New at the Market Issuance Sales Agreement [Member]
New At-The-Market Issuance Sales Agreement
Represents information pertaining to new at-the-market issuance sales agreement for the sale of the entity's common shares.
License Arrangement [Member]
License Arrangement
Represents information pertaining to license arrangement.
Number of Lead Candidates
Number of lead candidates
Represents the number of lead candidates.
Number of Lead Candidates To Be Developed
Number of lead candidates to be developed
Represents the number of lead candidates to be developed.
Directors and their affiliates, including its largest stockholder
Largest Shareholder Members Of Board Of Directors And Entities Affiliated With Directors [Member]
Represents the information pertaining to directors and entities affiliated with the directors including the largest shareholder of the entity.
Reserves for Uncertain Tax Positions
Reserves for uncertain tax positions
Represents the amount pertaining to reserves for uncertain tax positions.
Patents [Policy Text Block]
Patents
Disclosure of accounting policy for patents.
Patents [Abstract]
Patents
Patent Expenses
Patent expenses
Represents the expenses incurred to secure and defend patents during the period.
Income Tax Reconciliation State and Local Operating Loss Expiration Amount
State net operating loss expiration
The portion of the difference, between total income tax expense or benefit as reported in the income statement for the year/accounting period and the expected income tax expense or benefit computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations that is attributable to state and local net operating loss expiration.
Amendment Description
Operating Loss Carryforwards Expiration Amount
Net operating loss carryforwards expired
Represents the amount of the operating loss carryforwards, before tax effects, that expired during the period.
Amendment Flag
M L V and Co LLC [Member]
MLV & Co. LLC
Represents details pertaining to MLV and Co. LLC, with whom the entity entered into an at-the-market sales agreement.
Computers and Software [Member]
Computers and software
Long-lived, depreciable assets that are used in the creation, maintenance and utilization of information systems and purchased software applications.
Debt securities due within three months of date of purchase issued by domestic or foreign corporate business, banks and other entities with a promise of repayment.
Corporate Debt Securities Due within Three Months [Member]
Corporate debt securities due within 3 months of date of purchase
Represents the 2006 Stock Plan of the entity.
Stock Plan 2006 [Member]
2006 Stock Plan
Hoffman La Roche [Member]
Roche
Represents information pertaining to Hoffman-La Roche.
Represents the General Electric Capital Corporation Term Loan in which General Electric Capital Corporation is the lender of the debt.
General Electric Capital Corporation Term Loan [Member]
GECC Term Loan
Oxford Finance Corporation Term Loan [Member]
Oxford Term Loan
Represents the Oxford Finance Corporation Term Loan in which Oxford Finance Corporation is the lender of the debt.
Cash and Money Market Funds [Member]
Cash and money market funds
Currency on hand as well as demand deposits with banks or financial institutions. It includes other kinds of accounts that have the general characteristics of demand deposits and a fund that invests in short-term money-market instruments, for example, but not limited to, commercial paper, bankers acceptances, repurchase agreements, government securities, certificates of deposit and other highly liquid securities.
Document and Entity Information
The carrying value as of the balance sheet date of obligations incurred and payable relating to service fees paid to contract manufacturers in connection with the production of clinical drug supplies and to contract research organizations in connection with preclinical studies and clinical trials. Used to reflect the current portion of liabilities (due within one year or within the normal operating cycle if longer).
Accrued Contract Research Costs
Accrued contract research costs
Other accrued liabilities
Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Excludes accrued contract research costs. (Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Other accrued liabilities
Accrued Liabilities Current Excluding Accrued Contract Research Costs
Collaboration Revenues [Abstract]
Collaboration revenues:
Revenues:
License and Milestone Revenues
License and milestone revenue
Revenues earned by the entity under collaborative research and development agreements for nonrefundable, up-front license fees and milestone payments, excluding cost sharing reimbursements of research and development costs.
License and milestone revenue recognized
Collaborative Revenues
The aggregate revenue earned under collaborative research and development agreements.
Total collaboration revenues
Collaboration revenues
Cost Sharing Reimbursements
Cost sharing reimbursements, net
Cost sharing revenue, consisting of reimbursements earned by the entity for costs incurred under collaborative research and development agreements, net of any reimbursements by the entity for agreed-upon costs incurred by partners.
