each of the three months ended March 31, 2015 and 2014 was $0.1 million.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The following table summarizes unvested restricted share activity during the three months ended March 31, 2015:</font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:60.08%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Shares</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Weighted</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">average</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">grant date</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">fair value</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">per share</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:60.08%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Outstanding at January 1, 2015</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>744,514
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.38%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3.65
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:60.08%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Vested</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(9,756
</td>
<td valign="bottom" style="width:02.78%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4.10
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:60.08%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Granted</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:60.08%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Forfeited</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:60.08%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Outstanding at March 31, 2015</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>734,758
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.38%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3.65
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Stock-Based Compensation Expense</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:29.7pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">For the three months ended March 31, 2015 and 2014, the fair value of each employee stock option award was estimated on the date of grant based on the fair value method using the Black-Scholes option pricing valuation model with the following weighted average assumptions:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:58.90%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="3" valign="bottom" style="width:35.48%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Three Months</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:02.44%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:58.90%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.14%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.16%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2014</font></p>
</td>
<td valign="bottom" style="width:02.44%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:58.90%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Risk-free interest rate </font></p>
</td>
<td valign="bottom" style="width:03.18%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.14%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1.77
</td>
<td valign="bottom" style="width:03.18%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">%</font></p>
</td>
<td valign="bottom" style="width:16.16%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1.84
</td>
<td valign="bottom" style="width:02.44%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">%</font></p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:58.90%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Expected life in years </font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.14%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6.25
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.16%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6.25
</td>
<td valign="bottom" style="width:02.44%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:58.90%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Volatility </font></p>
</td>
<td valign="bottom" style="width:03.18%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.14%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>101
</td>
<td valign="bottom" style="width:03.18%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">%</font></p>
</td>
<td valign="bottom" style="width:16.16%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>104
</td>
<td valign="bottom" style="width:02.44%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">%</font></p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:58.90%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Expected dividend yield </font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.16%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.44%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Stock-based compensation expense during the three months ended March 31, 2015 and 2014 was as follows (in thousands):</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="5" valign="bottom" style="width:36.32%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Three Months</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2014</font></p>
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Stock-based compensation expense by type of award:</font></p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.32%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Employee stock options </font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.48%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.00%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,508
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.46%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.04%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,529
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Restricted stock </font></p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>202
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>57
</td>
<td valign="bottom" style="width:01.32%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total stock-based compensation expense </font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.48%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,710
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.46%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,586
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;border-top:2pt double #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;border-top:2pt double #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.32%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Effect of stock-based compensation expense by line item:</font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Research and development </font></p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.48%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.00%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>981
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.46%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.04%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,131
</td>
<td valign="bottom" style="width:01.32%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">General and administrative </font></p>
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.48%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>729
</td>
<td valign="bottom" style="width:03.34%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,455
</td>
<td valign="bottom" style="width:01.32%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:59.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total stock-based compensation expense included in net loss </font></p>
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.48%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,710
</td>
<td valign="bottom" style="width:03.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.46%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,586
</td>
<td valign="bottom" style="width:01.32%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:30pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Unrecognized stock-based compensation expense as of March 31, 2015 was as follows (dollars in thousands):</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Unrecognized</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">stock</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">compensation</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">expense</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Weighted</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">average</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">remaining</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">period</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">(in years)</font></p>
</td>
<td valign="bottom" style="width:01.16%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Employee stock options</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>13,821
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2.79
</td>
<td valign="bottom" style="width:01.16%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Restricted stock</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,343
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3.19
</td>
<td valign="bottom" style="width:01.16%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>16,164
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2.85
</td>
<td valign="bottom" style="width:01.16%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
-0.28
-0.19
