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<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(1) Nature of Business</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Synta Pharmaceuticals Corp. (the Company) was incorporated in March 2000 and commenced operations in July 2001. The Company is a biopharmaceutical company focusing on discovering, developing and commercializing small molecule drugs to extend and enhance the lives of patients with severe medical conditions, including cancer and chronic inflammatory diseases.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company is subject to risks common to emerging companies in the drug development and pharmaceutical industry including, but not limited to, uncertainty of product development and commercialization, lack of marketing and sales history, dependence on key personnel, uncertainty of market acceptance of products, product liability, uncertain protection of proprietary technology, potential inability to raise additional financing and compliance with the U.S. Food and Drug Administration and other government regulations.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company has incurred significant operating losses since its inception and, as a result, at December 31, 2012 had an accumulated deficit of $461.2 million. Operations have been funded principally through the sale of common stock and convertible preferred stock, capital leases, non-refundable payments under the former collaboration agreements with GlaxoSmithKline (GSK) and Hoffman-La Roche (Roche), and proceeds from term loans by General Electric Capital Corporation (GECC) and Oxford Finance Corporation (Oxford) (see Note 10). At December 31, 2012, the Company had approximately $100.6 million in cash, cash equivalents and marketable securities.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Based on the Company's current operating levels, it expects its cash resources will be sufficient to fund operations into the second quarter of 2014. This estimate assumes that certain activities contemplated for 2013 will be conducted subject to the availability of sufficient financial resources. The Company expects to continue evaluating additional potential sources of funding, including partnership agreements, cost or risk-sharing agreements, equity financings or other sources.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company may require significant additional funds earlier than it currently expects in order to conduct additional clinical trials and continue to fund its operations. There can be no assurances, however, that additional funding will be available on favorable terms, or at all.</font></p></div>
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<p style="FONT-FAMILY: times"><font size="2"><b>(2) Summary of Significant Accounting Policies</b></font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Principles of Consolidation</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The consolidated financial statements include the financial statements of the Company and its wholly owned subsidiaries. All significant intercompany balances and transactions have been eliminated in consolidation.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Use of Estimates</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect certain reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting periods. Significant items subject to such estimates and assumptions include contract research accruals, recoverability of long-lived assets, measurement of stock-based compensation, and the periods of performance under its collaborative research and development agreements. The Company bases its estimates on historical experience and various other assumptions that management believes to be reasonable under the circumstances. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Cash and Cash Equivalents</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company considers all highly liquid investments with original maturities of three months or less at the date of purchase and an investment in a money market fund to be cash equivalents. Changes in cash and cash equivalents may be affected by shifts in investment portfolio maturities, as well as actual cash disbursements to fund operations.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The primary objective of the Company's investment activities is to preserve its capital for the purpose of funding operations and the Company does not enter into investments for trading or speculative purposes. The Company invests in money market funds and high-grade, short-term commercial paper, which are subject to minimal credit and market risk. The Company's cash is deposited in a highly rated financial institution in the United States. Declines in interest rates, however, would reduce future investment income.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Marketable Securities</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Marketable securities consist of investments in high-grade corporate obligations, and government and government agency obligations that are classified as available-for-sale. Since these securities are available to fund current operations they are classified as current assets on the consolidated balance sheets.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company adjusts the cost of available-for-sale debt securities for amortization of premiums and accretion of discounts to maturity. The Company includes such amortization and accretion in interest and investment income. Realized gains and losses and declines in value, if any, that the Company judges to be other-than-temporary on available-for-sale securities are reported in interest and investment income. To determine whether an other-than-temporary impairment exists, the Company considers whether it intends to sell the debt security and, if the Company does not intend to sell the debt security, it considers available evidence to assess whether it is more likely than not that it will be required to sell the security before the recovery of its amortized cost basis. During the years ended December 31, 2012, 2011 and 2010, the Company determined that no securities were other-than-temporarily impaired.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Marketable securities are stated at fair value, including accrued interest, with their unrealized gains and losses included as a component of accumulated other comprehensive loss, which is a separate component of stockholders' equity. The fair value of these securities is based on quoted prices and observable inputs on a recurring basis. Realized gains and losses are determined on the specific identification method. During the years ended December 31, 2012, 2011 and 2010, the Company recorded no realized gains or losses on marketable securities.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Fair Value of Financial Instruments</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The carrying amounts of the Company's financial instruments, which include cash equivalents, marketable securities, accounts payable and capital lease and term loan obligations, approximate their fair values. The fair value of the Company's financial instruments reflects the amounts that would be received upon sale of an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy has the following three levels:</font></p>
<ul>
<li style="LIST-STYLE-TYPE: none">
<p style="FONT-FAMILY: times"><font size="2">Level 1—quoted prices in active markets for identical assets and liabilities.</font></p>
<p style="FONT-FAMILY: times"><font size="2">Level 2—observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active.</font></p>
<p style="FONT-FAMILY: times"><font size="2">Level 3—unobservable inputs that reflect the Company's own assumptions about the assumptions market participants would use in pricing the asset or liability.</font></p></li></ul>
<p style="FONT-FAMILY: times"><font size="2">        Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company measures the fair value of its marketable securities by taking into consideration valuations obtained from third-party pricing sources. The pricing services utilize industry standard valuation models, including both income and market based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker-dealer quotes on the same or similar securities, issuer credit spreads, benchmark securities and other observable inputs. As of December 31, 2012, the Company's financial assets valued based on Level 1 inputs consisted of cash and cash equivalents in a money market fund and its financial assets valued based on Level 2 inputs consisted of high-grade corporate bonds and commercial paper. During the year ended December 31, 2012, there were no transfers of financials assets between Levels 1 and 2. As of December 31, 2012, the Company had no financial liabilities that were recorded at fair value on the balance sheet. The fair value of the Company's term loan obligations is determined using current applicable rates for similar instruments as of the balance sheet date. The carrying value of the Company's term loan obligations approximates fair value as the Company's interest rate yield is near current market rate yields. The Company's term loan obligations are Level 3 liabilities within the fair value hierarchy.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Property and Equipment</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Property, equipment and software is carried at cost and depreciated using the straight-line method over the estimated useful lives of the related assets, which range from three to five years. Leasehold improvements are amortized over the lesser of the lease term or estimated useful life. Repairs and maintenance costs are expensed as incurred.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Research and Development Costs</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Research and development costs are expensed as incurred. Research and development costs are comprised of costs incurred in performing research and development activities, including internal costs for salaries, benefits, facilities, research-related overhead and stock compensation, and external costs for payments to third party contract research organizations, investigative sites and consultants in connection with the Company's preclinical and clinical programs, costs associated with drug formulation and supply of drugs for clinical trials, and other external costs.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Patents</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Costs to secure and defend patents are expensed as incurred and are classified as general and administrative expense in the Company's consolidated statements of operations. Patent expenses were approximately $1.8 million, $2.3 million, and $1.9 million for the years ended December 31, 2012, 2011 and 2010, respectively.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Income Taxes</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company uses the liability method to account for income taxes. Deferred tax assets and liabilities are determined based on the expected future tax consequences of temporary differences between the Company's consolidated financial statement carrying amounts and the tax basis of assets and liabilities using enacted tax rates expected to be in effect in the years in which the differences are expected to reverse. A valuation allowance is provided to reduce the deferred tax assets to the amount that will more likely than not be realized.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        As of December 31, 2012 and 2011, the Company had no items that were considered to be uncertain tax items or accrued interest or penalties related to uncertain tax positions.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The tax years 2009 through 2012 remain open to examination by the major taxing jurisdictions to which the Company is subject.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Impairment of Long-Lived Assets</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company assesses the potential impairments of its long-lived assets whenever events or changes in circumstances indicate that an asset's carrying value may not be recoverable. If the carrying value exceeds the undiscounted future cash flows estimated to result from the use and eventual disposition of the asset, the Company writes down the asset to its estimated fair value. Management believes that no long-lived assets were impaired as of December 31, 2012 and 2011.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Revenue Recognition</b></font></p>