Cost sharing revenue recognized
Total revenues
Total Revenues
Total aggregate revenue earned under collaborative research and development agreements and grants.
Current Fiscal Year End Date
Award Type [Axis]
Increase (Decrease) Accrued Contract and Research Costs
Accrued contract research costs
The increase (decrease) during the reporting period in accrued contract research costs.
Proceeds from the sale of common stock to related parties
Proceeds from Issuance of Common Stock to Related Parties
Represents the proceeds from the issuance of common stock to related parties.
The disclosure for accrued liabilities at the end of the reporting period, excluding accrued contract research costs.
Other Accrued Liabilities Disclosure [Text Block]
Other Accrued Liabilities
License and Development Agreements
Schedule of Share Based Compensation Expense Allocation of Compensation Costs and Recognized Period Costs [Table Text Block]
Schedule of stock-based compensation expense
Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the income statement for the period. This may include the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits. It includes the reporting line for the costs expensed.
Schedule of Other Accrued Liabilities [Table Text Block]
Schedule of other accrued liabilities
Tabular disclosure of the components of other accrued liabilities which excludes accrued contract research costs.
Grant Revenue [Abstract]
Grant Revenue
Amount of Grant Awarded
Amount of grant awarded
The amount of grants awarded from a governmental agency.
Represents the maturity period from date of purchase to classify an investment as cash and cash equivalents.
Maturity period from date of purchase to classify an investment as cash and cash equivalents
Maturity Period from Date of Purchase to Classify Investment as Cash and Cash Equivalents
Maturity Period from Date of Purchase to Classify Investment as Marketable Securities
Represents the maturity period from date of purchase to classify an investment as marketable securities.
Maturity period from date of purchase to classify an investment as marketable securities
Cash and Cash Equivalents and Available for Sale Securities, Gross Unrealized Gains
Cash, cash equivalents and marketable securities, unrealized gains
This item represents the gross unrealized gains for cash and cash equivalents securities, at a point in time, which are categorized neither as held-to-maturity nor trading securities.
Document Period End Date
Cash and Cash Equivalents and Available for Sale Securities, Gross Unrealized Losses
Cash, cash equivalents and marketable securities, unrealized losses
This item represents the gross unrealized losses for cash and cash equivalents securities, at a point in time, which are categorized neither as held-to-maturity nor trading securities.
Proceeds from Issuance or Sale of Equity, Gross
Gross proceeds from the sale of common stock
Represents the cash inflow from the sale of common stock before deducting underwriters' discounts, fees and commissions, and other offering expenses.
Common Stock Aggregate Offering Price
Maximum aggregate offering price
Represents the maximum aggregate offering price the entity may issue and sell shares of its common stock from time to time, at the entity's option, according to at-the-market issuance sales agreement with third party.
Percentage of gross proceeds payable as commission
Represents the percentage of gross proceeds payable as commission during the period.
Percentage of Gross Proceeds Payable as Commission
Increase in number of shares reserved for issuance
Represents the increase in the maximum number of shares (or other type of equity) that was initially approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan.
Share Based Compensation Arrangement by Share Based Payment Award, Increase in Number of Shares Reserved for Issuance
Share Based Compensation Arrangement by Share Based Payment Award, Percentage on Outstanding Common Stock for Computation of Annual Increase in Number of Shares Reserved for Issuance
Percentage of outstanding shares of common stock used to compute annual increase in number of shares reserved for issuance
Represents the percentage of outstanding shares of common stock used to compute the annual increase in the number of shares reserved for issuance.
Share Based Compensation Arrangement by Share Based Payment Award, Options Outstanding Weighted Average Exercise Price [Abstract]
Weighted average exercise price
Share Based Compensation Arrangement by Share Based Payment Award, Options Outstanding Weighted Average Remaining Contractual Life [Abstract]
Weighted average remaining contractual life
Share Based Compensation Arrangement by Share Based Payment Award, Options Outstanding Aggregate Intrinsic Value [Abstract]
Aggregate intrinsic value
Represents the non-refundable upfront license payment received.
Collaborative Arrangement, Upfront License Fee Received
Non-refundable upfront license payment received
Represents the initial term for research under collaborative arrangements.