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Basic and Diluted Loss Per Common Share</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Basic net loss per share is computed using the weighted average number of common shares outstanding during the period, excluding restricted stock that has been issued but is not yet vested. Diluted net loss per common share is computed using the weighted average number of common shares outstanding and the weighted average dilutive potential common shares outstanding using the treasury stock method. However, for the three months ended March 31, 2015 and 2014, diluted net loss per share is the same as basic net loss per share as the inclusion of weighted average shares of unvested restricted common stock and common stock issuable upon the exercise of stock options would be anti-dilutive.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The following table summarizes outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="3" valign="bottom" style="width:30.58%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">March 31,</font></p>
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.86%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2014</font></p>
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Common stock options</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>10,123,204
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.86%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>8,179,958
</td>
<td valign="bottom" style="width:01.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Unvested restricted common stock</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>734,758
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.86%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>35,000
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
3852000
2605000
800000
0
16164000
13821000
2343000
P2Y10M6D
P2Y9M15D
P3Y2M9D
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Fair Value of Financial Instruments</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The carrying amounts of the Company’s financial instruments, which include cash equivalents, marketable securities and term loan obligations, approximate their fair values. The fair value of the Company’s financial instruments reflects the amounts that would be received upon sale of an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy has the following three levels:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Level 1—quoted prices in active markets for identical assets and liabilities.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Level 2—observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Level 3—unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Financial assets and liabilities are classified in their entirety within the fair value hierarchy based on the lowest level of input that is significant to the fair value measurement. The Company measures the fair value of its marketable securities by taking into consideration valuations obtained from third-party pricing sources. The pricing services utilize industry standard valuation models, including both income and market based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker-dealer quotes on the same or similar securities, issuer credit spreads, benchmark securities and other observable inputs. As of March 31, 2015, the Company’s financial assets valued based on Level 1 inputs consisted of cash and cash equivalents in a money market fund and its financial assets valued based on Level 2 inputs consisted of high-grade corporate bonds and commercial paper. During the three months ended March 31, 2015 and 2014, the Company did not have any transfers of financials assets between Levels 1 and 2. As of March 31, 2015, the Company did not have any financial liabilities that were recorded at fair value on the balance sheet. The disclosed fair value of the Company’s term loan obligations is determined using current applicable rates for similar instruments as of the balance sheet date. The carrying value of the Company’s term loan obligations approximates fair value as the Company’s interest rate yield is near current market rate yields. The disclosed fair value of the Company’s term loan obligations is based on Level 3 inputs.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
5324000
4150000
-780000
598000
-953000
-769000
-32000
259000
-153000
-289000
600000
20000
400000
13000
-650000
-375000
560000
325000
35539000
33252000
100675000
79392000
30889000
30920000
4650000
2332000
6913000
4607000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Marketable Securities</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Marketable securities consist of investments in high-grade corporate obligations, and government and government agency obligations that are classified as available-for-sale. Since these securities are available to fund current operations they are classified as current assets on the consolidated balance sheets.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company adjusts the cost of available-for-sale debt securities for amortization of premiums and accretion of discounts to maturity. The Company includes such amortization and accretion as a component of interest expense, net. Realized gains and losses and declines in value, if any, that the Company judges to be other-than-temporary on available-for-sale securities are reported as a component of interest expense, net. To determine whether an other-than-temporary impairment exists, the Company considers whether it intends to sell the debt security and, if the Company does not intend to sell the debt security, it considers available evidence to assess whether it is more likely than not that it will be required to sell the security before the recovery of its amortized cost basis. During the three months ended March 31, 2015 and 2014, the Company determined it did not have any securities that were other-than-temporarily impaired.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Marketable securities are stated at fair value, including accrued interest, with their unrealized gains and losses included as a component of accumulated other comprehensive income or loss, which is a separate component of stockholders’ equity. The fair value of these securities is based on quoted prices and observable inputs on a recurring basis. Realized gains and losses are determined on the specific identification method. During the three months ended March 31, 2015 and 2014, the Company did not have any realized gains or losses on marketable securities.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">(1) Nature of Business</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Synta Pharmaceuticals Corp. (the Company) was incorporated in March 2000 and commenced operations in July 2001. The Company is an innovative, agile biopharmaceutical company focused on research, development and commercialization of novel oncology medicines that have the potential to change the lives of cancer patients.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company is subject to risks common to emerging companies in the drug development and pharmaceutical industry including, but not limited to, uncertainty of product development and commercialization, lack of marketing and sales history, dependence on key personnel, uncertainty of market acceptance of products and product reimbursement, product liability, uncertain protection of proprietary technology, potential inability to raise additional financing and compliance with the U.S. Food and Drug Administration and other government regulations.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company may require significant additional funds earlier than it currently expects in order to conduct additional clinical trials and continue to fund its operations. There can be no assurances, however, that additional funding will be available on favorable terms, or at all. If adequate funds are not available, the Company may be required to delay, significantly modify or terminate its research and development programs or reduce its planned commercialization efforts.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
3544000
-12769000
7617000
-2311000
16197000
8317000
-20270000
-18775000
-23557000
-20707000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Recent Accounting Pronouncements</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In May 2014, the FASB issued ASU No. 2014-09, —</font><font style="display: inline;font-style:italic;">Revenue from Contracts with Customers</font><font style="display: inline;"> (Topic 606), which amends the guidance for accounting for revenue from contracts with customers. This ASU supersedes the revenue recognition requirements in ASC Topic 605, and creates a new Topic 606,</font><font style="display: inline;font-style:italic;"> Revenue from Contracts with Customers</font><font style="display: inline;">. This guidance is effective for fiscal years beginning after December 15, 2016, with early adoption not permitted. Two adoption methods are permitted: retrospectively to all prior reporting periods presented, with certain practical expedients permitted; or retrospectively with the cumulative effect of initially adopting the ASU recognized at the date of initial application. In April 2015, the FASB proposed a one year deferral of the effective date of this standard to annual periods ending after December 15, 2017, along with an option to permit companies to early adopt the standard for annual periods beginning after December 15, 2016. The Company has not yet determined which adoption method it will utilize or the effect that the adoption of this guidance will have on its consolidated financial statements.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In August 2014, the FASB issued ASU No. 2014-15, —</font><font style="display: inline;font-style:italic;">Presentation of Financial Statements—Going Concern (Subtopic 205-40): Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern</font><font style="display: inline;">. This ASU is intended to define management’s responsibility to evaluate whether there is substantial doubt about an organization’s ability to continue as a going concern within one year of the date of issuance of the entity’s financial statements and to provide related footnote disclosures. This guidance is effective for fiscal years ending after December 15, 2016, with early application permitted. The Company has not yet determined the effect that the adoption of this guidance will have on the disclosures included in its consolidated financial statements.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