<ul>
<li style="LIST-STYLE-TYPE: none">
<p style="FONT-FAMILY: times"><font size="2"><b><i>Collaboration and License Agreements</i></b></font></p></li></ul>
<p style="FONT-FAMILY: times"><font size="2">        The Company's principal source of revenue to date has been generated primarily through its former collaborative research and development agreements with Roche and GSK, which included upfront license payments, development milestones, reimbursement of research and development costs, and potential profit sharing payments, commercial and sales-based milestones and royalties. The application of accounting rules requires subjective analysis and requires management to make estimates and assumptions about whether deliverables within multiple-element arrangements are separable from the other aspects of the contractual arrangement into separate units of accounting and to determine the fair value to be allocated to each unit of accounting.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        For multiple-element arrangements entered into or materially modified after January 1, 2011, the Company follows the provisions of ASU No. 2009-13</font> <font size="2"><i>Multiple-deliverable Revenue Arrangements (</i></font><font size="2">ASU No. 2009-13). This standard addresses the determination of the unit(s) of accounting for multiple-element arrangements and how the arrangement's consideration should be allocated to each unit of accounting.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Pursuant to this standard, each required deliverable is evaluated to determine if it qualifies as a separate unit of accounting. For the Company this determination includes an assessment as to whether the deliverable has "stand-alone value" to the customer separate from the undelivered elements. The arrangement's consideration is then allocated to each separate unit of accounting based on the relative selling price of each deliverable. The estimated selling price of each deliverable is determined using the following hierarchy of values: (i) vendor-specific objective evidence of fair value, (ii) third-party evidence of selling price, and (iii) the Company's best estimate of the selling price (BESP). The BESP reflects the Company's best estimate of what the selling price would be if the deliverable was regularly sold by it on a stand-alone basis. The Company expects, in general, to use BESP for allocating consideration to each deliverable in future collaboration agreements. In general, the consideration allocated to each unit of accounting is then recognized as the related goods or services are delivered limited to the consideration not contingent upon future deliverables.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        For multiple-element arrangements entered into prior to January 1, 2011 and not materially modified thereafter, the Company continued to apply its prior accounting policy with respect to such arrangements. Under this policy, in general, revenue from non-refundable, upfront fees related to intellectual property rights/licenses where the Company had continuing involvement was recognized ratably over the estimated period of ongoing involvement because there was no objective and reliable evidence of fair value for certain of the undelivered item to allow the delivered item to be considered a separate unit of accounting. This requirement with respect to the fair value of undelivered items was eliminated in the newly issued accounting standard. In general, the consideration with respect to the other deliverables was recognized when the goods or services were delivered.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company's deliverables under its former collaboration agreement with Roche, including the related rights and obligations, contractual cash flows and performance periods, are more fully described in Note 8. Certain of the deliverables were combined as a single unit of accounting.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The cash flows associated with the single unit of accounting from the research and development portions of the Company's collaborations were recognized as revenue using a time-based model. Under this model, cash flow streams were recognized as revenue over the estimated performance period. Upon achievement of milestones, as defined in the collaboration agreements, revenue was recognized to the extent the accumulated service time, if any, had occurred. The remainder was deferred and recognized as revenue ratably over the remaining estimated performance period. A change in the period of time expected to complete the deliverable was accounted for as a change in estimate on a prospective basis. Revenue was limited to amounts that were non-refundable and that the Company's collaborators were contractually obligated to pay to the Company.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Effective January 1, 2011, the Company adopted ASU No. 2009-13 which codified a method of revenue recognition that has been common practice. Under this method, contingent consideration from research and development activities that is earned upon the achievement of a substantive milestone is recognized in its entirety in the period in which the milestone is achieved. At the inception of each arrangement that includes milestone payments, the Company evaluates whether each milestone is substantive. This evaluation includes an assessment of whether (a) the consideration is commensurate with either (1) the entity's performance to achieve the milestone, or (2) the enhancement of the value of the delivered item(s) as a result of a specific outcome resulting from the entity's performance to achieve the milestone, (b) the consideration relates solely to past performance and (c) the consideration is reasonable relative to all of the deliverables and payment terms within the arrangement. The Company evaluates factors such as the scientific, clinical, regulatory, commercial and other risks that must be overcome to achieve the respective milestone, the level of effort and investment required and whether the milestone consideration is reasonable relative to all deliverables and payment terms in the arrangement in making this assessment. From the effective date of the adoption of this standard, the Company did not achieve any developmental, commercial or sales-based milestones pursuant to its research and collaboration agreement with Roche. Upon the effectiveness of the termination of the collaboration agreement with Roche on February 16, 2012, as more fully described in Note 8, the Company has no ongoing research and collaboration agreements under which milestones may be achieved.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Royalty revenues are based upon a percentage of net sales. Royalties from the sales of products will be recorded on the accrual basis when results are reliably measurable, collectibility is reasonably assured and all other revenue recognition criteria are met. Commercial and sales-based milestones, which are based upon the achievement of certain agreed-upon sales thresholds, will be recognized in the period in which the respective sales threshold is achieved and collectibility is reasonably assured.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b><i>Grant Revenue</i></b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In March 2011, the Company received a grant from the Department of Defense, in the approximate amount of $1 million, for the development of STA-9584 in advanced prostate cancer. The Company conducted work on this study during the one year grant period from April 2011 through March 2012. Reimbursements were based on actual costs agreed upon in the proposal (salary, fringe benefits, overhead, and direct costs such as materials and subcontractors). The Company recognized $147,000 and $853,000 of grant revenue under this grant in the years ended December 31, 2012 and 2011, respectively.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In November 2010, the Company was awarded approximately $1.0 million in grants under the Patient Protection and Affordable Care Act. The Company recognized approximately $1.0 million of grant revenue under these grants in the year ended December 31, 2010.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Stock-Based Compensation</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company recognizes stock-based compensation expense based on the fair value of stock options granted to employees, officers and directors. The Company uses the Black-Scholes option pricing model as it is the most appropriate valuation method for its option grants. The Black-Scholes model requires inputs for risk-free interest rate, dividend yield, volatility and expected lives of the options. Expected volatility was principally based upon the weighted average historical volatility data of the Company's common stock and the historical volatility data from several guideline public biotechnology companies similar in size and value to the Company that also have stock compensation plans with similar terms. The Company estimates the forfeiture rate based on historical data. Based on an analysis of historical forfeitures, the Company has applied a forfeiture rate of 10% to all options that vest upon completion of the first year of service following the date of grant. The analysis is re-evaluated at least annually and the forfeiture rate is adjusted as necessary. The risk-free rate for periods within the expected life of the option is based on the U.S. Treasury yield curve in effect at the time of the grant. The expected lives for options granted represent the period of time that options granted are expected to be outstanding. The Company uses the simplified method for determining the expected lives of options.