Collaborative Arrangement, Initial Term for Research
Initial term for research
Amount received related to research and development support
Represents the amount received in research and development support.
Collaborative Arrangement, Research and Development Support Received
Arrangements and Non-arrangement Transactions [Domain]
Collaborative Arrangement, Non Refundable Upfront License Fee Accelerated Recognition
Accelerated recognition of remaining deferred revenue from upfront payment
Represents the accelerated recognition of remaining deferred revenue from upfront payment during the period under the collaborative agreement.
Collaborative Arrangement, License Revenue Recognized
License revenue recognized
Represents the license revenue recognized during the period under the collaborative agreement.
Number of equal monthly payments of principal plus accrued interest
Represents the number of equal monthly payments of principal plus accrued interest made by the entity.
Debt Instrument, Number of Equal Monthly Payments of Principal Plus Accrued Interest
Represents the number of equal monthly payments of principal plus accrued interest for additional borrowings that the entity may draw down in equipment financing under the loan modification agreement.
Debt Instrument, Number of Equal Monthly Payments of Principal Plus Accrued Interest for Additional Borrowings Available
Number of equal monthly payments of principal plus accrued interest
Exit fee to be paid
Represents the obligation to pay exit fee at the time of final payment of the outstanding principal balance.
Debt Instrument, Exit Fee Payable at End of Term
Debt Instrument, Covenant Equipment Financing Allowed without any Restriction
Amount of equipment financing allowed under covenants without any restriction
Represents the amount of equipment financing allowed without any restrictive covenants.
Debt Instrument, Covenant Debt Assumption from Acquisitions Requiring Prior Written Consent
Amount of debt assumption from acquisitions requiring prior written consent under covenants
Represents the amount of debt assumption from acquisitions requiring prior written consent.
Stock Issued During Period, Value, Related Party
Issuance of common shares to related parties
Equity impact of the value of stock issued during the period to related party by the reporting entity.
Proceeds from the sale of common stock to related parties
Number of shares issued to related party during the reporting period.
Shares sold to related party
Stock Issued During Period, Shares, Related Party
Issuance of common shares to related parties (in shares)
Interest Expense Recognized for Debt Financing Costs
Transaction and exit fees and expenses recognized in interest expense
Amount of expense included in interest expense to issue debt and obtain financing associated with the related debt instruments.
Defined Contribution Plan Employers Matching Contribution Vesting Period
Vesting schedule of employer's matching contribution
Represents the vesting period of employer's matching contribution under the 401 (k) plan.
Common Stock Voting Rights Number
Number of votes per share that common stockholders are entitled to receive
Represents the number of votes per share that common stockholders are entitled to receive.
Issuer-Directed Registered Direct Offering
Represents information pertaining to the issuer-directed registered direct offering of the common shares of the entity.
Issuer Directed Registered Direct Offering [Member]
Issuer-Directed Registered Direct Offering
Registered Direct Offering [Member]
Registered Direct Offering
Represents information pertaining to the registered direct offering of the common shares of the entity.
At the Market Issuance Sales Agreement [Member]
Represents information pertaining to at-the-market issuance sales agreement for the sale of the entity's common shares.
At-The-Market Issuance Sales Agreement
Directors Including Largest Shareholder [Member]
Directors, including the largest stockholder
Represents information pertaining to directors including the largest shareholder of the entity.
Public Offering [Member]
Public Offering
Represents a public offering of the entity's common shares.
Public Offering Initial Closing [Member]
Represents the initial closing of a public offering of the entity's common shares.
Public offering, initial closing
Public Offering Second Closing [Member]
Represents the second closing, underwriters' option to purchase additional shares, of a public offering of the entity's common shares.
Public offering, second closing, underwriters' option to purchase additional shares
Directors and Entities Affiliated with Directors [Member]
Directors and entities affiliated with the directors
Represents information pertaining to directors and entities affiliated with the directors of the entity.
Founder and Member of Board of Directors [Member]
Founder and a member of the board of directors
Represents information pertaining to its founder and a member of the board of directors of the entity.
Stock Issued During Period Value New Issues Excluding Sales to Related Parties
Issuance of common shares in equity offering, excluding to related parties, net
Equity impact of the value of new stock issued during the period, excluding stock issued to related parties.
