0010 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 0015 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 0020 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 0030 - Statement - Consolidated Statements of Stockholders' Equity and Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 0040 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 1010 - Disclosure - Nature of Business link:presentationLink link:calculationLink link:definitionLink 1020 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 1030 - Disclosure - Cash, Cash Equivalents and Marketable Securities link:presentationLink link:calculationLink link:definitionLink 1040 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 1050 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 1060 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 1070 - Disclosure - Other Accrued Liabilities link:presentationLink link:calculationLink link:definitionLink 1080 - Disclosure - License and Development Agreements link:presentationLink link:calculationLink link:definitionLink 8020 - Disclosure - Term Loans link:presentationLink link:calculationLink link:definitionLink 1090 - Disclosure - Restructuring link:presentationLink link:calculationLink link:definitionLink 1100 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 1110 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 1120 - Disclosure - Related Party Transactions link:presentationLink link:calculationLink link:definitionLink 1130 - Disclosure - Retirement Plan link:presentationLink link:calculationLink link:definitionLink 1140 - Disclosure - Quarterly Financial Data (unaudited) link:presentationLink link:calculationLink link:definitionLink 8000 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 8010 - Disclosure - Collaborative Development, Commercialization and License Agreement with GSK link:presentationLink link:calculationLink link:definitionLink 1150 - Disclosure - Subsequent Event-Public Offering link:presentationLink link:calculationLink link:definitionLink 0000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 0031 - Statement - Consolidated Statements of Stockholders' Equity and Comprehensive Income (Loss) (Calc 2) link:presentationLink link:calculationLink link:definitionLink