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MADRIGAL PHARMACEUTICALS, INC.
DE
04-3508648
Four Tower Bridge
200 Barr Harbor Drive, Suite 200
West Conshohocken
PA
19428
267
824-2827
Common Stock, $0.0001 Par Value Per Share
MDGL
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<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">1. Organization, Business and Basis of Presentation </div></div></div> <div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Organization and Business </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">Madrigal Pharmaceuticals, Inc. (the “Company” or “Madrigal”) is a clinical-stage pharmaceutical company developing novel, high-quality, small-molecule drugs addressing major unmet needs in cardiovascular, metabolic, and liver diseases. The Company’s lead compound, <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">MGL-3196</div> (resmetirom), is being advanced for <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">non-alcoholic</div> steatohepatitis (“NASH”), a liver disease that commonly affects people with metabolic diseases such as obesity and diabetes, and <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">non-alcoholic</div> fatty liver disease (“NAFLD”). The Company initiated two Phase 3 studies of resmetirom in NASH in 2019 that are ongoing. The Company previously completed Phase 2 studies of resmetirom in NASH in May of 2018 and Heterozygous Familial Hypercholesterolemia (“HeFH”) in February of 2018. </div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Madrigal was originally incorporated as a private company (“Private Madrigal”) on August 19, 2011 and operations commenced in September 2011. On July 22, 2016, Private Madrigal completed a reverse merger (the “Merger”) into Synta Pharmaceuticals Corp. (“Synta”). Upon the consummation of the Merger, the historical financial statements of Private Madrigal became the Company’s historical financial statements. </div></div>
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">2. Summary of Significant Accounting Policies </div></div></div> <div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Principle of Consolidation </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The consolidated financial statements include the financial statements of the Company and its wholly owned subsidiaries. All significant intercompany balances and transactions have been eliminated in consolidation. </div></div><div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Use of Estimates </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect certain reported amounts of assets and liabilities, and the reported amounts of revenues and expenses during the reporting periods. The Company bases its estimates on historical experience and various other assumptions that management believes to be reasonable under the circumstances. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates. </div></div><div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Cash and Cash Equivalents </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company considers all highly liquid investments with original maturities of three months or less at the date of purchase to be cash equivalents. The Company maintains its cash in bank accounts, the balance of which, at times, exceeds Federal Deposit Insurance Corporation insured limits. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The primary objective of the Company’s investment activities is to preserve its capital for the purpose of funding operations and the Company does not enter into investments for trading or speculative purposes. The Company’s cash is deposited in highly rated financial institutions in the United States. The Company invests in money market funds and high-grade, commercial paper and corporate bonds, which management believes are subject to minimal credit and market risk. </div></div><div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Marketable Securities </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">Marketable securities consist of investments in high-grade corporate obligations, and government and government agency obligations that are classified as <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">available-for-sale.</div></div> Since these securities are available to fund current operations they are classified as current assets on the consolidated balance sheets. </div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;">The Company adjusts the cost of <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">available-for-sale</div></div> debt securities for amortization of premiums and accretion of discounts to maturity. The Company includes such amortization and accretion as a component of interest income, net. Realized gains and losses and declines in value, if any, that the Company judges to be other-than-temporary on <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">available-for-sale</div></div> securities are reported as a component of interest income. To determine whether other-than-temporary impairment exists, the Company considers whether it intends to sell the debt security and, if the Company does not intend to sell the debt security, it considers available evidence to assess whether it is more likely than not that it will be required to sell the security before the recovery of its amortized cost basis. During the years ended December 31, 2020, 2019 and 2018, the Company determined it did not have any securities that were other-than-temporarily impaired. </div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Marketable securities are stated at fair value, including accrued interest, with their unrealized gains and losses included as a component of accumulated other comprehensive income or loss, which is a separate component of stockholders’ equity. The fair value of these securities is based on quoted prices and observable inputs on a recurring basis. Realized gains and losses are determined on the specific identification method. During the years ended December 31, 2020, 2019 and 2018, the Company did not have any realized gains or losses on marketable securities. </div></div> <div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Fair Value of Financial Instruments </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The carrying amounts of the Company’s financial instruments, which include cash equivalents, and marketable securities, approximate their fair values. The fair value of the Company’s financial instruments reflects the amounts that would be received upon sale of an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy has the following three levels: </div></div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Level 1—quoted prices in active markets for identical assets and liabilities. </div></div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Level 2—observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active. </div></div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Level 3—unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Financial assets and liabilities are classified in their entirety within the fair value hierarchy based on the lowest level of input that is significant to the fair value measurement. The Company measures the fair value of its marketable securities by taking into consideration valuations obtained from third-party pricing sources. The pricing services utilize industry standard valuation models, including both income and market-based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker-dealer quotes on the same or similar securities, issuer credit spreads, benchmark securities and other observable inputs. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">As of December 31, 2020 and 2019, the Company’s financial assets valued based on Level 1 inputs consisted of cash and cash equivalents in a money market fund and its financial assets valued based on Level 2 inputs consisted of high-grade corporate bonds and commercial paper. During the years ended December 31, 2020, 2019 and 2018, the Company did not have any transfers of financials assets between Levels 1 and 2. As of December 31, 2020 and 2019, the Company did not have any financial liabilities that were recorded at fair value on a recurring basis on the balance sheet. </div></div><div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Research and Development Costs </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">Research and development costs are expensed as incurred. Research and development costs are comprised of costs incurred in performing research and development activities, including internal costs (including stock-based compensation), costs for consultants, milestone payments under licensing agreements, and other costs associated with the Company’s preclinical and clinical programs. In particular, the Company has conducted safety studies in animals, optimized and implemented the manufacturing of our drug, and conducted Phase <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">1-3</div> clinical trials, all of which are considered research and development expenditures. Management uses significant judgment in estimating the amount of research and development costs recognized in each reporting period. Management analyzes and estimates the progress of its preclinical studies and clinical trials, completion of milestones events per underlying agreements, invoices received and contracted costs when estimating the research and development costs to accrue in each reporting period. Actual results could differ from the Company’s estimates. The Company’s historical estimates for research and development costs have not been materially different from the actual costs. </div><div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Patents </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Costs to secure and defend patents are expensed as incurred and are classified as general and administrative expense in the Company’s statements of operations. Patent expenses were approximately $353 thousand, $408 thousand