22907000
20332000
-22907000
-20332000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">(2) Summary of Significant Accounting Policies</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:17pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The accompanying condensed consolidated financial statements are unaudited, have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments necessary to present fairly the Company’s financial position as of March 31, 2015 and the consolidated results of operations, comprehensive loss and cash flows for the three months ended March 31, 2015 and 2014. The preparation of financial statements in conformity with accounting principles generally accepted in the United States (GAAP) requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from these estimates. The results of operations for the three months ended March 31, 2015 are not necessarily indicative of the results to be expected for the year ending December 31, 2015 or for any other interim period or any other future year. For more complete financial information, these condensed financial statements, and the notes hereto, should be read in conjunction with the audited financial statements for the year ended December 31, 2014 included in the Company’s Annual Report on Form 10-K.</font>
</p>
<p style="margin:0pt;text-indent:11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Principles of Consolidation</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The condensed consolidated financial statements include the financial statements of the Company and its wholly owned subsidiaries. All significant intercompany balances and transactions have been eliminated in consolidation.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Use of Estimates</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The preparation of financial statements in conformity with U.S. generally accepted accounting principles (GAAP) requires management to make estimates and assumptions that affect certain reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting periods. Significant items subject to such estimates and assumptions include contract research accruals, recoverability of long-lived assets, measurement of stock-based compensation, and the periods of performance under collaborative research and development agreements. The Company bases its estimates on historical experience and various other assumptions that management believes to be reasonable under the circumstances. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Cash and Cash Equivalents</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company considers all highly liquid investments with original maturities of three months or less at the date of purchase and an investment in a money market fund to be cash equivalents. Changes in the level of cash and cash equivalents may be affected by changes in investment portfolio maturities, as well as actual cash disbursements to fund operations.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The primary objective of the Company’s investment activities is to preserve its capital for the purpose of funding operations and the Company does not enter into investments for trading or speculative purposes. The Company’s cash is deposited in a highly rated financial institution in the United States. The Company invests in money market funds and high-grade, short-term commercial paper and corporate bonds, which management believes are subject to minimal credit and market risk. Declines in interest rates, however, would reduce future investment income.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Marketable Securities</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Marketable securities consist of investments in high-grade corporate obligations, and government and government agency obligations that are classified as available-for-sale. Since these securities are available to fund current operations they are classified as current assets on the consolidated balance sheets.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company adjusts the cost of available-for-sale debt securities for amortization of premiums and accretion of discounts to maturity. The Company includes such amortization and accretion as a component of interest expense, net. Realized gains and losses and declines in value, if any, that the Company judges to be other-than-temporary on available-for-sale securities are reported as a component of interest expense, net. To determine whether an other-than-temporary impairment exists, the Company considers whether it intends to sell the debt security and, if the Company does not intend to sell the debt security, it considers available evidence to assess whether it is more likely than not that it will be required to sell the security before the recovery of its amortized cost basis. During the three months ended March 31, 2015 and 2014, the Company determined it did not have any securities that were other-than-temporarily impaired.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Marketable securities are stated at fair value, including accrued interest, with their unrealized gains and losses included as a component of accumulated other comprehensive income or loss, which is a separate component of stockholders’ equity. The fair value of these securities is based on quoted prices and observable inputs on a recurring basis. Realized gains and losses are determined on the specific identification method. During the three months ended March 31, 2015 and 2014, the Company did not have any realized gains or losses on marketable securities.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Fair Value of Financial Instruments</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The carrying amounts of the Company’s financial instruments, which include cash equivalents, marketable securities and term loan obligations, approximate their fair values. The fair value of the Company’s financial instruments reflects the amounts that would be received upon sale of an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy has the following three levels:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Level 1—quoted prices in active markets for identical assets and liabilities.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Level 2—observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Level 3—unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Financial assets and liabilities are classified in their entirety within the fair value hierarchy based on the lowest level of input that is significant to the fair value measurement. The Company measures the fair value of its marketable securities by taking into consideration valuations obtained from third-party pricing sources. The pricing services utilize industry standard valuation models, including both income and market based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker-dealer quotes on the same or similar securities, issuer credit spreads, benchmark securities and other observable inputs. As of March 31, 2015, the Company’s financial assets valued based on Level 1 inputs consisted of cash and cash equivalents in a money market fund and its financial assets valued based on Level 2 inputs consisted of high-grade corporate bonds and commercial paper. During the three months ended March 31, 2015 and 2014, the Company did not have any transfers of financials assets between Levels 1 and 2. As of March 31, 2015, the Company did not have any financial liabilities that were recorded at fair value on the balance sheet. The disclosed fair value of the Company’s term loan obligations is determined using current applicable rates for similar instruments as of the balance sheet date. The carrying value of the Company’s term loan obligations approximates fair value as the Company’s interest rate yield is near current market rate yields. The disclosed fair value of the Company’s term loan obligations is based on Level 3 inputs.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Revenue Recognition</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;font-style:italic;">Collaboration and License Agreements</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company’s principal source of revenue to date has been its former collaboration and license agreements, which included upfront license payments, development milestones, reimbursement of research and development costs, potential profit sharing payments, commercial and sales-based milestones and royalties. The accounting for collaboration and license agreements requires subjective analysis and requires management to make estimates and assumptions about whether deliverables within multiple-element arrangements are separable from the other aspects of the contractual arrangement into separate units of accounting and to determine the arrangement consideration to be allocated to each unit of accounting.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">For multiple-element arrangements entered into or materially modified after January 1, 2011, the Company follows the provisions of Financial Accounting Standards Board (FASB) Accounting Standards Update (ASU) No. 2009-13—</font><font style="display: inline;font-style:italic;"> Multiple-deliverable Revenue Arrangements</font><font style="display: inline;"> (ASU No. 2009-13). ASU No. 2009-13 amended certain provisions of Accounting Standards Codification (ASC) Topic 605—</font><font style="display: inline;font-style:italic;"> Revenue Recognition</font><font style="display: inline;">. This standard addresses the determination of the unit(s) of accounting for multiple-element arrangements and how an arrangement’s consideration should be allocated to each unit of accounting.