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        For awards with graded vesting, the Company allocates compensation costs on a straight-line basis over the requisite service period. The Company amortizes the fair value of each option over each option's service period, which is generally the vesting period.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Certain of the employee stock options granted by the Company are structured to qualify as incentive stock options (ISOs). Under current tax regulations, the Company does not receive a tax deduction for the issuance, exercise or disposition of ISOs if the employee meets certain holding requirements. If the employee does not meet the holding requirements, a disqualifying disposition occurs, at which time the Company may receive a tax deduction. The Company does not record tax benefits related to ISOs unless and until a disqualifying disposition is reported. In the event of a disqualifying disposition, the entire tax benefit is recorded as a reduction of income tax expense. The Company has not recognized any income tax benefit for the share-based compensation arrangement due to the fact that the Company does not believe it is more likely than not it will recognize any deferred tax assets from such compensation cost recognized in the current period.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Comprehensive Loss</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Comprehensive loss is defined as the change in equity of a business enterprise during a period from transactions, and other events and circumstances from non-owner sources. Changes in unrealized gains and losses on marketable securities represent the only difference between the Company's net loss and comprehensive loss.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In the first quarter of 2012, the Company adopted ASU No. 2011-05,</font> <font size="2"><i>Comprehensive Income (Topic 220): Presentation of Comprehensive Income</i></font> <font size="2">(ASU No. 2011-05). ASU No. 2011-05 requires companies to present the components of net income and other comprehensive income either as one continuous statement or as two consecutive statements, eliminating the option to present components of other comprehensive income as part of the statement of changes in stockholders' equity. This update does not change the items which must be reported in other comprehensive income, how such items are measured or when they must be reclassified to net income. Upon adoption, the Company elected to present comprehensive income in two separate but consecutive statements as part of the consolidated financial statements included in this Annual Report on Form 10-K.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Segment Reporting</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Operating segments are determined based on the way management organizes its business for making operating decisions and assessing performance. The Company has only one operating segment, the discovery, development and commercialization of drug products.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Basic and Diluted Loss Per Common Share</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Basic net loss per share is computed using the weighted average number of common shares outstanding during the period, excluding restricted stock that has been issued but is not yet vested. Diluted net loss per common share is computed using the weighted average number of common shares outstanding and the weighted average dilutive potential common shares outstanding using the treasury stock method. However, for the years ended December 31, 2012, 2011 and 2010, diluted net loss per share is the same as basic net loss per share as the inclusion of weighted average shares of unvested restricted common stock and common stock issuable upon the exercise of stock options would be anti-dilutive.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The following table summarizes outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive:</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="55"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="55"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="55"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Years Ended December 31,</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Common stock options</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,521,584</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,821,073</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,326,979</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Unvested restricted stock</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35,122</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">82,450</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">140,613</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(3) Cash, Cash Equivalents and Marketable Securities</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        A summary of cash, cash equivalents and available-for-sale marketable securities held by the Company as of December 31, 2012 and 2011 was as follows (see Note 2):</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>December 31, 2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Cost</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Unrealized<br />
gains</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Unrealized<br />
losses</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Fair<br />
value</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cash and cash equivalents:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cash and money market funds (Level 1)</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">81,512</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">81,512</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Marketable securities:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Corporate debt securities due within 1 year of date of purchase (Level 2)</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">19,085</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(1</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">19,087</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total cash, cash equivalents and marketable securities</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">100,597</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(1</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">100,599</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2"> <br /></font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="45"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="45"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>December 31, 2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Cost</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Unrealized<br />
gains</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Unrealized<br />
losses</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Fair<br />
value</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cash and cash equivalents:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cash and money market funds (Level 1)</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">25,326</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">25,326</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Government-sponsored entities and corporate debt securities due within 3 months of date of purchase (Level 2)</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">4,749</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">4,749</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total cash and cash equivalents</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">30,075</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">30,075</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Marketable securities:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Corporate debt securities due within 1 year of date of purchase (Level 2)</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">9,647</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">9,650</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total cash, cash equivalents and marketable securities</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">39,722</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">39,725</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(4) Property and Equipment</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Property and equipment consist of the following:</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="64"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="64"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Laboratory equipment</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,531</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,468</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Leasehold improvements</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,939</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,847</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Computers and software</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,630</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,315</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Furniture and fixtures</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,170</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,135</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">21,270</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">20,765</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less accumulated depreciation and amortization</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(20,096</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(19,358</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,174</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,407</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2">        Depreciation and amortization expenses of property and equipment, including equipment purchased under capital leases, were approximately $0.7 million, $1.5 million and $1.9 million for the years ended December 31, 2012, 2011 and 2010, respectively.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The net book value and accumulated amortization of equipment under capital lease was approximately $1,000 and $57,000, respectively, at December 31, 2012, and $16,000 and $43,000, respectively, at December 31, 2011.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(5) Stockholders' Equity</b></font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Common Stock</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Each common stockholder is entitled to one vote for each share of stock held. The common stock will vote together with all other classes and series of stock of the Company as a single class on all actions to be taken by the Company's stockholders. Each share of common stock is entitled to receive dividends, as and when declared by the Company's board of directors.