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00200 - Statement - Consolidated Statements of Operations
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00300 - Statement - Consolidated Statements of Comprehensive Loss
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00500 - Statement - Consolidated Statements of Cash Flows
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40301 - Disclosure - Cash, Cash Equivalents and Marketable Securities (Details)
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40401 - Disclosure - Property and Equipment (Details)
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41101 - Disclosure - Income Taxes - Statutory Rate Reconciliation and Temporary Differences (Details)
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41201 - Disclosure - Commitments and Contingencies (Details)
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00090 - Document - Document and Entity Information
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00105 - Statement - Consolidated Balance Sheets (Parenthetical)
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00400 - Statement - Consolidated Statements of Stockholders' Equity
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10101 - Disclosure - Nature of Business
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10201 - Disclosure - Summary of Significant Accounting Policies
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10301 - Disclosure - Cash, Cash Equivalents and Marketable Securities
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10501 - Disclosure - Stockholders' Equity
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10601 - Disclosure - Stock-Based Compensation
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10701 - Disclosure - Other Accrued Liabilities
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10801 - Disclosure - Co-Development and License Agreements
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10901 - Disclosure - Term Loans
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11001 - Disclosure - Restructurings - November 2015 and February 2016
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11101 - Disclosure - Income Taxes
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11201 - Disclosure - Commitments and Contingencies
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11301 - Disclosure - Related Party Transactions
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11401 - Disclosure - Retirement Plan
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11501 - Disclosure - Quarterly Financial Data (unaudited)
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11601 - Disclosure - Subsequent Event-Elesclomol (Mitochondria-Targeting Agent)
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20202 - Disclosure - Summary of Significant Accounting Policies (Policies)
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30203 - Disclosure - Summary of Significant Accounting Policies (Tables)
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31103 - Disclosure - Income Taxes (Tables)
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31203 - Disclosure - Commitments and Contingencies (Tables)
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40101 - Disclosure - Nature of Business (Details)
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40201 - Disclosure - Summary of Significant Accounting Policies - Property and Equipment (Details)
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40202 - Disclosure - Summary of Significant Accounting Policies - Basic and Diluted Loss Per Common Share (Details)
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40501 - Disclosure - Stockholders' Equity (Details)
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40601 - Disclosure - Stock-Based Compensation - Stock Option and Restricted Share Activity (Details)
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40801 - Disclosure - Co-Development and License Agreements (Details)
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40901 - Disclosure - Term Loans (Details)
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41001 - Disclosure - Restructurings - November 2015 and February 2016 (Details)
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41102 - Disclosure - Income Taxes - Net Operating Loss Carryforwards (Details)
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41103 - Disclosure - Income Taxes - Research & Development and Uncertain Tax Positions (Details)
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41301 - Disclosure - Related Party Transactions (Details)
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41401 - Disclosure - Retirement Plan (Details)
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41501 - Disclosure - Quarterly Financial Data (unaudited) (Details)
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