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Pursuant to this standard, each required deliverable is evaluated to determine if it qualifies as a separate unit of accounting. For the Company this determination includes an assessment as to whether the deliverable has “stand-alone value” to the customer separate from the undelivered elements. The arrangement’s consideration is then allocated to each separate unit of accounting based on the relative selling price of each deliverable. The estimated selling price of each deliverable is determined using the following hierarchy of values: (i) vendor-specific objective evidence of fair value, (ii) third-party evidence of selling price, or (iii) the Company’s best estimate of the selling price (BESP). The BESP reflects the Company’s best estimate of what the selling price would be if the deliverable was regularly sold by it on a stand-alone basis. The Company expects, in general, to use BESP for allocating consideration to each deliverable in future collaboration agreements. In general, the consideration allocated to each unit of accounting is then recognized as the related goods or services are delivered limited to the consideration not contingent upon future deliverables. The Company did not recognize any revenue related to collaboration and license agreements during the three months ended March 31, 2015 and 2014.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company accounts for development milestones under collaboration and license agreements pursuant to ASU No. 2010-17</font><font style="display: inline;font-style:italic;">Milestone Method of Revenue Recognition</font><font style="display: inline;"> (ASU No. 2010-17). ASU No. 2010-17 codified a method of revenue recognition that has been common practice. Under this method, contingent consideration from research and development activities that is earned upon the achievement of a substantive milestone is recognized in its entirety in the period in which the milestone is achieved. At the inception of each arrangement that includes milestone payments, the Company evaluates whether each milestone is substantive. This evaluation includes an assessment of whether (a) the consideration is commensurate with either (1) the entity’s performance to achieve the milestone, or (2) the enhancement of the value of the delivered item(s) as a result of a specific outcome resulting from the entity’s performance to achieve the milestone, (b) the consideration relates solely to past performance and (c) the consideration is reasonable relative to all of the deliverables and payment terms within the arrangement. The Company evaluates factors such as the scientific, clinical, regulatory, commercial and other risks that must be overcome to achieve the respective milestone, the level of effort and investment required and whether the milestone consideration is reasonable relative to all deliverables and payment terms in the arrangement in making this assessment. The Company does not have any ongoing collaboration and license agreements under which milestones may be achieved.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Royalty revenues are based upon a percentage of net sales. Royalties from the sales of products will be recorded on the accrual basis when results are reliably measurable, collectability is reasonably assured and all other revenue recognition criteria are met. Commercial and sales-based milestones, which are based upon the achievement of certain agreed-upon sales thresholds, will be recognized in the period in which the respective sales threshold is achieved and collectability is reasonably assured. The Company does not have any ongoing collaboration and license agreements under which royalties or commercial and sales-based milestones may be achieved.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Stock-Based Compensation</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company recognizes stock-based compensation expense based on the grant date fair value of stock options granted to employees, officers and directors. The Company uses the Black-Scholes option pricing model to determine the grant date fair value as management believes it is the most appropriate valuation method for its option grants. The Black-Scholes model requires inputs for risk-free interest rate, dividend yield, volatility and expected lives of the options. Expected volatility is based upon the weighted average historical volatility data of the Company’s common stock. The risk-free rate for periods within the expected life of the option is based on the U.S. Treasury yield curve in effect at the time of the grant. The expected lives for options granted represent the period of time that options granted are expected to be outstanding. The Company uses the simplified method for determining the expected lives of options. The Company estimates the forfeiture rate based on historical data. This analysis is re-evaluated at least annually and the forfeiture rate is adjusted as necessary.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">For awards with graded vesting, the Company recognizes compensation costs based on the grant date fair value of awards on a straight-line basis over the requisite service period, which is generally the vesting period.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Certain of the employee stock options granted by the Company are structured to qualify as incentive stock options (ISOs). Under current tax regulations, the Company does not receive a tax deduction for the issuance, exercise or disposition of ISOs if the employee meets certain holding requirements. If the employee does not meet the holding requirements, a disqualifying disposition occurs, at which time the Company may receive a tax deduction. The Company does not record tax benefits related to ISOs unless and until a disqualifying disposition is reported. In the event of a disqualifying disposition, the entire tax benefit is recorded as a reduction of income tax expense. The Company has not recognized any income tax benefit for its share-based compensation arrangements due to the fact that the Company does not believe it is more likely than not it will realize the related deferred tax assets.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Comprehensive Loss</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Comprehensive loss is defined as the change in equity of a business enterprise during a period from transactions and other events and circumstances from non-owner sources. Changes in unrealized gains and losses on marketable securities represent the only difference between the Company’s net loss and comprehensive loss.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Segment Reporting</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Operating segments are determined based on the way management organizes its business for making operating decisions and assessing performance. The Company has a single operating segment, which is the discovery, development and commercialization of drug products.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Basic and Diluted Loss Per Common Share</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Basic net loss per share is computed using the weighted average number of common shares outstanding during the period, excluding restricted stock that has been issued but is not yet vested. Diluted net loss per common share is computed using the weighted average number of common shares outstanding and the weighted average dilutive potential common shares outstanding using the treasury stock method. However, for the three months ended March 31, 2015 and 2014, diluted net loss per share is the same as basic net loss per share as the inclusion of weighted average shares of unvested restricted common stock and common stock issuable upon the exercise of stock options would be anti-dilutive.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The following table summarizes outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="3" valign="bottom" style="width:30.58%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">March 31,</font></p>
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.86%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2014</font></p>
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Common stock options</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>10,123,204
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.86%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>8,179,958
</td>
<td valign="bottom" style="width:01.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Unvested restricted common stock</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>734,758
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.86%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>35,000