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company has never declared cash dividends on its common stock and does not expect to do so in the foreseeable future.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Registered Direct Offering</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In December 2012, the Company entered into common stock purchase agreements with investors and certain directors, including its largest stockholder, pursuant to which the Company sold 7,000,000 shares of its common stock in a registered direct offering at a purchase price of $8.60 per share. These shares were sold directly to these investors and directors without a placement agent, underwriter, broker or dealer. The net proceeds to the Company were approximately $59.8 million after deducting estimated offering expenses payable by the Company.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Registered Direct Offering</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In July 2012, the Company entered into subscription agreements with certain directors, including its largest stockholder, pursuant to which the Company sold 3,976,702 shares of its common stock in a registered direct offering at a purchase price of $6.49 per share. These shares were sold directly to these directors without a placement agent, underwriter, broker or dealer. The net proceeds to the Company were approximately $25.8 million after deducting estimated offering expenses payable by the Company.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Public Offering</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In January 2012 and February 2012, the Company raised approximately $35.4 million in gross proceeds from the sale of an aggregate 8,050,000 shares of its common stock in a public offering at $4.40 per share, including 7,000,000 shares in the initial closing in January 2012 and 1,050,000 shares in a second closing in February 2012 upon the full exercise of the over-allotment option granted to the underwriters. One of the Company's directors, who is its largest stockholder, purchased 1,136,363 shares in this offering. The net offering proceeds to the Company were approximately $33.0 million after deducting underwriters' discounts, fees and commissions, and other offering expenses payable by the Company.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Equity Line of Credit</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In October 2010, as amended, the Company entered into a common stock purchase agreement (Purchase Agreement) with Azimuth Opportunity Ltd. (Azimuth) pursuant to which the Company obtained an equity line of credit facility (Facility) under which it may have sold, in its sole discretion, and Azimuth was committed to purchase, subject to the terms and conditions set forth in the Purchase Agreement, up to $35 million or 8,106,329 shares of the Company's common stock, whichever was fewer, over the term of the agreement which expired on May 1, 2012. No shares were sold to Azimuth under the Facility.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>At-The-Market Issuance Sales Agreement</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        On May 2, 2012, the Company entered into an at-the-market issuance sales agreement, as amended, (Sales Agreement) with MLV & Co. LLC (MLV), pursuant to which the Company may issue and sell shares of its common stock having an aggregate offering price of up to $28 million from time to time, at the Company's option, through MLV as its sales agent. Sales of common stock through MLV, if any, will be made by any method that is deemed an "at-the-market" offering as defined in Rule 415 promulgated under the Securities Act of 1933, as amended, including by means of ordinary brokers' transactions at market prices, in block transactions or as otherwise agreed by the Company and MLV. Subject to the terms and conditions of the Sales Agreement, MLV will use commercially reasonable efforts to sell the common stock based upon the Company's instructions (including any price, time or size limits or other customary parameters or conditions the Company may impose). The Company is not obligated to make any sales of its common stock under the Sales Agreement. Any shares sold will be sold pursuant to the Company's effective shelf registration statement on Form S-3. The Company will pay MLV a commission of up to 3% of the gross proceeds. The Sales Agreement will terminate upon the earlier of the sale of all common stock subject to the Sales Agreement or termination of the Sales Agreement by the Company or MLV. To date, no shares have been sold under the Sales Agreement.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Issuer-Directed Registered Direct Offering</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In April 2011, the Company raised approximately $35.2 million in gross proceeds from the sale of an aggregate of 7,191,731 shares of its common stock at a purchase price of $4.89 per share, which was the closing price of the Company's common stock on the date of sale, in an issuer-directed registered direct offering. The shares were sold directly to investors without a placement agent, underwriter, broker or dealer, and no warrants were issued as part of this transaction. 1,581,493 shares were sold to certain of the Company's directors and entities affiliated with these directors, and the remainder of the shares were sold to institutional investors. The proceeds to the Company were approximately $34.8 million after deducting estimated offering expenses payable by the Company.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(6) Stock-Based Compensation</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company's 2006 Stock Plan provides for the grant of incentive stock options, nonstatutory stock options and non-vested stock to employees, officers, directors and consultants to the Company. In January 2013, the number of shares of common stock reserved for issuance under the 2006 Stock Plan was increased from 7,700,000 to 9,000,000 pursuant to an "evergreen" provision, which provides for an annual increase based on the lesser of 1,300,000 shares, 5% of the Company's then outstanding shares of common stock, or such other amount as the board of directors may determine. This increase was approved by the board of directors in December 2012. The administration of the 2006 Stock Plan is under the general supervision of the compensation committee of the board of directors. The exercise price of the stock options is determined by the compensation committee of the board of directors, provided that incentive stock options are granted at not less than fair market value of the common stock on the date of grant and expire no later than ten years from the date the option is granted. Options generally vest over four years. As of December 31, 2012, the Company had options outstanding to purchase 5,521,584 shares of its common stock, which includes options outstanding under its 2001 Stock Plan that was terminated in March 2006, and had 35,122 restricted shares of common stock outstanding. As of December 31, 2012, 1,902,341 shares were available for future issuance and were subsequently increased by an additional 1,300,000 shares in January 2013 related to the "evergreen" provision.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The following table summarizes stock option activity during the year ended December 31, 2012:</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="59"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="44"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="54"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Shares</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br />
average<br />
exercise<br />
price</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br />
average<br />
remaining<br />
contractual<br />
life (years)</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Aggregate<br />
intrinsic<br />
value</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at January 1</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,821,073</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7.54</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Options granted</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,799,096</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5.14</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Options exercised</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(322,298</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3.54</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Options cancelled</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,776,287</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">9.36</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at December 31</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,521,584</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.40</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.83</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">17,472,889</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Exercisable at December 31</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,091,173</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7.44</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5.25</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,906,822</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2">        The aggregate intrinsic value of all options outstanding and exercisable represents the total pre-tax amount, net of the exercise price, which would have been received by option holders if all option holders had exercised all options with an exercise price lower than the closing stock price of $9.02 on December 31, 2012, which was the last trading day of the year. The total intrinsic value of options exercised during the years ended December 31, 2012, 2011 and 2010 was approximately $904,000, $518,000 and $278,000, respectively. The total cash received by the Company as a result of stock option exercises during 2012, 2011 and 2010 was $1.1 million, $0.5 million and $0.3 million, respectively. The weighted-average grant date fair values of options granted during the years ended December 31, 2012, 2011 and 2010 were $4.10, $4.26 and $3.27, respectively.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Non-Vested ("Restricted") Stock Awards With Service Conditions</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company's share-based compensation plan provides for awards of restricted shares of common stock to employees, officers, directors and consultants to the Company. Restricted stock awards are subject to forfeiture if employment or service terminates during the prescribed retention period. Restricted shares vest over the service period. The total fair value of restricted stock that vested during 2012, 2011 and 2010 was $0.6 million, $0.6 million and $0.2 million, respectively.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The following table summarizes unvested restricted shares during the year ended December 31, 2012:</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="44"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="50"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Shares</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br />