Stock Issued During Period Shares New Issues Excluding Sales to Related Parties
Number of new shares issued during the period, excluding sales to related parties.
Issuance of common shares in equity offering, net (in shares)
Offerings of Entity Stock [Table]
Summarization of information disclosed concerning offerings of the entity's shares.
Largest Shareholder and Member of Board of Directors [Member]
Person serving on the board of directors who is the largest shareholder in the entity.
Director who is largest shareholder
Debt Instrument, Additional Borrowings Available
Additional amount that the Company may fully utilized in equipment financing
Represents the additional amount of borrowings that the entity may draw down in equipment financing under the loan modification agreement.
Represents the deductions related to the exercise of common stock options included in net operating loss carryforwards.
Deductions Related to Exercise of Common Stock Options Included in Net Operating Loss Carryforwards
Deductions related to the exercise of common stock options included in net operating loss carryforwards
Number of Non Cancelable and Renewable Operating Leases
Represents the number of non-cancelable and renewable operating leases.
Number of non-cancelable and renewable operating leases
Stock Issued During Period Warrants Issues
Warrants issued (in shares)
Number of warrants issued during the period.
Marketable securities, Unrealized gains
Amount before tax of unrealized gain in accumulated other comprehensive income (AOCI) on investments in debt and equity securities classified as available-for-sale.
Available for Sale Securities Accumulated Gross Unrealized Gain Before Tax
Available for Sale Securities Accumulated Gross Unrealized Gain Before Tax
Marketable securities, Unrealized losses
Available for Sale Securities Accumulated Gross Unrealized Loss Before Tax
Amount before tax of unrealized loss in accumulated other comprehensive income (AOCI) on investments in debt and equity securities classified as available-for-sale.
Available for Sale Securities Accumulated Gross Unrealized Loss Before Tax
Employee stock options
An arrangement whereby an employee or member of the Board of Directors is entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement.
Employee and Directors Stock Options [Member]
Common stock options
Stock option
Co-Development Agreement
Entity Well-known Seasoned Issuer
Entity Voluntary Filers
Entity Current Reporting Status
Entity Filer Category
Entity Public Float
Entity Registrant Name
Entity Central Index Key
Entity Common Stock, Shares Outstanding
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Type
Summary of Significant Accounting Policies
Accounts payable
Accounts Payable, Current
Professional fees
Accrued Professional Fees, Current
Less accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated other comprehensive income
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive income (loss)
Accumulated Other Comprehensive Income (Loss) [Member]
Additional paid-in-capital
Additional Paid in Capital, Common Stock
Additional paid-in Capital
Additional Paid-in Capital [Member]
Compensation expense related to stock options for services
Adjustments to Additional Paid in Capital, Share-based Compensation, Stock Options, Requisite Service Period Recognition
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Stock-based compensation expense
Allocated Share-based Compensation Expense
Antidilutive Securities [Axis]
Anti-dilutive securities
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities, Name [Domain]
Outstanding securities not included in the computation of diluted net income (loss) per common share as their inclusion would be anti-dilutive (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Impairment of Long-Lived Assets
Asset Impairment Charges [Abstract]
Total assets
Assets
Current assets:
Assets, Current [Abstract]
Assets
Assets [Abstract]
Total current assets
Assets, Current
Equipment under capital lease
Assets Held under Capital Leases [Member]
Marketable securities
Available-for-sale Securities
Marketable securities
Available-for-sale Securities, Current
Counterparty Name [Axis]
2015
Capital Leases, Future Minimum Payments Due in Two Years
Total minimum payments
Capital Leases, Future Minimum Payments Due
Less: amount representing interest
Capital Leases, Future Minimum Payments, Interest Included in Payments
Current portion of capital lease obligations
Less current portions of obligations
Capital Lease Obligations, Current
Present value of minimum payments
Capital Lease Obligations
Capital lease obligations, net of current portion
Long term obligation
Capital Lease Obligations, Noncurrent
2016
Capital Leases, Future Minimum Payments Due in Three Years
Capital leases
Capital Leases, Future Minimum Payments, Present Value of Net Minimum Payments, Fiscal Year Maturity [Abstract]
Assets acquired under capital lease
Capital Lease Obligations Incurred
2014
Capital Leases, Future Minimum Payments Due, Next Twelve Months
Cost
Reported Value Measurement [Member]
Cash and Cash Equivalents [Axis]
Cash and cash equivalents
Cash and cash equivalents at beginning of period
Cash and cash equivalents at end of period
Cash and Cash Equivalents, at Carrying Value
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash, Cash Equivalents and Marketable Securities
Cash, Cash Equivalents, and Marketable Securities [Text Block]
Cash and cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Cash, Cash Equivalents and Marketable Securities
Total cash, cash equivalents and marketable securities
Cash, cash equivalents and marketable securities
Cash, Cash Equivalents, and Short-term Investments
At-The-Market Issuance Sales Agreement
License and Development Agreements
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative agreement
Collaborative Arrangement [Member]
Co-Development Agreement
Collaborative Arrangement Disclosure [Text Block]
Commitments and Contingencies.