and $226 thousand for the years ended December 31, 2020, 2019 and 2018, respectively. </div></div><div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock-Based Compensation </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company recognizes stock-based compensation expense based on the grant date fair value of stock options granted to employees, officers and directors. The Company uses the Black-Scholes option pricing model to determine the grant date fair value as management believes it is the most appropriate valuation method for its option grants. The Black-Scholes model requires inputs for risk-free interest rate, dividend yield, volatility and expected lives of the options. The expected lives for options granted represent the </div></div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">period of time that options granted are expected to be outstanding. The Company uses the simplified method for determining the expected lives of options. Expected volatility is based upon an industry estimate or blended rate including the Company’s historical trading activity. The risk-free rate for periods within the expected life of the option is based on the U.S. Treasury yield curve in effect at the time of the grant. The Company estimates the forfeiture rate based on historical data. This analysis is <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">re-evaluated</div> at least annually and the forfeiture rate is adjusted as necessary. </div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Certain of the employee stock options granted by the Company are structured to qualify as incentive stock options (ISOs). Under current tax regulations, the Company does not receive a tax deduction for the issuance, exercise or disposition of ISOs if the employee meets certain holding requirements. If the employee does not meet the holding requirements, a disqualifying disposition occurs, at which time the Company may receive a tax deduction. The Company does not record tax benefits related to ISOs unless and until a disqualifying disposition is reported. In the event of a disqualifying disposition, the entire tax benefit is recorded as a reduction of income tax expense. The Company has not recognized any income tax benefit for its share-based compensation arrangements due to the fact that the Company does not believe it is more likely than not it will realize the related deferred tax assets. </div></div> <div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Income Taxes </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company uses the asset and liability method to account for income taxes. Deferred tax assets and liabilities are determined based on the expected future tax consequences of temporary differences between the Company’s financial statement carrying amounts and the tax basis of assets and liabilities using enacted tax rates expected to be in effect in the years in which the differences are expected to reverse. The Company currently maintains a 100% valuation allowance on its deferred tax assets. </div></div><div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Comprehensive Loss </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">Comprehensive loss is defined as the change in equity of a business enterprise during a period from transactions and other events and circumstances from <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">non-owner</div> sources. Changes in unrealized gains and losses on marketable securities represent the only difference between the Company’s net loss and comprehensive loss. </div><div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic and Diluted Loss Per Common Share </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic net loss per share is computed using the weighted average number of common shares outstanding during the period, excluding restricted stock that has been issued but is not yet vested. Diluted net loss per common share is computed using the weighted average number of common shares outstanding and the weighted average dilutive potential common shares outstanding using the treasury stock method. However, for the years ended December 31, 2020, 2019 and 2018, diluted net loss per share is the same as basic net loss per share as the inclusion of weighted average shares of unvested restricted common stock and common stock issuable upon the exercise of stock options would be anti-dilutive. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The following table summarizes outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive: </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 84%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
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<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="10" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">As of December 31,</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
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<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2018</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-size: 1px;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Common stock options</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,837,540</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,461,987</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,132,618</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Unvested restricted common stock</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">52,063</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Preferred stock</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,969,797</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,969,797</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,969,797</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table> <div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Recent Accounting Pronouncements </div></div></div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt; margin-left: 4%;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">None. </div></div>
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Principle of Consolidation </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The consolidated financial statements include the financial statements of the Company and its wholly owned subsidiaries. All significant intercompany balances and transactions have been eliminated in consolidation. </div></div>
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Use of Estimates </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect certain reported amounts of assets and liabilities, and the reported amounts of revenues and expenses during the reporting periods. The Company bases its estimates on historical experience and various other assumptions that management believes to be reasonable under the circumstances. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates. </div></div>
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Cash and Cash Equivalents </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company considers all highly liquid investments with original maturities of three months or less at the date of purchase to be cash equivalents. The Company maintains its cash in bank accounts, the balance of which, at times, exceeds Federal Deposit Insurance Corporation insured limits. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The primary objective of the Company’s investment activities is to preserve its capital for the purpose of funding operations and the Company does not enter into investments for trading or speculative purposes. The Company’s cash is deposited in highly rated financial institutions in the United States. The Company invests in money market funds and high-grade, commercial paper and corporate bonds, which management believes are subject to minimal credit and market risk. </div></div>
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Marketable Securities </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">Marketable securities consist of investments in high-grade corporate obligations, and government and government agency obligations that are classified as <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">available-for-sale.</div></div> Since these securities are available to fund current operations they are classified as current assets on the consolidated balance sheets. </div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;">The Company adjusts the cost of <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">available-for-sale</div></div> debt securities for amortization of premiums and accretion of discounts to maturity. The Company includes such amortization and accretion as a component of interest income, net. Realized gains and losses and declines in value, if any, that the Company judges to be other-than-temporary on <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">available-for-sale</div></div> securities are reported as a component of interest income. To determine whether other-than-temporary impairment exists, the Company considers whether it intends to sell the debt security and, if the Company does not intend to sell the debt security, it considers available evidence to assess whether it is more likely than not that it will be required to sell the security before the recovery of its amortized cost basis. During the years ended December 31, 2020, 2019 and 2018, the Company determined it did not have any securities that were other-than-temporarily impaired. </div>Marketable securities are stated at fair value, including accrued interest, with their unrealized gains and losses included as a component of accumulated other comprehensive income or loss, which is a separate component of stockholders’ equity. The fair value of these securities is based on quoted prices and observable inputs on a recurring basis. Realized gains and losses are determined on the specific identification method. During the years ended December 31, 2020, 2019 and 2018, the Company did not have any realized gains or losses on marketable securities.