average<br />
grant date<br />
fair value</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at January 1</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">82,450</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4.94</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Vested</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(92,571</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5.16</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Granted</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">45,243</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5.47</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at December 31</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35,122</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5.04</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2"><b>Stock-Based Compensation Expense</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        For the years ended December 31, 2012, 2011 and 2010, the fair value of each employee stock option award was estimated on the date of grant based on the fair value method using the Black-Scholes option pricing valuation model with the following weighted average assumptions:</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="15"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="58"></td>
<td style="FONT-FAMILY: times" width="15"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="58"></td>
<td style="FONT-FAMILY: times" width="15"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="58"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Years ended December 31,</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Risk-free interest rate</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1.11</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2.48</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2.62</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expected life in years</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.25 years</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.25 years</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.25 years</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Volatility</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">101</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">101</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">102</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expected dividend yield</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2">        Stock-based compensation expense during the years ended December 31, 2012, 2011 and 2010 was as follows (in thousands):</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="39"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="39"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="39"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Years ended December 31,</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Stock-based compensation expense by type of award:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Employee stock options</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,082</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,951</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,614</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Restricted stock</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">240</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">403</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">434</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total stock-based compensation expense</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,322</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,354</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">4,048</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Effect of stock-based compensation expense by line item:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Research and development</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,485</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,494</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,074</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">General and administrative</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">837</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">860</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">974</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total stock-based compensation expense included in net loss</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,322</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,354</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">4,048</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2">        Unrecognized stock-based compensation expense as of December 31, 2012 was as follows (in thousands):</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="64"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="49"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Unrecognized<br />
stock<br />
compensation<br />
expense as of<br />
December 31,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br />
average<br />
remaining<br />
period<br />
(in years)</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Employee stock options</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,747</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2.65</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Restricted stock</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">172</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.62</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,919</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2.61</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>7) Other Accrued Liabilities</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Other accrued liabilities consist of the following:</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="64"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="64"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Compensation and benefits</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,272</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,914</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Professional fees</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">999</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,069</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Other</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">856</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">611</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,127</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,594</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(8) License and Development Agreements</b></font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Roche</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In December 2008, as amended in February 2010, February 2011 and July 2011, the Company and Roche entered into a collaborative license agreement (the Roche Agreement) to discover, develop, and commercialize small-molecule drugs targeting calcium release-activated calcium modulator (CRACM) channels. The goal of this alliance was to develop a novel category of oral, disease-modifying agents for the treatment of rheumatoid arthritis and other autoimmune diseases and inflammatory conditions. The Roche Agreement consisted of the following funding streams: an upfront license payment, reimbursements of certain research and development costs, product development milestones, sales milestones and product royalty payments.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Pursuant to the Roche Agreement, the Company received a non-refundable upfront license payment of $16 million in January 2009. Roche reimbursed all of the Company's research and certain early development costs over the two year research term that concluded on December 31, 2010. The Company received approximately $21.2 million in research and development support under the Roche Agreement.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Roche terminated the Roche Agreement effective February 16, 2012. All rights to certain products, referred to as Licensed Compounds, which were identified and studied prior to the end of the two year research term, reverted to the Company upon the effectiveness of the termination. The Company may pay Roche a low single-digit royalty on any potential future sales of licensed products. The Company did not incur any termination costs or penalties as a result of the termination of the Roche Agreement. No development milestones were achieved under the Roche Agreement.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The $16 million non-refundable upfront license payment was being recognized ratably using the time-based model over the estimated performance period through June 2012. In the fourth quarter of 2011, upon notification of Roche's election to terminate the Roche Agreement, the Company accelerated the recognition of approximately $2.1 million of remaining deferred revenue from the upfront payment because the Company had no remaining substantial performance obligations. In the years ended December 31, 2012, 2011 and 2010, the Company recognized $0, $6.7 million and $4.6 million, respectively, of license revenue under the Roche Agreement. Reimbursements of research and development costs to the Company by Roche were recorded as cost sharing revenue in the period in which the related research and development costs were incurred. In the years ended December 31, 2012, 2011 and 2010, the Company recognized $0, $0 and $9.3 million, respectively, of cost sharing revenue under the Roche Agreement.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Co-Development Agreement</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In July 2011, the Company entered into a co-development agreement with a clinical research organization (CRO) for the conduct of certain company-sponsored clinical trials. Under the co-development agreement, this CRO is performing clinical research services under a reduced fee structure in exchange for a share of licensing payments and commercial revenues, if any, resulting from the product under development up to a specified maximum payment, which is defined as a multiple of the fee reduction realized.