Commitments and contingencies (Note 11)
Commitments and Contingencies
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Common stock
Common Stock [Member]
Common stock, par value $0.0001 per share Authorized: 200,000,000 shares at March 31, 2014 and December 31, 2013; 87,593,991 and 85,232,506 shares issued and outstanding at March 31, 2014 and December 31, 2013, respectively
Common Stock, Value, Issued
Common stock, shares issued
Balance (in shares)
Balance (in shares)
Common Stock, Shares, Issued
Common stock, Authorized shares
Common Stock, Shares Authorized
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Common Stock
Common Stock, Number of Shares, Par Value and Other Disclosures [Abstract]
Retirement Plan
Significant portions of deferred tax assets and deferred tax liabilities
Components of Deferred Tax Assets and Liabilities [Abstract]
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Schedule of future minimum payments, excluding operating costs and taxes, under the Company's capital and non-cancellable operating leases
Contractual Obligation, Fiscal Year Maturity Schedule [Table Text Block]
Corporate debt securities due within 1 year of date of purchase
Corporate Debt Securities [Member]
Operating expenses:
Costs and Expenses [Abstract]
Term Loans
Commitments and Contingencies
Debt Instrument [Line Items]
Schedule of Long-term Debt Instruments [Table]
Term Loans
Term Loans
Debt Disclosure [Text Block]
Legal fees and expenses paid
Debt Issuance Cost
Annual interest rate on term loan (as a percent)
Debt Instrument, Interest Rate, Stated Percentage
Depreciation and amortization
Deferred Tax Assets, Property, Plant and Equipment
Deferred tax assets:
Deferred Tax Assets, Net of Valuation Allowance [Abstract]
Deferred tax assets
Deferred Tax Assets, Gross
Other
Deferred Tax Assets, Other
Federal and state research and development credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Deferred compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Employee Compensation
Federal and state net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Less valuation allowance
Deferred Tax Assets, Valuation Allowance
Matching contribution percentage
Defined Benefit Plan Disclosure [Line Items]
Percentage of employee's salary that is subject to Company matching
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Company contributions
Defined Contribution Plan, Cost Recognized
Depreciation and amortization
Depreciation, Depletion and Amortization
Director
Director [Member]
Stock-Based Compensation
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
Stock-Based Compensation
Basic and diluted net loss per common share (in dollars per share)
Net loss per common share-basic and diluted (in dollars per share)
Earnings Per Share, Basic and Diluted
Basic and Diluted Loss Per Common Share
Earnings Per Share, Policy [Policy Text Block]
Net loss per common share:
Basic and Diluted Earnings (Loss) Per Common Share
Earnings Per Share [Abstract]
Compensation and benefits
Employee-related Liabilities, Current
Unrecognized stock compensation expense
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized
Weighted average remaining period
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
Total cash received from stock option exercises
Employee Service Share-based Compensation, Cash Received from Exercise of Stock Options
Laboratory equipment
Equipment [Member]
Equity Component [Domain]
Fair value
Estimate of Fair Value Measurement [Member]
Fair Value, Hierarchy [Axis]
Measurement Basis [Axis]
Fair Value Hierarchy [Domain]
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Fair Value Measurement [Domain]
Level 1
Fair Value, Inputs, Level 1 [Member]
Level 2
Fair Value, Inputs, Level 2 [Member]
Furniture and fixtures
Furniture and Fixtures [Member]
General and administrative
General and Administrative Expense
General and administrative
General and Administrative Expense [Member]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of assets
Impairment of Long-Lived Assets Held-for-use
Condensed Consolidated Statements of Operations
Income Statement Location [Axis]
Income Taxes
Income Tax Authority [Domain]
Income Tax Authority [Axis]
Income Taxes
Income Tax Disclosure [Text Block]
Income Statement Location [Domain]
Increase in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
State tax rate change
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount
Differences between the actual tax provision (benefit) and the tax provision (benefit) computed using the United States federal income tax rate
Effective Income Tax Rate Reconciliation, Amount [Abstract]
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Compensation Cost, Amount
Tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Amount
Income Taxes
Income Tax Uncertainties [Abstract]
Benefit at statutory rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Income Taxes
Income Tax, Policy [Policy Text Block]
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
Other
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Foreign rate differential
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Accounts payable