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Fair Value of Financial Instruments </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The carrying amounts of the Company’s financial instruments, which include cash equivalents, and marketable securities, approximate their fair values. The fair value of the Company’s financial instruments reflects the amounts that would be received upon sale of an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy has the following three levels: </div></div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Level 1—quoted prices in active markets for identical assets and liabilities. </div></div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Level 2—observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active. </div></div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Level 3—unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Financial assets and liabilities are classified in their entirety within the fair value hierarchy based on the lowest level of input that is significant to the fair value measurement. The Company measures the fair value of its marketable securities by taking into consideration valuations obtained from third-party pricing sources. The pricing services utilize industry standard valuation models, including both income and market-based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker-dealer quotes on the same or similar securities, issuer credit spreads, benchmark securities and other observable inputs. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">As of December 31, 2020 and 2019, the Company’s financial assets valued based on Level 1 inputs consisted of cash and cash equivalents in a money market fund and its financial assets valued based on Level 2 inputs consisted of high-grade corporate bonds and commercial paper. During the years ended December 31, 2020, 2019 and 2018, the Company did not have any transfers of financials assets between Levels 1 and 2. As of December 31, 2020 and 2019, the Company did not have any financial liabilities that were recorded at fair value on a recurring basis on the balance sheet. </div></div>
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Research and Development Costs </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">Research and development costs are expensed as incurred. Research and development costs are comprised of costs incurred in performing research and development activities, including internal costs (including stock-based compensation), costs for consultants, milestone payments under licensing agreements, and other costs associated with the Company’s preclinical and clinical programs. In particular, the Company has conducted safety studies in animals, optimized and implemented the manufacturing of our drug, and conducted Phase <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">1-3</div> clinical trials, all of which are considered research and development expenditures. Management uses significant judgment in estimating the amount of research and development costs recognized in each reporting period. Management analyzes and estimates the progress of its preclinical studies and clinical trials, completion of milestones events per underlying agreements, invoices received and contracted costs when estimating the research and development costs to accrue in each reporting period. Actual results could differ from the Company’s estimates. The Company’s historical estimates for research and development costs have not been materially different from the actual costs. </div>
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Patents </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Costs to secure and defend patents are expensed as incurred and are classified as general and administrative expense in the Company’s statements of operations. Patent expenses were approximately $353 thousand, $408 thousand and $226 thousand for the years ended December 31, 2020, 2019 and 2018, respectively. </div></div>
353000
408000
226000
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock-Based Compensation </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company recognizes stock-based compensation expense based on the grant date fair value of stock options granted to employees, officers and directors. The Company uses the Black-Scholes option pricing model to determine the grant date fair value as management believes it is the most appropriate valuation method for its option grants. The Black-Scholes model requires inputs for risk-free interest rate, dividend yield, volatility and expected lives of the options. The expected lives for options granted represent the </div></div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">period of time that options granted are expected to be outstanding. The Company uses the simplified method for determining the expected lives of options. Expected volatility is based upon an industry estimate or blended rate including the Company’s historical trading activity. The risk-free rate for periods within the expected life of the option is based on the U.S. Treasury yield curve in effect at the time of the grant. The Company estimates the forfeiture rate based on historical data. This analysis is <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">re-evaluated</div> at least annually and the forfeiture rate is adjusted as necessary. </div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Certain of the employee stock options granted by the Company are structured to qualify as incentive stock options (ISOs). Under current tax regulations, the Company does not receive a tax deduction for the issuance, exercise or disposition of ISOs if the employee meets certain holding requirements. If the employee does not meet the holding requirements, a disqualifying disposition occurs, at which time the Company may receive a tax deduction. The Company does not record tax benefits related to ISOs unless and until a disqualifying disposition is reported. In the event of a disqualifying disposition, the entire tax benefit is recorded as a reduction of income tax expense. The Company has not recognized any income tax benefit for its share-based compensation arrangements due to the fact that the Company does not believe it is more likely than not it will realize the related deferred tax assets. </div></div>
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Income Taxes </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company uses the asset and liability method to account for income taxes. Deferred tax assets and liabilities are determined based on the expected future tax consequences of temporary differences between the Company’s financial statement carrying amounts and the tax basis of assets and liabilities using enacted tax rates expected to be in effect in the years in which the differences are expected to reverse. The Company currently maintains a 100% valuation allowance on its deferred tax assets. </div></div>
1
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Comprehensive Loss </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">Comprehensive loss is defined as the change in equity of a business enterprise during a period from transactions and other events and circumstances from <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">non-owner</div> sources. Changes in unrealized gains and losses on marketable securities represent the only difference between the Company’s net loss and comprehensive loss. </div>
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic and Diluted Loss Per Common Share </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic net loss per share is computed using the weighted average number of common shares outstanding during the period, excluding restricted stock that has been issued but is not yet vested. Diluted net loss per common share is computed using the weighted average number of common shares outstanding and the weighted average dilutive potential common shares outstanding using the treasury stock method. However, for the years ended December 31, 2020, 2019 and 2018, diluted net loss per share is the same as basic net loss per share as the inclusion of weighted average shares of unvested restricted common stock and common stock issuable upon the exercise of stock options would be anti-dilutive. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The following table summarizes outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive: </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 84%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 67%;"/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="10" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">As of December 31,</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2018</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-size: 1px;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Common stock options</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,837,540</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,461,987</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,132,618</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Unvested restricted common stock</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">52,063</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Preferred stock</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,969,797</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,969,797</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,969,797</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 84%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 67%;"/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="10" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">As of December 31,</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2018</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-size: 1px;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Common stock options</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,837,540</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,461,987</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,132,618</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Unvested restricted common stock</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">52,063</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Preferred stock</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,969,797</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,969,797</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,969,797</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table>
1837540
1461987
1132618
52063
1969797
1969797
1969797
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Recent Accounting Pronouncements </div></div></div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt; margin-left: 4%;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">None. </div></div>
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">3. Liquidity and Uncertainties </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">The Company is subject to risks common to development stage companies in the <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">Bio-Pharmaceutical</div> industry including, but not limited to, uncertainty of product development and commercialization, dependence on key personnel, uncertainty of market acceptance of products and product reimbursement, product liability, uncertain protection of proprietary technology, potential inability to raise additional financing necessary for development and commercialization, and compliance with the U.S. Food and Drug Administration and other government regulations. </div> <div style="font-size: 8pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 8pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company has incurred losses since inception, including approximately $202.2 million for the year ended December 31, 2020, resulting in an accumulated deficit of approximately $425.5 million and $223.2 million as of December 31, 2020 and 2019, respectively. Management expects to incur losses for the foreseeable future. To date, the Company has funded its operations primarily through the issuance of convertible debt, the proceeds from the Merger on July 22, 2016, and proceeds from sales of the Company’s common and Series A Convertible Preferred Stock (see Note 6). </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company believes that its cash, cash equivalents and marketable securities at December 31, 2020 will be sufficient to fund operations past one year from the issuance of these financial statements. To meet its future capital needs, the Company intends to raise additional capital through debt or equity financings, collaborations, partnerships or other strategic transactions. However, there can be no assurance that the Company will be able to complete any such transactions on acceptable terms or otherwise. The inability of the Company to obtain sufficient funds on acceptable terms when needed could have a material adverse effect on the Company’s business, results of operations and financial condition. The Company has the ability to delay certain research activities and related clinical expenses if necessary due to liquidity concerns until a date in which those concerns are relieved. </div></div>
-202200000
-425500000
-223200000
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">4. Cash, Cash Equivalents and Marketable Securities </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">A summary of cash, cash equivalents and <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">available-for-sale</div></div> marketable securities held by the Company as of December 31, 2020 and 2019 is as follows (in thousands): </div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 92%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 63%;"/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 4%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="14" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31, 2020</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Cost</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Unrealized</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">gains</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Unrealized</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">losses</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Fair</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">value</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Cash and cash equivalents:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Cash (Level 1)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">716</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">716</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Money market funds (Level 1)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">53,288</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">53,288</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total cash and cash equivalents</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">54,004</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">54,004</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Marketable securities:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Corporate debt securities due within 1 year of date of purchase (Level 2)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">227,172</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">80</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(36</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">227,216</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Corporate debt securities due within 1 to 2 years of date of purchase (Level 2)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,926</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(1</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,929</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total cash, cash equivalents and marketable securities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">284,102</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">84</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(37</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">284,149</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-size: 1pt;">