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(9) Income Taxes</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Differences between the actual tax provision (benefit) and the tax provision (benefit) computed using the United States federal income tax rate is as follows:</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="50"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="50"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="50"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Years ended December 31,</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Provision (benefit) at statutory rate</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(21,349</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(16,109</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(12,739</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">State taxes, net of federal benefit</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(3,220</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(2,379</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,967</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">State tax rate change</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">84</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">196</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">State net operating loss expiration</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,167</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,867</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,820</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Stock-based compensation</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">382</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">373</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">791</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Tax credits</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(411</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,537</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,686</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Other</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">22</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">259</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(78</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">(Decrease) increase in valuation allowance</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">21,409</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">16,442</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,663</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Income tax provision (benefit)</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2">        The effects of temporary differences that give rise to significant portions of deferred tax assets and deferred tax liabilities at December 31 are presented below:</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="56"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="56"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Deferred tax assets:</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Federal and state net operating loss carryforwards</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">143,988</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">123,463</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Federal and state research and experimentation credits</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">17,225</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">16,796</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Depreciation and amortization</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,594</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,776</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Deferred compensation</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,368</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,077</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Other</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,014</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">667</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Deferred tax assets</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">170,189</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">148,779</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less valuation allowance</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(170,189</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(148,779</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net deferred tax assets</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2">        The total valuation allowance increased by approximately $21.4 million, $16.4 million and $11.7 million in the years ended December 31, 2012, 2011 and 2010, respectively.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company has established valuation allowances against its deferred tax assets because management believes that, after considering all of the available objective evidence, both historical and prospective, the realization of the deferred tax assets does not meet the "more likely than not" criteria. The Company evaluates the need for a valuation allowance on a quarterly basis.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        For tax years through 2012 the Company performed analyses to determine if there were changes in ownership, as defined by Section 382 of the Internal Revenue Code that would limit its ability to utilize certain net operating loss and tax credit carryforwards. The Company determined that it experienced an ownership change, as defined by Section 382, in connection with its acquisition of Principia Associates, Inc. on September 20, 2002, but did not experience a change in ownership upon the effectiveness of the Company's IPO, or any other equity offerings to date. As a result, the utilization of the Company's federal tax net operating loss carryforwards generated prior to the ownership change is limited. As of December 31, 2012, the Company has net operating loss carryforwards for U.S. federal tax purposes of approximately $400.2 million, after excluding net operating losses that have expired unused as a result of Section 382 limitations, with the remainder expiring in varying amounts through 2032 unless utilized. At December 31, 2012, the Company has state net operating loss carryforwards of approximately $157.8 million, which will expire through 2032 unless utilized. The net operating loss carryforwards include approximately $1.1 million of deductions related to the exercise of common stock options. This amount represents an excess tax benefit and has not been included in the gross deferred tax asset reflected for net operating losses.The utilization of these net operating loss carryforwards may be further limited if the Company experiences future ownership changes as defined in Section 382 of the Internal Revenue Code. Approximately $60.0 million of state net operating loss carryforwards expired in 2012.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        At December 31, 2012, the Company had approximately $13.2 million and $6.1 million, respectively, in federal and state research and development credits which expire through 2031 and 2027, respectively.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company is currently open to examination under the statute of limitations by the Internal Revenue Service and state jurisdictions for the tax years ended 2009 through 2012. Carryforward tax attributes generated in years past may still be adjusted upon future examination if they have or will be used in a future period. The Company is currently not under examination by the Internal Revenue Service or any other jurisdictions for any tax years.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company does not consider any of its tax positions to be uncertain and accordingly there are no tax reserves for the years ended December 31, 2012, 2011, and 2010. The Company will recognize interest expense and penalties related to uncertain tax positions in income tax expense. The Company has not, as yet, conducted a study of its domestic research and development credit carryforwards. This study may result in an increase or decrease to the Company's research and development credit carryforwards; however, until a study is completed and any adjustment is known, no amounts are being presented as an uncertain tax position. A full valuation allowance has been provided against the Company's research and development credits, and if an adjustment is required, this adjustment would be offset by an adjustment to the valuation allowance. As a result, there would be no impact to the consolidated balance sheet, statement of operations and comprehensive loss or cash flows if an adjustment were required.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(10) Commitments and Contingencies</b></font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Leases</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company leases its research and office facilities under three non-cancelable and renewable operating leases with terms expiring in the fourth quarter of 2016. These lease agreements include customary provisions for rent increases, escalations for operating costs and renewals. The Company also leases equipment under various other non-cancellable operating leases.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Term Loans</b></font></p>
<p style="FONT-FAMILY: times"><font size="2"><b><i>General Electric Capital Corporation</i></b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In September 2010, the Company entered into a $15 million loan and security agreement, as amended, with GECC and one other lender, all of which was funded at the closing in September 2010 (the GECC Term Loan). Interest on the borrowings under the GECC Term Loan accrues at an annual rate of 9.75%.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company made interest-only payments through June 2012. Beginning in July 2012, the Company began making 25 equal monthly payments of principal plus accrued interest on the outstanding balance. In addition to the interest payable under the GECC Term Loan, the Company paid origination and amendment fees in the amount of $388,000 and is obligated to pay an exit fee of $525,000 at the time of the final payment of the outstanding principal.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Origination and exit fees are being amortized and accreted, respectively, to interest expense over the term of the GECC Term Loan. As of December 31, 2012, the Company had paid approximately $262,000 of legal fees and expenses in connection with the GECC Term Loan. These expenses have been deferred and, together with the origination fees, are included in other assets, and will be expensed over the term of the GECC Term Loan. In the years ended December 31, 2012, 2011 and 2010, the Company recognized approximately $321,000, $275,000 and $67,000, respectively, in interest expense in connection with these origination, exit and transaction fees and expenses. In the years ended December 31, 2012, 2011 and 2010, respectively, the Company recognized approximately $1.4 million, $1.5 million and $453,000, respectively, in interest expense related to the outstanding principal under the GECC Term Loan. No warrants were issued in connection with the GECC Term Loan. The Company may prepay the full amount of the GECC Term Loan, subject to prepayment premiums under certain circumstances.