Increase (Decrease) in Accounts Payable, Trade
Other assets
Increase (Decrease) in Other Noncurrent Assets
Deferred collaboration revenue
Increase (Decrease) in Deferred Revenue
Other accrued liabilities
Increase (Decrease) in Other Accrued Liabilities
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Collaboration receivable
Increase (Decrease) in Receivables
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Stockholders' Equity
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Interest expense, net
Interest Income (Expense), Nonoperating, Net
Interest expense recognized
Interest Expense, Debt
Cash paid for interest
Interest Paid
Federal
Internal Revenue Service (IRS) [Member]
Long-term Debt, Type [Axis]
Long-term Debt, Type [Domain]
Leasehold improvements
Leasehold Improvements [Member]
Total current liabilities
Liabilities, Current
Total liabilities and stockholders' equity
Liabilities and Equity
Total long-term liabilities
Liabilities, Noncurrent
Current liabilities:
Liabilities, Current [Abstract]
Total liabilities
Liabilities
Long-term liabilities:
Liabilities, Noncurrent [Abstract]
Liabilities and Stockholders' Equity
Liabilities and Equity [Abstract]
2015
Long-term Debt, Maturities, Repayments of Principal in Year Two
2016
Long-term Debt, Maturities, Repayments of Principal in Year Three
2014
Long-term Debt, Maturities, Repayments of Principal in Next Twelve Months
Major Types of Debt and Equity Securities [Axis]
Major Types of Debt and Equity Securities [Domain]
Marketable Securities
Marketable Securities, Policy [Policy Text Block]
Future principal payments under the GECC and Oxford Term Loans
Maturities of Long-term Debt [Abstract]
Maximum
Maximum [Member]
Minimum
Minimum [Member]
Nature of Business
Nature of Operations [Text Block]
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract]
Cash flows from operating activities:
Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract]
Net increase (decrease) in cash and cash equivalents
Net Cash Provided by (Used in) Continuing Operations
Net loss
Net income (loss) for basic and diluted calculations
Net loss
Net loss
Net Income (Loss) Available to Common Stockholders, Basic
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities, Continuing Operations
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities, Continuing Operations
Net cash provided by (used in) investing activities
Net Cash Provided by (Used in) Investing Activities, Continuing Operations
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract]
Officer
Officer [Member]
Operating leases
Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract]
2017
Operating Leases, Future Minimum Payments, Due in Four Years
Total operating expenses
Operating Expenses
2016
Operating Leases, Future Minimum Payments, Due in Three Years
Rent expense under operating leases
Operating Leases, Rent Expense, Net
2014
Operating Leases, Future Minimum Payments Due, Next Twelve Months
Loss from operations
Loss from operations
Operating Income (Loss)
Operating Loss Carryforwards [Table]
Income Taxes
Operating Loss Carryforwards [Line Items]
2015
Operating Leases, Future Minimum Payments, Due in Two Years
Total minimum payments
Operating Leases, Future Minimum Payments Due
Net operating loss carryforwards
Operating Loss Carryforwards
Nature of Business
Summary of Significant Accounting Policies
Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block]
Other assets
Other Assets, Noncurrent
Other (expense) income:
Other
Other Accrued Liabilities, Current
Other comprehensive income:
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Unrealized (loss) gain on available-for-sale securities
Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent
Other Accrued Liabilities
Purchase and retirement of common stock from an officer
Payments for Repurchase of Common Stock
Purchases of marketable securities
Payments to Acquire Available-for-sale Securities
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Retirement Plan
Pension and Other Postretirement Benefits Disclosure [Text Block]
Plan Name [Domain]
Plan Name [Axis]
Preferred stock, par value (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value $0.0001 per share Authorized: 5,000,000 shares at March 31, 2014 and December 31, 2013; no shares issued and outstanding at March 31, 2014 and December 31, 2013
Preferred Stock, Value, Issued
Preferred stock, shares issued
Preferred Stock, Shares Issued
Preferred stock, Authorized shares
Preferred Stock, Shares Authorized
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Principal amount of debt issued
Proceeds from Issuance of Debt
Proceeds from Issuance or Sale of Equity
Net proceeds after deducting commissions and other transactions costs
Net proceeds after deducting offering expenses payable
Proceeds from term loans
Proceeds from Issuance of Secured Debt
Maturities of marketable securities
Proceeds from Maturities, Prepayments and Calls of Available-for-sale Securities
Proceeds from issuance of common stock, net of transaction costs, and exercise of common stock options
Proceeds from Issuance of Common Stock