<td style="height: 12pt; font-family: "Times New Roman";"> </td>
<td colspan="16" style="height: 12pt; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="14" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31, 2019</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Cost</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Unrealized</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">gains</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Unrealized</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">losses</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Fair</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">value</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Cash and cash equivalents:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Cash (Level 1)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,772</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,772</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Money market funds (Level 1)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">44,925</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">44,925</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total cash and cash equivalents</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">46,697</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">46,697</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Marketable securities:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Corporate debt securities due within 1 year of date of purchase (Level 2)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">309,365</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">220</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(40</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">309,545</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Corporate debt securities due within 1 to 2 years of date of purchase (Level 2)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">82,767</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">39</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">82,803</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total cash, cash equivalents and marketable securities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">438,829</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">259</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(43</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">439,045</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr></table>
<div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">A summary of cash, cash equivalents and <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">available-for-sale</div></div> marketable securities held by the Company as of December 31, 2020 and 2019 is as follows (in thousands): </div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 92%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 63%;"/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 4%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="14" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31, 2020</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Cost</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Unrealized</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">gains</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Unrealized</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">losses</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Fair</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">value</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Cash and cash equivalents:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Cash (Level 1)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">716</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">716</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Money market funds (Level 1)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">53,288</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">53,288</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total cash and cash equivalents</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">54,004</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">54,004</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Marketable securities:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Corporate debt securities due within 1 year of date of purchase (Level 2)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">227,172</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">80</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(36</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">227,216</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Corporate debt securities due within 1 to 2 years of date of purchase (Level 2)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,926</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(1</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,929</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total cash, cash equivalents and marketable securities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">284,102</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">84</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(37</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">284,149</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-size: 1pt;">
<td style="height: 12pt; font-family: "Times New Roman";"> </td>
<td colspan="16" style="height: 12pt; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="14" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31, 2019</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Cost</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Unrealized</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">gains</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Unrealized</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">losses</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Fair</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">value</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Cash and cash equivalents:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Cash (Level 1)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,772</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,772</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Money market funds (Level 1)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">44,925</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">44,925</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total cash and cash equivalents</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">46,697</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">46,697</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Marketable securities:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Corporate debt securities due within 1 year of date of purchase (Level 2)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">309,365</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">220</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(40</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">309,545</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Corporate debt securities due within 1 to 2 years of date of purchase (Level 2)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">82,767</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">39</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">82,803</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total cash, cash equivalents and marketable securities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">438,829</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">259</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(43</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">439,045</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr></table>
716000
716000
53288000
53288000
54004000
54004000
P1Y
227172000
80000
36000
227216000
P1Y
P2Y
2926000
4000
1000
2929000
284102000
84000
37000
284149000
1772000
1772000
44925000
44925000
46697000
46697000
P1Y
309365000
220000
40000
309545000
P1Y
P2Y
82767000
39000
3000
82803000
438829000
259000
43000
439045000
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">5. Accrued Liabilities </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Accrued liabilities as of December 31, 2020 and 2019 consisted of the following (in thousands): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 76%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 74%;"/>
<td style="width: 7%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 7%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31,</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31,</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Contract research organization costs</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">31,646</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">13,775</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other clinical study related costs</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,901</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,621</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Compensation and benefits</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4,686</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,779</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Professional fees</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">830</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,177</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4,159</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,285</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total accrued liabilities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">45,222</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">23,637</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr></table>
<div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Accrued liabilities as of December 31, 2020 and 2019 consisted of the following (in thousands): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 76%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 74%;"/>
<td style="width: 7%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 7%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31,</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31,</div></div><br/> <div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Contract research organization costs</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">31,646</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">13,775</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other clinical study related costs</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,901</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,621</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Compensation and benefits</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4,686</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,779</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Professional fees</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">830</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,177</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4,159</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,285</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total accrued liabilities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">45,222</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">23,637</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr></table>
31646000
13775000
3901000
2621000
4686000
2779000
830000
1177000
4159000
3285000
45222000
23637000