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Recent Accounting Pronouncements</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In May 2014, the FASB issued ASU No. 2014-09, —</font><font style="display: inline;font-style:italic;">Revenue from Contracts with Customers</font><font style="display: inline;"> (Topic 606), which amends the guidance for accounting for revenue from contracts with customers. This ASU supersedes the revenue recognition requirements in ASC Topic 605, and creates a new Topic 606,</font><font style="display: inline;font-style:italic;"> Revenue from Contracts with Customers</font><font style="display: inline;">. This guidance is effective for fiscal years beginning after December 15, 2016, with early adoption not permitted. Two adoption methods are permitted: retrospectively to all prior reporting periods presented, with certain practical expedients permitted; or retrospectively with the cumulative effect of initially adopting the ASU recognized at the date of initial application. In April 2015, the FASB proposed a one year deferral of the effective date of this standard to annual periods ending after December 15, 2017, along with an option to permit companies to early adopt the standard for annual periods beginning after December 15, 2016. The Company has not yet determined which adoption method it will utilize or the effect that the adoption of this guidance will have on its consolidated financial statements.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In August 2014, the FASB issued ASU No. 2014-15, —</font><font style="display: inline;font-style:italic;">Presentation of Financial Statements—Going Concern (Subtopic 205-40): Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern</font><font style="display: inline;">. This ASU is intended to define management’s responsibility to evaluate whether there is substantial doubt about an organization’s ability to continue as a going concern within one year of the date of issuance of the entity’s financial statements and to provide related footnote disclosures. This guidance is effective for fiscal years ending after December 15, 2016, with early application permitted. The Company has not yet determined the effect that the adoption of this guidance will have on the disclosures included in its consolidated financial statements.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
1040000
1107000
305000
564000
-13000
2000
3548000
28683000
23000
0.0001
0.0001
5000000
5000000
0
0
0
0
1656000
1367000
10118000
600000
2000000
12900000
22500000
41800000
19768000
37000000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">(4) Property and Equipment</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:52pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Property and equipment as of March 31, 2015 and December 31, 2014 consisted of the following (in thousands):</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:62.48%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.10%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">March 31,</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:03.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">December 31,</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">2014</font></p>
</td>
<td valign="bottom" style="width:01.24%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:62.48%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.10%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:03.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.24%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:62.48%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Laboratory equipment </font></p>
</td>
<td valign="bottom" style="width:03.10%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:13.68%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>12,217
</td>
<td valign="bottom" style="width:03.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:13.68%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>12,217
</td>
<td valign="bottom" style="width:01.24%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:62.48%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Leasehold improvements </font></p>
</td>
<td valign="bottom" style="width:03.10%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,988
</td>
<td valign="bottom" style="width:03.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,988
</td>
<td valign="bottom" style="width:01.24%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:62.48%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Computers and software </font></p>
</td>
<td valign="bottom" style="width:03.10%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3,126
</td>
<td valign="bottom" style="width:03.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3,126
</td>
<td valign="bottom" style="width:01.24%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:62.48%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Furniture and fixtures </font></p>
</td>
<td valign="bottom" style="width:03.10%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,176
</td>
<td valign="bottom" style="width:03.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,176
</td>
<td valign="bottom" style="width:01.24%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:62.48%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.10%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>21,507
</td>
<td valign="bottom" style="width:03.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>21,507
</td>
<td valign="bottom" style="width:01.24%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:62.48%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Less accumulated depreciation and amortization </font></p>
</td>
<td valign="bottom" style="width:03.10%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(20,652
</td>
<td valign="bottom" style="width:03.12%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(20,483
</td>
<td valign="bottom" style="width:01.24%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:62.48%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.10%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.34%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:13.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>855
</td>
<td valign="bottom" style="width:03.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.34%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:13.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,024
</td>
<td valign="bottom" style="width:01.24%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Depreciation and amortization expenses of property and equipment, including equipment purchased under capital leases, were approximately $0.2 million in each of the three months ended March 31, 2015 and 2014.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
21507000
3126000
12217000
1176000
4988000
21507000
3126000
12217000
1176000
4988000
1024000
855000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:62.48%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.10%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">March 31,</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:03.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">December 31,</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">2014</font></p>
</td>
<td valign="bottom" style="width:01.24%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:62.48%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.10%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:03.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.24%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:62.48%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Laboratory equipment </font></p>
</td>
<td valign="bottom" style="width:03.10%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:13.68%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>12,217
</td>
<td valign="bottom" style="width:03.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.34%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:13.68%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>12,217
</td>
<td valign="bottom" style="width:01.24%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:62.48%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Leasehold improvements </font></p>
</td>
<td valign="bottom" style="width:03.10%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,988
</td>
<td valign="bottom" style="width:03.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,988
</td>
<td valign="bottom" style="width:01.24%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:62.48%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Computers and software </font></p>
</td>
<td valign="bottom" style="width:03.10%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3,126
</td>
<td valign="bottom" style="width:03.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3,126
</td>
<td valign="bottom" style="width:01.24%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:62.48%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Furniture and fixtures </font></p>
</td>
<td valign="bottom" style="width:03.10%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,176
</td>
<td valign="bottom" style="width:03.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,176
</td>
<td valign="bottom" style="width:01.24%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:62.48%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.10%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>21,507
</td>
<td valign="bottom" style="width:03.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>21,507
</td>
<td valign="bottom" style="width:01.24%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:62.48%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Less accumulated depreciation and amortization </font></p>
</td>
<td valign="bottom" style="width:03.10%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(20,652
</td>
<td valign="bottom" style="width:03.12%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td colspan="2" valign="bottom" style="width:15.04%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(20,483
</td>
<td valign="bottom" style="width:01.24%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:62.48%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.10%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.34%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:13.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>855
</td>
<td valign="bottom" style="width:03.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.34%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:13.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,024
</td>
<td valign="bottom" style="width:01.24%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
11000
10000
2490000
2301000
17583000
16182000
-637573000