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The GECC Term Loan is secured by substantially all of the Company's assets, except its intellectual property. The Company has granted GECC a springing security interest in its intellectual property in the event the Company is not in compliance with certain cash usage covenants, as defined therein. The GECC Term Loan contains restrictive covenants, including the requirement for the Company to receive the prior written consent of GECC to enter into loans, other than up to $4.0 million of equipment financing, restrictions on the declaration or payment of dividends, restrictions on acquisitions, and customary default provisions that include material adverse events, as defined therein. The Company has determined that the risk of subjective acceleration under the material adverse events clause is remote and therefore has classified the outstanding principal in current and long-term liabilities based on the timing of scheduled principal payments. In addition, at the time of the closing of the GECC Term Loan, the Company repaid approximately $787,000 of remaining principal outstanding under its existing equipment leases with GECC.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b><i>Oxford Finance Corporation</i></b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In March 2011, the Company entered into a $2 million loan and security agreement with Oxford, all of which was funded in March 2011 (the Oxford Term Loan). Interest on the borrowings under the Oxford Term Loan accrues at an annual rate of 13.35%. Beginning in May 2011, the Company began making 36 equal monthly payments of principal plus accrued interest on the outstanding balance. In December 2012, the Company entered into a loan modification agreement under which the Company may draw down up to an additional $0.6 million in equipment financing until May 31, 2013 that would be payable in 36 equal monthly payments of principal plus accrued interest on the outstanding balance. As of December 31, 2012, no additional equipment financing had been used. The Company recognized approximately $172,000 and $192,000 in the years ended December 31, 2012 and 2011, respectively, in interest expense related to the outstanding principal under the Oxford Term Loan. In addition to the interest payable under the Oxford Term Loan, the Company paid approximately $88,000 of administrative and legal fees and expenses in connection with the Oxford Term Loan. These expenses have been deferred, are included in other assets and are being expensed over the term of the Oxford Term Loan. No warrants were issued in connection with the Oxford Term Loan. The Company may prepay the full amount of the Oxford Term Loan, subject to prepayment premiums under certain circumstances. Oxford has the right to require the Company to prepay the full amount of the Oxford Term Loan if the Company prepays the full amount of the GECC Term Loan under certain circumstances.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Oxford Term Loan is secured by certain laboratory and office equipment, furniture and fixtures acquired through September 30, 2010. In connection with the Oxford Term Loan, Oxford and GECC entered into a Lien Subordination Agreement, whereby GECC granted Oxford a first priority perfected security interest in the loan collateral. The Oxford Term Loan contains restrictive covenants, including the requirement for the Company to receive the prior written consent of Oxford to enter into acquisitions in which the Company incurs more than $2.0 million of related indebtedness, and customary default provisions that include material adverse events, as defined therein. The Company has determined that the risk of subjective acceleration under the material adverse events clause is remote and therefore has classified the outstanding principal in current and long-term liabilities based on the timing of scheduled principal payments.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Future minimum payments, excluding operating costs and taxes, under the Company's capital and non-cancellable operating leases and term loans are approximately as follows (in thousands):</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="49"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="53"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="53"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="36"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Operating<br />
leases</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>GECC<br />
Term Loan</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Oxford<br />
Term Loan</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Capital<br />
leases</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Years ending December 31,</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2013</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,162</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,996</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">813</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">13</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2014</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,160</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,863</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">271</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2015</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,196</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2016</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,965</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total minimum payments</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">8,483</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,859</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,084</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less: amount representing interest</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,459</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(96</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(0</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Present value of minimum payments</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,400</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">988</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less current portions of obligations</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(7,200</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(724</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(13</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Long term obligation</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,200</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">264</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2">        Rent expense under operating leases was approximately $2.2 million, $1.9 million and $2.0 million, for the years ended December 31, 2012, 2011 and 2010, respectively.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b>Guarantees</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        As permitted under Delaware law, the Company's Certificate of Incorporation and Bylaws provide that the Company will indemnify certain of its officers and directors for certain claims asserted against them in connection with their service as an officer or director. The maximum potential amount of future payments that the Company could be required to make under these indemnification provisions is unlimited. However, the Company has purchased a directors' and officers' liability insurance policy that reduces its monetary exposure and enables it to recover a portion of any future amounts paid. The Company believes the estimated fair value of these indemnification arrangements is minimal.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company customarily agrees in the ordinary course of its business to indemnification provisions in agreements with clinical trial investigators in its drug development programs, in sponsored research agreements with academic and not-for-profit institutions, in various comparable agreements involving parties performing services for the Company in the ordinary course of business, and in its real estate leases. The Company expects to agree to certain indemnification provisions in drug discovery and development collaboration agreements the Company may enter into. With respect to the Company's clinical trials and sponsored research agreements, these indemnification provisions typically apply to any claim asserted against the investigator or the investigator's institution relating to personal injury or property damage, violations of law or certain breaches of the Company's contractual obligations arising out of the research or clinical testing of the Company's compounds or drug candidates. With respect to lease agreements, the indemnification provisions typically apply to claims asserted against the landlord relating to personal injury or property damage caused by the Company, to violations of law by the Company or to certain breaches of the Company's contractual obligations. The indemnification provisions appearing in collaboration agreements are similar, but in addition provide some limited indemnification for the collaborator in the event of third-party claims alleging infringement of intellectual property rights. In each of the cases above, the term of these indemnification provisions generally survives the termination of the agreement, although the provision has the most relevance during the contract term and for a short period of time thereafter. The maximum potential amount of future payments that the Company could be required to make under these provisions is generally unlimited. The Company purchases insurance policies covering personal injury, property damage and general liability that reduce its exposure for indemnification and would enable it in many cases to recover a portion of any future amounts paid. The Company has never paid any material amounts to defend lawsuits or settle claims related to these indemnification provisions. Accordingly, the Company believes the estimated fair value of these indemnification arrangements is minimal.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(11) Related Party Transactions</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company paid its scientific founder and a member of the board of directors consulting fees of $120,000 in each of the years ended in December 31, 2011 and 2010.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In April 2011, the Company sold an aggregate of 1,581,493 shares of common stock to certain of the Company's directors and entities affiliated with these directors at a purchase price of $4.89 per share in an issuer-directed registered direct offering (see Note 5).</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In January 2012, the Company sold 1,136,363 shares of common stock to a director, who is its largest stockholder, at a purchase price of $4.40 per share in a public offering (see Note 5).</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In July 2012, the Company entered into subscription agreements with certain directors, including its largest stockholder, pursuant to which the Company sold 3,976,702 shares of its common stock in a registered direct offering at a purchase price of $6.49 per share (see Note 5).