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">6. Stockholders’ Equity </div></div></div> <div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Common Stock </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Each common stockholder is entitled to one vote for each share of common stock held. The common stock will vote together with all other classes and series of stock of the Company as a single class on all actions to be taken by the Company’s stockholders. Each share of common stock is entitled to receive dividends, as and when declared by the Company’s board of directors. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company has never declared cash dividends on its common stock and does not expect to do so in the foreseeable future. </div></div> <div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Preferred Stock </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">The Series A Preferred Stock has a par value of $0.0001 per share and is convertible into shares of the common stock at a <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">one-to-one</div></div> ratio, subject to adjustment as provided in the Certificate of Designation of Preferences, Rights and Limitations of Series A Convertible Preferred Stock, that the Company filed with the Secretary of State of the State of Delaware on June 21, 2017 (the “Series A Certificate”). The terms of the Series A Preferred Stock are set forth in the Series A Certificate. Each share of the Series A Preferred Stock is convertible into shares of Common Stock following notice that may be given at the holder’s option. Upon any liquidation, dissolution or <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">winding-up</div> of the Company, whether voluntary or involuntary, after the satisfaction in full of the debts of the Company and the payment of any liquidation preference owed to the holders of shares of capital stock of the Company ranking prior to the Series A Preferred Stock upon liquidation, the holders of the Series A Preferred Stock shall participate pari passu with the holders of the Common Stock (on an <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">as-if-converted-to-Common-Stock</div></div></div></div> basis) in the net assets of the Company. Shares of the Series A Preferred Stock will generally have no voting rights, except as required by law. Shares of the Series A Preferred Stock will be entitled to receive dividends before shares of any other class or series of capital stock of the Company (other than dividends in the form of the Common Stock) equal to the dividend payable on each share of the Common Stock, on an <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">as-converted</div> basis. </div> <div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-style: normal; letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-style:italic;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">At-The-Market</div></div> Issuance Sales Agreement </div></div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">In November 2020, the Company entered into an <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">at-the-market</div></div> sales agreement (the “2020 Sales Agreement”), with Cowen and Company, LLC (“Cowen”), pursuant to which the Company may, from time to time, issue and sell shares of its common stock. The Company is not obligated to make any sales of its common stock under the 2020 Sales Agreement. Any shares sold will be sold pursuant to <div style="display:inline;">the</div> effective shelf registration statement on Form <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">S-3,</div> (the “Registration Statement”), and <div style="display:inline;">the</div> prospectus supplement to the Registration Statement. The Sales Agreement authorizes an aggregate offering of up to $200 million in shares of our common stock, from time to time, at the Company’s option, through Cowen as its sales agent. Sales of common stock through Cowen may be made by any method that is deemed an <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">“at-the-market”</div></div> offering as defined in Rule 415 promulgated under the Securities Act of 1933, as amended, including by means of ordinary brokers’ transactions at market prices, in block transactions or as otherwise agreed by the Company and Cowen. Subject to the terms and conditions of the 2020 Sales Agreement, Cowen will use commercially reasonable efforts consistent with its normal trading and sales practices to sell the common stock based upon the Company’s instructions (including any price, time or size limits or other customary parameters or conditions the Company may impose). The 2020 Sales Agreement may be terminated by the Company at any time upon 10 days’ notice. </div><div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">As of December 31, 2020, 39,607 shares have been sold under the 2020 Sales Agreement for an aggregate of approximately $4.8 million in gross proceeds. Net proceeds to the Company were approximately $4.4 million after deducting commissions and other transaction costs. Approximately $195.2 million remained reserved under the Company’s shelf registration statement and the applicable prospectus supplement for possible future issuance under the 2020 Sales Agreement. </div></div><div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-style: normal; letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-style:italic;display:inline;">June 2018 Registered Offering of Common Stock </div></div></div></div><div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">In June 2018, the Company entered into an underwriting agreement with Goldman Sachs & Co. LLC, as representative of the several underwriters named therein (the “June 2018 Underwriters”), relating to an underwritten public offering (the “June 2018 Offering”) of 1,079,580 shares of the Company’s common stock, including 95,973 shares of the Company’s common stock purchased by the June 2018 Underwriters pursuant to a <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">30-day</div> option to purchase such additional shares granted therein, at a public offering price of $305.00 per share. The June 2018 Offering resulted in gross proceeds to the Company of approximately $329.3 million, and net proceeds to the Company of approximately $311.8 million, after deducting the June 2018 Underwriters’ discount and other offering costs. The June 2018 Offering closed on June 11, 2018. </div>
1
0.0001
1
0
200000000
P10D
39607
4800000
4400000
195200000
1079580
95973
P30D
305.00
329300000
311800000
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">7. Stock-based Compensation </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">The 2015 Stock Plan, as amended, is our primary plan through which equity based grants are awarded. We ceased making new awards under the 2006 Stock Plan upon adoption of the 2015 Stock Plan. The 2015 Stock Plan provides for the grant of incentive stock options, <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">non-statutory</div> stock options, restricted stock and other stock-based compensation awards to employees, officers, directors, and consultants of the Company. The administration of the 2015 Stock Plan is under the general supervision of the Compensation Committee of the Board of Directors. The terms of stock options awarded under the 2015 Stock Plan, in general, are determined by the Compensation Committee, provided the exercise price per share generally shall not be set at less than the fair market value of a share of the common stock on the date of grant and the term shall not be greater than ten years from the date the option is granted. As of December 31, 2020, the Company had options outstanding to purchase 1,837,540 shares of its common stock, which includes options outstanding under its 2006 Stock Plan. As of December 31, 2020, 936,407 shares were available for future issuance. </div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The following table summarizes stock option activity during the twelve months ended December 31, 2020: </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 92%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 56%;"/>
<td style="width: 6%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 6%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 6%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Shares</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Weighted<br/> average exercise<br/> price</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Weighted<br/> average<br/> remaining<br/> contractual life<br/> (years)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Aggregate<br/> intrinsic value<br/> (in thousands)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Outstanding at January 1, 2020</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,461,987</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">64.67</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Options granted</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">449,625</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">92.51</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Options exercised</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(39,385</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">16.94</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Options cancelled</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(34,687</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">102.35</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Outstanding at December 31, 2020</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,837,540</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">71.80</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">6.95</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">91,776</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Exercisable at December 31, 2020</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,185,889</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">55.24</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">6.09</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">82,075</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The total cash received by the Company as a result of stock option exercises was $0.7 million, $0.2 million and $2.5 million for the years ended December 31, 2020, 2019, and 2018. The total intrinsic value of options exercised was $4.1 million in the year ended December 31, 2020. The weighted-average grant date fair values, based on the Black-Scholes option model, of options granted during the year ended December 31, 2020, 2019 and 2018 was $68.07, $91.19 and $137.49, respectively. </div></div> <div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-style: normal; letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-style:italic;display:inline;">Restricted Common Stock </div></div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company’s share-based compensation plan provides for awards of restricted shares of common stock to employees, officers, directors and consultants to the Company. Restricted stock awards are subject to forfeiture if employment or service terminates during the prescribed retention period. Restricted shares vest over the service period. There were no outstanding restricted shares or activity in 2020. </div></div> <div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock-Based Compensation Expense </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock-based compensation expense during the years ended December 31, 2020, 2019 and 2018 was as follows (in thousands): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 84%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 73%;"/>
<td style="width: 3%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 3%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 3%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="10" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Years Ended December 31,</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2018</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock-based compensation expense by type of award:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock options</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">20,730</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">22,487</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">12,997</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Restricted stock</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">272</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">492</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total stock-based compensation expense</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">20,730</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">22,759</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">13,489</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-size: 1pt;">
<td style="height: 6pt; font-family: "Times New Roman";"> </td>
<td colspan="4" style="height: 6pt; font-family: "Times New Roman";"> </td>
<td colspan="4" style="height: 6pt; font-family: "Times New Roman";"> </td>
<td colspan="4" style="height: 6pt; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Effect of stock-based compensation expense by line item:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Research and development</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">8,833</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">8,277</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,707</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">General and administrative</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">11,897</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14,482</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">9,782</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total stock-based compensation expense included in net loss</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">20,730</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">22,759</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">13,489</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr></table> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Unrecognized stock-based compensation expense on stock options as of December 31, 2020 was $38.8 million with a weighted average remaining period of 2.6 years. </div></div>
P10Y
1837540
936407
<div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The following table summarizes stock option activity during the twelve months ended December 31, 2020: </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 92%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 56%;"/>
<td style="width: 6%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 6%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 6%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Shares</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Weighted<br/> average exercise<br/> price</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Weighted<br/> average<br/> remaining<br/> contractual life<br/> (years)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Aggregate<br/> intrinsic value<br/> (in thousands)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Outstanding at January 1, 2020</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,461,987</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">64.67</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Options granted</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">449,625</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">92.51</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Options exercised</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(39,385</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">16.94</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Options cancelled</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(34,687</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">102.35</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"><div style="letter-spacing: 0px; top: 0px;;display:inline;">— </div></td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Outstanding at December 31, 2020</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,837,540</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">71.80</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">6.95</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">91,776</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Exercisable at December 31, 2020</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,185,889</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">55.24</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">6.09</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">82,075</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table>