-658280000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Revenue Recognition</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;font-style:italic;">Collaboration and License Agreements</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company’s principal source of revenue to date has been its former collaboration and license agreements, which included upfront license payments, development milestones, reimbursement of research and development costs, potential profit sharing payments, commercial and sales-based milestones and royalties. The accounting for collaboration and license agreements requires subjective analysis and requires management to make estimates and assumptions about whether deliverables within multiple-element arrangements are separable from the other aspects of the contractual arrangement into separate units of accounting and to determine the arrangement consideration to be allocated to each unit of accounting.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">For multiple-element arrangements entered into or materially modified after January 1, 2011, the Company follows the provisions of Financial Accounting Standards Board (FASB) Accounting Standards Update (ASU) No. 2009-13—</font><font style="display: inline;font-style:italic;"> Multiple-deliverable Revenue Arrangements</font><font style="display: inline;"> (ASU No. 2009-13). ASU No. 2009-13 amended certain provisions of Accounting Standards Codification (ASC) Topic 605—</font><font style="display: inline;font-style:italic;"> Revenue Recognition</font><font style="display: inline;">. This standard addresses the determination of the unit(s) of accounting for multiple-element arrangements and how an arrangement’s consideration should be allocated to each unit of accounting.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Pursuant to this standard, each required deliverable is evaluated to determine if it qualifies as a separate unit of accounting. For the Company this determination includes an assessment as to whether the deliverable has “stand-alone value” to the customer separate from the undelivered elements. The arrangement’s consideration is then allocated to each separate unit of accounting based on the relative selling price of each deliverable. The estimated selling price of each deliverable is determined using the following hierarchy of values: (i) vendor-specific objective evidence of fair value, (ii) third-party evidence of selling price, or (iii) the Company’s best estimate of the selling price (BESP). The BESP reflects the Company’s best estimate of what the selling price would be if the deliverable was regularly sold by it on a stand-alone basis. The Company expects, in general, to use BESP for allocating consideration to each deliverable in future collaboration agreements. In general, the consideration allocated to each unit of accounting is then recognized as the related goods or services are delivered limited to the consideration not contingent upon future deliverables. The Company did not recognize any revenue related to collaboration and license agreements during the three months ended March 31, 2015 and 2014.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company accounts for development milestones under collaboration and license agreements pursuant to ASU No. 2010-17</font><font style="display: inline;font-style:italic;">Milestone Method of Revenue Recognition</font><font style="display: inline;"> (ASU No. 2010-17). ASU No. 2010-17 codified a method of revenue recognition that has been common practice. Under this method, contingent consideration from research and development activities that is earned upon the achievement of a substantive milestone is recognized in its entirety in the period in which the milestone is achieved. At the inception of each arrangement that includes milestone payments, the Company evaluates whether each milestone is substantive. This evaluation includes an assessment of whether (a) the consideration is commensurate with either (1) the entity’s performance to achieve the milestone, or (2) the enhancement of the value of the delivered item(s) as a result of a specific outcome resulting from the entity’s performance to achieve the milestone, (b) the consideration relates solely to past performance and (c) the consideration is reasonable relative to all of the deliverables and payment terms within the arrangement. The Company evaluates factors such as the scientific, clinical, regulatory, commercial and other risks that must be overcome to achieve the respective milestone, the level of effort and investment required and whether the milestone consideration is reasonable relative to all deliverables and payment terms in the arrangement in making this assessment. The Company does not have any ongoing collaboration and license agreements under which milestones may be achieved.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Royalty revenues are based upon a percentage of net sales. Royalties from the sales of products will be recorded on the accrual basis when results are reliably measurable, collectability is reasonably assured and all other revenue recognition criteria are met. Commercial and sales-based milestones, which are based upon the achievement of certain agreed-upon sales thresholds, will be recognized in the period in which the respective sales threshold is achieved and collectability is reasonably assured. The Company does not have any ongoing collaboration and license agreements under which royalties or commercial and sales-based milestones may be achieved.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="3" valign="bottom" style="width:30.58%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">March 31,</font></p>
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.86%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2014</font></p>
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Common stock options</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>10,123,204
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.86%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>8,179,958
</td>
<td valign="bottom" style="width:01.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Unvested restricted common stock</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>734,758
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.86%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>35,000
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="11" valign="bottom" style="width:47.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">March 31, 2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Cost</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Unrealized</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">gains</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Unrealized</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">losses</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Fair</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">value</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Cash and cash equivalents:</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Cash and money market funds (Level 1) </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>21,720
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>21,720
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Corporate debt securities due within 3 months of date of purchase (Level 2) </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11,535
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11,535
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total cash and cash equivalents </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>33,255
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>33,255
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Marketable securities:</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Corporate debt securities due within 1 year of date of purchase (Level 2) </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>43,345
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(5
</td>
<td valign="bottom" style="width:02.50%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>43,351
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total cash, cash equivalents and marketable securities </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>76,600
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(5
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>76,606
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="11" valign="bottom" style="width:47.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">December 31, 2014</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Cost</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Unrealized</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">gains</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Unrealized</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">losses</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Fair</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">value</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Cash and cash equivalents:</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Cash and money market funds (Level 1) </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>45,004
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>45,004
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Corporate debt securities due within 3 months of date of purchase (Level 2) </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,020
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,020
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total cash and cash equivalents </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>46,024
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>46,024
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Marketable securities:</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Corporate debt securities due within 1 year of date of purchase (Level 2) </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>51,662