Proceeds resulting from exercise of stock options
Proceeds from Stock Options Exercised
Estimated useful lives
Property, Plant and Equipment, Useful Life
Property and equipment, gross
Property, Plant and Equipment, Gross
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Property, Plant and Equipment, Net
Property and equipment, net
Property and equipment, net
Property and Equipment
Schedule of property and equipment
Property, Plant and Equipment [Table Text Block]
Property, Plant and Equipment, Type [Domain]
Property, Plant and Equipment, Type [Axis]
Property and Equipment
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment
Property, Plant and Equipment [Line Items]
Quarterly Financial Data (unaudited)
Quarterly Financial Information [Text Block]
Quarterly Financial Data (unaudited)
Range [Axis]
Range [Domain]
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Related Party Transaction [Line Items]
Related Party [Axis]
Consulting fees paid
Related Party Transaction, Expenses from Transactions with Related Party
Related Party [Domain]
Related Party Transactions
Payment of term loans
Repayments of Secured Debt
Payment of capital lease obligations
Repayment of remaining principal outstanding under existing equipment leases
Repayments of Long-term Capital Lease Obligations
Counterparty Name [Domain]
Research and development
Research and Development Expense [Member]
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Research and development credits
Research Tax Credit Carryforward [Member]
Research and development
Research and Development Expense (Excluding Acquired in Process Cost)
Unvested restricted common stock
Restricted stock awards
Restricted stock
Restricted Stock [Member]
Cash and Cash Equivalents [Domain]
Accumulated deficit
Retained Earnings [Member]
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Grant revenue
Revenue from Grants
Revenue Recognition
Revenue Recognition, Policy [Policy Text Block]
Collaboration Revenue
Revenues [Abstract]
Exercisable at the end of the period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Expected life in years
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Expiration period
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period
Exercisable at the end of the period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Outstanding at the end of the period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Revenues:
Revenue, Net [Abstract]
Schedule of unrecognized stock-based compensation expense
Schedule of Unrecognized Compensation Cost, Nonvested Awards [Table Text Block]
Summary of the outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Investments [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Summary of stock option activity
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
Schedule of weighted average assumptions used to estimate fair value of each employee stock option award
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of future principal payments under the GECC and Oxford Term Loans
Schedule of Maturities of Long-term Debt [Table Text Block]
Schedule of differences between the actual tax provision (benefit) and the tax provision (benefit) computed using the United States federal income tax rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of effects of temporary differences that give rise to significant portions of deferred tax assets and deferred tax liabilities
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Summary of unvested restricted share activity
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
Schedule of quarterly results of operations
Schedule of Quarterly Financial Information [Table Text Block]
Cash, Cash Equivalents and Marketable Securities
Schedule of Investments [Line Items]
Summary of cash, cash equivalents and available-for-sale marketable securities
Cash, Cash Equivalents and Investments [Table Text Block]
Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table]
Schedule of Defined Benefit Plans Disclosures [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Property, Plant and Equipment [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Term loans, net of current portion
Long term obligation
Secured Long-term Debt, Noncurrent
Current portion of term loans
Less current portion
Secured Debt, Current
Total principal payments
Present value of minimum payments
Principal balance
Secured Debt
Segment Reporting
Segment Reporting, Policy [Policy Text Block]
Weighted average grant date fair value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Additional Disclosures [Abstract]
Shares
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Options granted (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Options cancelled (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Outstanding at the end of the period (in shares)
Outstanding at the beginning of the period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Vested (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Share-based Compensation
Stock-based compensation expense
Vesting period
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Options granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Stock-Based Compensation