1461987
64.67
449625
92.51
39385
16.94
34687
102.35
1837540
71.80
P6Y11M12D
91776000
1185889
55.24
P6Y1M2D
82075000
700000
200000
2500000
4100000
68.07
91.19
137.49
0
<div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock-based compensation expense during the years ended December 31, 2020, 2019 and 2018 was as follows (in thousands): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 84%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 73%;"/>
<td style="width: 3%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 3%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 3%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="10" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Years Ended December 31,</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2018</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock-based compensation expense by type of award:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock options</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">20,730</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">22,487</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">12,997</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Restricted stock</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">272</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">492</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total stock-based compensation expense</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">20,730</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">22,759</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">13,489</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-size: 1pt;">
<td style="height: 6pt; font-family: "Times New Roman";"> </td>
<td colspan="4" style="height: 6pt; font-family: "Times New Roman";"> </td>
<td colspan="4" style="height: 6pt; font-family: "Times New Roman";"> </td>
<td colspan="4" style="height: 6pt; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Effect of stock-based compensation expense by line item:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Research and development</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">8,833</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">8,277</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,707</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">General and administrative</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">11,897</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14,482</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">9,782</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total stock-based compensation expense included in net loss</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">20,730</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">22,759</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">13,489</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr></table>
20730000
22487000
12997000
272000
492000
20730000
22759000
13489000
8833000
8277000
3707000
11897000
14482000
9782000
20730000
22759000
13489000
38800000
P2Y7M6D
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">8. Leases </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">In 2019, the Company entered into an operating lease for office space, which was renewed and extended in 2020. We adopted ASU <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">2016-02,</div> “Leases,” on January 1, 2019 requiring, among other changes, operating and finance leases with terms exceeding twelve months to be recognized as a <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">right-of-use</div></div> asset (or “ROU”) and lease liabilities on the balance sheet. Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The lease term is determined to be the <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">non-cancelable</div> period including any lessee renewal options that are considered reasonably certain of exercise. The interest rate implicit in lease contracts is typically not readily determinable. As such, the Company used judgment to determine an appropriate incremental borrowing rate, which is the rate incurred to borrow on a collateralized basis over a similar term in a similar economic environment. </div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Future minimum payments under the Company’s operating leases related to the ROU asset and lease liability as of December 31, 2020 was as follows (in thousand): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 68%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 88%;"/>
<td style="width: 8%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Operating<br/> Leases</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-size: 1px;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">2021</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">370</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">2022</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">371</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">2023</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">155</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Thereafter</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total minimum payments</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">896</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Less: imputed interest</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">110</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Present value of lease liabilities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">786</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">As of December 31, 2020, the weighted average remaining operating lease term was 2.4 years and the weighted average discount rate used to determine the operating lease liabilities was 3.25%. Cash paid related to the lease liability was $303 and $297 thousand for years ended December 31, 2020 and 2019 respectively. Operating lease costs during the year ended December 31, 2020 was $347 and $386 thousand for years ended December 31, 2020 and 2019 respectively. Rent expense during the year ended December 31, 2020 and 2019 was $0 thousand and $239 thousand, respectively. Short term and variable leases costs were immaterial during the years ended December 31, 2020, 2019 and 2018. </div></div>
<div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Future minimum payments under the Company’s operating leases related to the ROU asset and lease liability as of December 31, 2020 was as follows (in thousand): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 68%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 88%;"/>
<td style="width: 8%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Operating<br/> Leases</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-size: 1px;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">2021</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">370</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">2022</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">371</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">2023</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">155</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Thereafter</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total minimum payments</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">896</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Less: imputed interest</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">110</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Present value of lease liabilities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">786</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table>
370000
371000
155000
896000
110000
786000
P2Y4M24D
0.0325
303000
297000
347000
386000
0
239000
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">9. Commitments and Contingencies </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;">The Company has a Research, Development and Commercialization Agreement with <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">Hoffmann-La</div> Roche (“Roche”) which grants the Company a sole and exclusive license to develop, use, sell, offer for sale and import any Licensed Product as defined by the agreement. </div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;">The agreement requires future milestone payments to Roche. In 2019, the Company commenced a Phase 3 study in <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;;display:inline;">Non-Alcoholic</div> Steatohepatitis (NASH), which triggered a $2 million milestone payment under the agreement. Remaining milestones under </div> <div style="font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">the agreement total $8 million and are earned by achieving specified objectives related to future regulatory approval in the United States and Europe of a product developed from resmetirom. A single-digit royalty payment range is based on net sales of products developed from resmetirom, subject to certain reductions. Except as described above, the Company has not achieved any additional product development or regulatory milestones and had no Licensed Product sales for the years ended December 31, 2020, 2019 and 2018. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Company has entered into customary contractual arrangements and letters of intent in preparation for and in support of the Phase 3 clinical trials. </div></div>
2000000
8000000
0
0
0
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">10. Income Taxes</div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">At December 31, 2020, the Company had federal net operating loss (“NOL”) carryforwards of approximately $99.9 million available to reduce future taxable income, of which $40.4 million will expire between 2031 and 2037. The Company also has state operating loss carryforwards of approximately $88.6 million, available to reduce future taxable income, which expire between 2031 and 2040. The Company has unused federal research and development carryforwards of approximately $13.4 million which will begin to expire in 2031. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The Internal Revenue Code (“IRC”) limits the amounts of NOL carryforwards that a Company may use in any one year in the event of certain cumulative changes in ownership over a three-year period as described in Section 382 of the IRC. Such change in ownership could limit the Company’s utilization of the NOL, and could be triggered by subsequent sales of securities by the Company or stockholders. The deferred tax asset related to the NOL reflected on the financial statements could be affected by this limitation. Although a formal analysis has not been completed, the Company has determined that an ownership change likely occurred for Madrigal during the year ended December 31, 2017. The net operating losses are expected to be subject to an annual limitation; however, none of these NOLs is expected to expire before becoming available to reduce future taxable income. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">In assessing the realizability of deferred tax assets, management considers whether it is more likely than not that some portion of the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income during the periods in which those temporary differences become deductible. As there is no assurance of future taxable income, a full valuation allowance has been established to offset the deferred tax assets. The valuation allowance increased $66.6 million for the year ended December 31, 2020. Changes in the deferred tax asset will be recorded as an income tax benefit or expense on the accompanying consolidated statements of operations. </div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Entities are also required to evaluate, measure, recognize and disclose any uncertain income tax provisions taken on their income tax returns. The Company has analyzed its tax positions and has concluded that as of December 31, 2020 there were no uncertain positions. The 2016 through 2020 tax returns are open to review by the IRS and state taxing authorities. Interest and penalties, if any, as they relate to income taxes assessed, are included in the income tax provision. There was no income tax related interest and penalties included in the income tax provision for 2020. </div></div><div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Temporary differences that give rise to deferred tax assets and liabilities are as follows (in thousands): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 84%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 84%;"/>
<td style="width: 3%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="10" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">For the years ended December 31,</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2018</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Deferred Tax Liabilities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Unrealized gains on investments</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">62</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total Deferred Tax Liabilities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">62</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Deferred Tax Assets</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Charitable contributions</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">51</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">13</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Accrued expenses</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,318</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">759</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">498</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Intangibles</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">883</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">983</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">477</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock compensation</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">16,812</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">10,943</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4,395</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Property, plant & equipment</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">68</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">13</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">9</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Unrealized loss on investment</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">92</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net operating losses</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">27,933</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">17,635</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14,851</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Capitalized R&D</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">71,128</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">29,364</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,108</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">R&D credit</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14,205</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">6,141</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,505</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total deferred tax assets before valuation allowance</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">132,398</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">65,853</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">38,948</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Valuation allowance</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(132,384</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(65,791</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(38,948</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total deferred tax assets</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">62</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net deferred tax assets</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap; width: 6%; padding: 0pt 4pt 0pt 0pt;;text-align:right;">—</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr></table> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Differences between the effective income tax rate and the US statutory rate were as follows (in thousands): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 84%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 84%;"/>