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>12
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(8
</td>
<td valign="bottom" style="width:02.50%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td colspan="2" valign="bottom" style="width:10.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>51,666
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total cash, cash equivalents and marketable securities </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>97,686
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>12
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(8
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:08.70%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>97,690
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:56pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Future principal payments under the GECC and Oxford Term Loans as of March 31, 2015 were approximately as follows (in thousands):</font>
</p>
<p style="margin:0pt;text-indent:30.8pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="top" style="width:82.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Years ending December 31,</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:82.14%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">2015 </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6,913
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:82.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">2016 </font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,607
</td>
<td valign="bottom" style="width:01.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:82.14%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total principal payments </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11,520
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:82.14%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Less current portion </font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(9,221
</td>
<td valign="bottom" style="width:01.14%;background-color: #CCEEFF;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:82.14%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Long term portion </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,299
</td>
<td valign="bottom" style="width:01.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:60.08%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Shares</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Weighted</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">average</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">grant date</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">fair value</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">per share</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:60.08%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Outstanding at January 1, 2015</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>744,514
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.38%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3.65
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:60.08%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Vested</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(9,756
</td>
<td valign="bottom" style="width:02.78%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4.10
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:60.08%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Granted</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:60.08%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Forfeited</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:60.08%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Outstanding at March 31, 2015</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>734,758
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.38%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3.65
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:60.06%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Shares</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Weighted average</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">exercise price</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">per share</font></p>
</td>
<td valign="bottom" style="width:01.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Outstanding at January 1, 2015</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>8,829,343
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.38%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6.17
</td>
<td valign="bottom" style="width:01.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Options granted</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,693,686
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2.39
</td>
<td valign="bottom" style="width:01.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Options exercised</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:01.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Options cancelled</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>(399,825
</td>
<td valign="bottom" style="width:02.78%;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">)</font></p>
</td>
<td colspan="2" valign="bottom" style="width:16.70%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>9.14
</td>
<td valign="bottom" style="width:01.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Outstanding at March 31, 2015</font></p>
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>10,123,204
</td>
<td valign="bottom" style="width:02.78%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.38%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5.42
</td>
<td valign="bottom" style="width:01.02%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:60.06%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Exercisable at March 31, 2015</font></p>
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.68%;border-top:2pt double #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5,305,790
</td>
<td valign="bottom" style="width:02.78%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:2pt double #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:15.38%;border-top:2pt double #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6.45
</td>
<td valign="bottom" style="width:01.02%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:58.90%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="3" valign="bottom" style="width:35.48%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Three Months</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:02.44%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:58.90%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.14%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.16%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">2014</font></p>
</td>
<td valign="bottom" style="width:02.44%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:58.90%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Risk-free interest rate </font></p>
</td>
<td valign="bottom" style="width:03.18%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.14%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1.77
</td>
<td valign="bottom" style="width:03.18%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">%</font></p>
</td>
<td valign="bottom" style="width:16.16%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1.84
</td>
<td valign="bottom" style="width:02.44%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">%</font></p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:58.90%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Expected life in years </font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.14%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6.25
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.16%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6.25
</td>
<td valign="bottom" style="width:02.44%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:58.90%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Volatility </font></p>
</td>
<td valign="bottom" style="width:03.18%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.14%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>101
</td>
<td valign="bottom" style="width:03.18%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">%</font></p>
</td>
<td valign="bottom" style="width:16.16%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>104
</td>
<td valign="bottom" style="width:02.44%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">%</font></p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:58.90%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Expected dividend yield </font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.14%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:03.18%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:16.16%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">—</font></p>
</td>
<td valign="bottom" style="width:02.44%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:30pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Unrecognized stock-based compensation expense as of March 31, 2015 was as follows (dollars in thousands):</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Unrecognized</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">stock</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">compensation</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">expense</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 8pt">
<font style="display: inline;font-weight:bold;font-size:8pt;">Weighted</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">average</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">remaining</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">period</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;"></font><font style="display: inline;font-weight:bold;font-size:8pt;">(in years)</font></p>
</td>