Stock-based compensation expense
Unrecognized stock-based compensation expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Outstanding at the beginning of the period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Outstanding at the end of the period (in dollars per share)
Forfeited (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Selling price per share (in dollars per share)
Closing stock price (in dollars per share)
Share Price
Options exercised (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Exercisable at the end of the period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Total fair value of restricted stock vested during the period
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Options cancelled (in shares)
Vested (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Exercisable at the end of the period (in shares)
Additional disclosures
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Shares available for future issuance
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Total intrinsic value of options exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Volatility (as a percent)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Shares reserved for issuance
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Risk-free interest rate (as a percent)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Weighted average assumptions used to estimate fair value of each employee stock option award
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Weighted-average grant date fair value of options (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Outstanding at the beginning of the period (in dollars per share)
Outstanding at the end of the period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Stock-Based Compensation
Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]
Outstanding at the beginning of the period (in shares)
Outstanding at the end of the period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Outstanding at the end of the period
Shares
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Equity Award [Domain]
State
State and Local Jurisdiction [Member]
Statement [Table]
Statement
Stockholders' Equity
Statement [Line Items]
Statement of Stockholders' Equity [Abstract]
Condensed Consolidated Statements of Cash Flows
Equity Components [Axis]
Condensed Consolidated Statements of Comprehensive Loss
Condensed Consolidated Balance Sheets
Purchase and retirement of common shares from an officer
Stock Repurchased and Retired During Period, Value
Exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Forfeitures of restricted common shares (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Forfeited
Issuance of restricted common shares (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Purchase and retirement of common shares from an officer (in shares)
Number of shares purchased and retired upon the vesting of restricted common stock in order to fund the related tax liability
Stock Repurchased and Retired During Period, Shares
Exercise of stock options (in shares)
Options exercised (in shares)
Aggregate number of shares of common stock options exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Number of shares sold by the entity
Stock Issued During Period, Shares, New Issues
Value of shares sold by the entity
Stock Issued During Period, Value, New Issues
Stockholders' equity:
Stockholders' Equity Attributable to Parent [Abstract]
Balance
Balance
Total stockholders' equity
Stockholders' Equity Attributable to Parent
Stockholders' Equity
Stockholders' Equity
Stockholders' Equity Note Disclosure [Text Block]
Subsequent Events
Subsequent Events [Text Block]
Subsequent Events
Subsequent Event [Table]
Subsequent Events
Subsequent Event [Line Items]
Subsequent event
Subsequent Event [Member]
Subsequent Event Type [Domain]
Subsequent Event Type [Axis]
Supplemental disclosure of cash flow information:
Supplemental Cash Flow Information [Abstract]
Research and development tax credit carryforwards
Tax Credit Carryforward, Amount
Tax Credit Carryforward, Name [Domain]
Income Taxes
Tax Credit Carryforward [Line Items]
Tax Credit Carryforward [Table]
Tax Credit Carryforward [Axis]
Type of Arrangement and Non-arrangement Transactions [Axis]
Uncertain tax items
Liability for uncertain tax positions
Unrecognized Tax Benefits
Amount of accrued interest or penalties related to uncertain tax positions
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Increase (decrease) in valuation allowance
Valuation Allowance, Deferred Tax Asset, Change in Amount
Effect of dilutive securities
Basic and diluted weighted average number of common shares outstanding (in shares)
Basic and diluted weighted average number of common shares outstanding
Shares used in computing net loss per common share-basic and diluted
Weighted Average Number of Shares Outstanding, Basic and Diluted
Weighted average selling price (in dollars per share)
Weighted Average Selling Price Per Share
Represents the weighted average selling price of a single share of a number of saleable stocks of a company.