<td style="width: 3%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="10" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">For the years ended December 31,</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2018</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Tax benefit at U.S. federal statutory rate</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"> (42,471</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"> (17,629</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"> (6,890</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock based compensation</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(68</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(47</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3,415</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other nondeductible expenses</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">State income taxes benefit before valuation allowance, net of federal benefit</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(16,580</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(6,613</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(5,460</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Increase in domestic valuation allowance</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">66,593</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">26,843</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">17,529</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Research and development credit</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(7,472</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(2,636</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(1,604</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other adjustments</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">68</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(160</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Income tax expense (benefit)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr></table>
99900000
40400000
88600000
13400000
66600000
0
0
<div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Temporary differences that give rise to deferred tax assets and liabilities are as follows (in thousands): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 84%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 84%;"/>
<td style="width: 3%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="10" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">For the years ended December 31,</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2018</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Deferred Tax Liabilities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Unrealized gains on investments</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">62</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total Deferred Tax Liabilities</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">62</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Deferred Tax Assets</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Charitable contributions</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">51</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">13</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Accrued expenses</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,318</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">759</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">498</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Intangibles</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">883</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">983</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">477</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock compensation</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">16,812</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">10,943</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4,395</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Property, plant & equipment</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">68</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">13</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">9</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Unrealized loss on investment</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">92</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net operating losses</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">27,933</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">17,635</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14,851</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Capitalized R&D</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">71,128</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">29,364</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,108</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">R&D credit</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14,205</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">6,141</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,505</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total deferred tax assets before valuation allowance</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">132,398</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">65,853</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">38,948</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Valuation allowance</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(132,384</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(65,791</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(38,948</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total deferred tax assets</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">62</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net deferred tax assets</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap; width: 6%; padding: 0pt 4pt 0pt 0pt;;text-align:right;">—</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr></table>
14000
62000
14000
62000
51000
15000
13000
1318000
759000
498000
883000
983000
477000
16812000
10943000
4395000
68000
13000
9000
92000
27933000
17635000
14851000
71128000
29364000
15108000
14205000
6141000
3505000
132398000
65853000
38948000
132384000
65791000
38948000
14000
62000
<div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 12pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Differences between the effective income tax rate and the US statutory rate were as follows (in thousands): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 84%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 84%;"/>
<td style="width: 3%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 2%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="10" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">For the years ended December 31,</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2020</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2019</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">2018</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Tax benefit at U.S. federal statutory rate</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"> (42,471</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"> (17,629</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;"> (6,890</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Stock based compensation</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(68</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(47</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3,415</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other nondeductible expenses</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">14</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">State income taxes benefit before valuation allowance, net of federal benefit</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(16,580</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(6,613</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(5,460</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Increase in domestic valuation allowance</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">66,593</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">26,843</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">17,529</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Research and development credit</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(7,472</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(2,636</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(1,604</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other adjustments</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">68</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(160</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Income tax expense (benefit)</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr></table>
-42471000
-17629000
-6890000
-68000
-47000
-3415000
1000
14000
-16580000
-6613000
-5460000
66593000
26843000
17529000
7472000
2636000
1604000
-3000
68000
-160000
0
0
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">11. Quarterly Financial Data (unaudited) </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The following tables present a summary of quarterly results of operations for 2020 and 2019 (in thousands, except shares and per share data): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 92%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 51%;"/>
<td style="width: 6%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="14" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Three months ended</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">March 31, 2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">June 30, 2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">September 30,<br/> 2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31,<br/> 2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-size: 1px;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Revenues:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total revenues</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Operating expenses:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Research and development</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">33,400</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">44,688</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">53,292</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">53,429</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">General and administrative</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4,605</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">5,639</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">5,494</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">6,126</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total operating expenses</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">38,005</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">50,327</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">58,786</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">59,555</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Loss from operations</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(38,005</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(50,327</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(58,786</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(59,555</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Interest income</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,870</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,204</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">823</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">432</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other income</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">100</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net loss</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(36,135</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(49,023</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(57,963</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(59,123</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net loss per common share:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic and diluted net loss per common share</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(2.34</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3.18</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3.75</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3.82</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic and diluted weighted average number of common shares outstanding</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,429,154</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,433,348</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,448,425</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,475,291</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table> <div style="clear: both; max-height: 0px; background: none;"/> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 92%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 51%;"/>