<td valign="bottom" style="width:01.16%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Employee stock options</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>13,821
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2.79
</td>
<td valign="bottom" style="width:01.16%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Restricted stock</font></p>
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td colspan="2" valign="bottom" style="width:13.84%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,343
</td>
<td valign="bottom" style="width:02.88%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3.19
</td>
<td valign="bottom" style="width:01.16%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:65.40%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20pt;line-height:106.67%;text-indent: -10pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Total</font></p>
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:01.30%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.54%;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>16,164
</td>
<td valign="bottom" style="width:02.88%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
<td valign="bottom" style="width:13.84%;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2.85
</td>
<td valign="bottom" style="width:01.16%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman;font-size: 10pt">
</p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p><font size="1"> </font></p>
</div> </div>
22500000
11520000
9214000
9221000
4607000
2299000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Segment Reporting</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Operating segments are determined based on the way management organizes its business for making operating decisions and assessing performance. The Company has a single operating segment, which is the discovery, development and commercialization of drug products.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
2586000
1710000
P4Y
744514
734758
3.65
3.65
9756
100000
100000
4.10
P10Y
P6Y3M
P6Y3M
1.04
1.01
0.0184
0.0177
10300000
11600000
1261136
5305790
6.45
399825
1693686
5.02
1.92
8829343
10123204
6.17
5.42
9.14
2.39
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Stock-Based Compensation</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company recognizes stock-based compensation expense based on the grant date fair value of stock options granted to employees, officers and directors. The Company uses the Black-Scholes option pricing model to determine the grant date fair value as management believes it is the most appropriate valuation method for its option grants. The Black-Scholes model requires inputs for risk-free interest rate, dividend yield, volatility and expected lives of the options. Expected volatility is based upon the weighted average historical volatility data of the Company’s common stock. The risk-free rate for periods within the expected life of the option is based on the U.S. Treasury yield curve in effect at the time of the grant. The expected lives for options granted represent the period of time that options granted are expected to be outstanding. The Company uses the simplified method for determining the expected lives of options. The Company estimates the forfeiture rate based on historical data. This analysis is re-evaluated at least annually and the forfeiture rate is adjusted as necessary.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">For awards with graded vesting, the Company recognizes compensation costs based on the grant date fair value of awards on a straight-line basis over the requisite service period, which is generally the vesting period.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Certain of the employee stock options granted by the Company are structured to qualify as incentive stock options (ISOs). Under current tax regulations, the Company does not receive a tax deduction for the issuance, exercise or disposition of ISOs if the employee meets certain holding requirements. If the employee does not meet the holding requirements, a disqualifying disposition occurs, at which time the Company may receive a tax deduction. The Company does not record tax benefits related to ISOs unless and until a disqualifying disposition is reported. In the event of a disqualifying disposition, the entire tax benefit is recorded as a reduction of income tax expense. The Company has not recognized any income tax benefit for its share-based compensation arrangements due to the fact that the Company does not believe it is more likely than not it will realize the related deferred tax assets.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
1.75
65136000
46140000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">(5) Stockholders’ Equity</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Common Stock</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:25pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">Each common stockholder is entitled to one vote for each common share of stock held. The common stock will vote together with all other classes and series of stock of the Company as a single class on all actions to be taken by the Company’s stockholders. Each share of common stock is entitled to receive dividends, as and when declared by the Company’s board of directors.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:26pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The Company has never declared cash dividends on its common stock and does not expect to do so in the foreseeable future.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;font-style:italic;">At-The-Market Issuance Sales Agreement</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;text-indent:29.7pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In July 2014, the Company entered into an at-the-market issuance sales agreement (July 2014 Sales Agreement) with MLV & Co. LLC (MLV), pursuant to which the Company may issue and sell shares of its common stock from time to time, at the Company’s option, through MLV as its sales agent. Sales of common stock through MLV may be made by any method that is deemed an “at-the-market” offering as defined in Rule 415 promulgated under the Securities Act of 1933, as amended, including by means of ordinary brokers’ transactions at market prices, in block transactions or as otherwise agreed by the Company and MLV. Subject to the terms and conditions of the Sales Agreement, MLV will use commercially reasonable efforts to sell the common stock based upon the Company’s instructions (including any price, time or size limits or other customary parameters or conditions the Company may impose). The Company is not obligated to make any sales of its common stock under the Sales Agreement. Any shares sold will be sold pursuant to an effective shelf registration statement on Form S-3. The Company will pay MLV a commission of up to 3% of the gross proceeds. The July 2014 Sales Agreement may be terminated by the Company at any time.</font>
</p>
<p style="margin:0pt;text-indent:29.7pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In July 2014, the Company reserved up to $50 million under its shelf registration statement for issuance under the July 2014 Sales Agreement. In the third quarter of 2014, the Company sold an aggregate of 5,679,685 shares of common stock pursuant to the July 2014 Sales Agreement for an aggregate of approximately $23.0 million in gross proceeds at an average selling price of $4.05 per share. Net proceeds to the Company were approximately $22.5 million after deducting commissions and other transaction costs. As of March 31, 2015, approximately $27.0 million remained reserved under the Company’s shelf registration statement and the applicable prospectus supplement for possible future issuance under the July 2014 Sales Agreement.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
5679685
25300000
7257142
3300000
23000000
44300000
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">(10) Subsequent Events</font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;font-style:italic;">Public Offering</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">In April 2015, the Company raised approximately $44.3 million in gross proceeds from the sale of an aggregate 25,300,000 shares of its common stock in a public offering at a public offering price of $1.75 per share, including 3,300,000 shares upon the full exercise of the underwriters’ option to purchase additional shares. Certain of the Company’s directors and their affiliates, including its largest stockholder, purchased an aggregate of 7,257,142 shares in this offering at the public offering price. The net offering proceeds to the Company were approximately $41.8 million after deducting underwriters’ discounts, fees and commissions, and other offering expenses payable by the Company.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
<div> <div style="margin-left:0pt;margin-right:0pt;">
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;font-weight:bold;">Use of Estimates</font>
</p>
<p style="margin:0pt 0pt 0pt 11pt;text-indent: -11pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman;font-size: 10pt">
<font style="display: inline;">The preparation of financial statements in conformity with U.S. generally accepted accounting principles (GAAP) requires management to make estimates and assumptions that affect certain reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting periods. Significant items subject to such estimates and assumptions include contract research accruals, recoverability of long-lived assets, measurement of stock-based compensation, and the periods of performance under collaborative research and development agreements. The Company bases its estimates on historical experience and various other assumptions that management believes to be reasonable under the circumstances. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates.</font>
</p>
<p><font size="1"> </font></p>
</div> </div>
85438127
108376264