<td style="width: 6%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="14" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Three months ended</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">March 31, 2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">June 30, 2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">September 30,<br/> 2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31,<br/> 2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-size: 1px;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Revenues:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total revenues</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Operating expenses:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Research and development</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">12,373</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,594</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">19,447</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">24,910</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">General and administrative</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">5,746</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">7,110</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4,748</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">5,044</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total operating expenses</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">18,119</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">22,704</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">24,195</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">29,954</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Loss from operations</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(18,119</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(22,704</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(24,195</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(29,954</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Interest income</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,039</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,005</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,766</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,214</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other income</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net loss</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(15,080</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(19,699</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(21,429</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(27,740</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net loss per common share:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic and diluted net loss per common share</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(0.98</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(1.28</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(1.39</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(1.80</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic and diluted weighted average number of common shares outstanding</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,364,465</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,368,986</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,415,096</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,429,154</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table>
<div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">The following tables present a summary of quarterly results of operations for 2020 and 2019 (in thousands, except shares and per share data): </div></div> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 92%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 51%;"/>
<td style="width: 6%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="14" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Three months ended</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">March 31, 2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">June 30, 2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">September 30,<br/> 2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31,<br/> 2020</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-size: 1px;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Revenues:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total revenues</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Operating expenses:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Research and development</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">33,400</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">44,688</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">53,292</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">53,429</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">General and administrative</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4,605</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">5,639</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">5,494</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">6,126</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total operating expenses</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">38,005</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">50,327</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">58,786</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">59,555</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Loss from operations</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(38,005</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(50,327</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(58,786</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(59,555</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Interest income</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,870</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">1,204</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">823</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">432</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other income</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">100</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net loss</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(36,135</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(49,023</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(57,963</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(59,123</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net loss per common share:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic and diluted net loss per common share</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(2.34</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3.18</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3.75</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(3.82</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic and diluted weighted average number of common shares outstanding</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,429,154</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,433,348</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,448,425</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,475,291</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table> <div style="clear: both; max-height: 0px; background: none;"/> <div style="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt;"><div style="font-size: 12pt; letter-spacing: 0px; top: 0px;;display:inline;"> </div></div>
<table cellpadding="0" cellspacing="0" style="margin: 0px auto; border: 0px currentcolor; width: 92%; font-family: "Times New Roman"; font-size: 10pt; border-collapse: collapse; border-spacing: 0px;">
<tr style="font-size: 0px;">
<td style="width: 51%;"/>
<td style="width: 6%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/>
<td style="width: 5%; vertical-align: bottom;"/>
<td/>
<td/>
<td/></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="14" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">Three months ended</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 8pt; page-break-inside: avoid;">
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">March 31, 2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">June 30, 2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">September 30,<br/> 2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td>
<td colspan="2" rowspan="2" style="vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1pt; border-bottom-style: solid;;text-align:center;"><div style="letter-spacing: 0px; top: 0px;;display:inline;"><div style="font-weight:bold;display:inline;">December 31,<br/> 2019</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 1pt;"> </td></tr>
<tr style="font-size: 1px;">
<td style="font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Revenues:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total revenues</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Operating expenses:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Research and development</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">12,373</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,594</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">19,447</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">24,910</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">General and administrative</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">5,746</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">7,110</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">4,748</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">5,044</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Total operating expenses</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">18,119</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">22,704</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">24,195</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">29,954</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Loss from operations</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(18,119</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(22,704</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(24,195</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(29,954</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Interest income</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,039</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">3,005</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,766</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">2,214</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Other income</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">— </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 1px solid rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 3em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net loss</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(15,080</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(19,699</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(21,429</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(27,740</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-size: 1px;">
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td style="vertical-align: bottom;"><div style="margin-top: 0px; margin-bottom: 0px; border-top: 3px double rgb(0, 0, 0); line-height: normal;"> </div></td>
<td> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Net loss per common share:</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td>
<td style="vertical-align: bottom; font-family: "Times New Roman";"> </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid;">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic and diluted net loss per common share</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(0.98</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(1.28</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(1.39</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;">$</td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">(1.80</td>
<td style="vertical-align: bottom; white-space: nowrap;">) </td></tr>
<tr style="font-family: Times New Roman; font-size: 10pt; page-break-inside: avoid; background-color: rgb(204, 238, 255);">
<td style="vertical-align: top;"><div style="text-indent: -1em; font-family: "Times New Roman"; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; line-height: normal;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">Basic and diluted weighted average number of common shares outstanding</div></div></td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,364,465</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,368,986</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,415,096</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td>
<td style="vertical-align: bottom; white-space: nowrap;;text-align:right;">15,429,154</td>
<td style="vertical-align: bottom; white-space: nowrap;"> </td></tr></table>
33400000
44688000
53292000
53429000
4605000
5639000
5494000
6126000
38005000
50327000
58786000
59555000
-38005000
-50327000
-58786000
-59555000
1870000
1204000
823000
432000
0
100000
0
0
-36135000
-49023000
-57963000
-59123000
-2.34
-3.18
-3.75
-3.82
15429154
15433348
15448425
15475291
12373000
15594000
19447000
24910000
5746000
7110000
4748000
5044000
18119000
22704000
24195000
29954000
-18119000
-22704000
-24195000
-29954000
3039000
3005000
2766000
2214000
-15080000
-19699000
-21429000
-27740000
-0.98
-1.28
-1.39
-1.80
15364465
15368986
15415096
15429154
<div style="font-family: "Times New Roman"; font-size: 10pt; margin-top: 18pt; margin-bottom: 0pt;"><div style="font-weight:bold;display:inline;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">12. Subsequent Event </div></div></div> <div style="text-indent: 4%; font-family: Times New Roman; font-size: 10pt; margin-top: 6pt; margin-bottom: 0pt;"><div style="font-family: "Times New Roman"; font-size: 10pt; letter-spacing: 0px; top: 0px;;display:inline;">As of February <div style="letter-spacing: 0px; top: 0px;;display:inline;">24</div>, 2021 the company has sold 549,617 shares under the 2020 Sales Agreement (described in Note 6) for an aggregate of approximately $67.8 million in gross proceeds in 2021 to date. Net proceeds to the Company were approximately $66.5 million after deducting commissions and other transaction costs. Approximately $127.3 million remained reserved under the Company’s shelf registration statement and the applicable prospectus supplement for possible future issuance under the 2020 Sales Agreement. </div></div>
549617
67800000
66500000
127300000