</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In November 2012, the Company purchased and retired 3,969 shares from an officer upon the vesting of restricted common stock in order to fund the related tax liability.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In December 2012, the Company entered into common stock purchase agreements with certain directors, including its largest stockholder, pursuant to which the Company sold 2,649,535 shares of its common stock in a registered direct offering at a purchase price of $8.60 per share (see Note 5).</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In January 2013, a director exercised an aggregate of 114,250 shares of common stock options that resulted in $1.0 million in proceeds to the Company.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(12) Retirement Plan</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In 2003, the Company implemented a 401(k) retirement plan (the Synta 401(k) Plan) in which substantially all of its permanent employees are eligible to participate. Participants may contribute a percentage of their annual compensation to the plan, subject to statutory limitations. The Company may declare discretionary matching contributions to the Synta 401(k) Plan.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In April 2006, the Company began matching participants' contributions up to 50% of the first 6% of the employee's salary. The match is subject to a three-year equally graded vesting schedule and any forfeitures will be applied to reduce the Company's contributions. Company contributions for the years ended December 31, 2012, 2011 and 2010 were approximately $376,000, $372,000 and $429,000, respectively, subject to forfeitures.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>(13) Quarterly Financial Data (unaudited)</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The following tables present a summary of quarterly results of operations for 2012 and 2011:</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>Three Months Ended</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>March 31,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>June 30,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>September 30,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>(in thousands, except shares and per share data)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Revenues:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">License and milestone revenue</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cost sharing reimbursements, net</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total collaboration revenues</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Grant revenue</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">147</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total revenues</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">147</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Operating expenses:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Research and development</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">12,066</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">11,252</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">11,743</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">14,351</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">General and administrative</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,646</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,882</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,796</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,352</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total operating expenses</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">14,712</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">14,134</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">14,539</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">17,703</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Loss from operations</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(14,565</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(14,134</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(14,539</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(17,703</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Interest expense, net</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(486</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(486</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(457</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(420</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net loss</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(15,051</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(14,620</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(14,996</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(18,123</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Basic and diluted net loss per common share</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.27</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.25</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.25</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.29</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Basic and diluted weighted average number of common shares outstanding</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">56,366,992</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">57,650,412</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">60,661,720</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">62,914,546</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2"> <br /></font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>Three Months Ended</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>March 31,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>June 30,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>September 30,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>(in thousands, except shares and per share data)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Revenues:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">License and milestone revenue</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,302</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cost sharing reimbursements, net</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total collaboration revenues</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,302</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Grant revenue</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">211</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">521</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">121</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total revenues</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,354</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,664</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,423</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Operating expenses:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Research and development</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">9,436</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">10,417</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">10,751</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">10,859</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">General and administrative</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,673</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,946</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,131</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,803</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total operating expenses</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">12,109</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">13,363</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">13,882</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">13,662</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Loss from operations</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(10,966</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(12,009</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(12,218</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(10,239</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Interest expense, net</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(435</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(493</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(516</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(504</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net loss</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(11,401</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(12,502</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(12,734</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(10,743</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Basic and diluted net loss per common share</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.27</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.26</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.26</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.22</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Basic and diluted weighted average number of common shares outstanding</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">42,008,818</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">47,845,315</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">49,403,589</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">49,426,806</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2">Future minimum payments, excluding operating costs and taxes, under the Company's capital and non-cancellable operating leases and term loans are approximately as follows (in thousands):</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="49"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="53"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="53"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="36"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Operating<br />
leases</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>GECC<br />
Term Loan</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Oxford<br />
Term Loan</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Capital<br />
leases</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Years ending December 31,</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2013</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,162</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,996</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">813</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">13</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2014</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,160</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,863</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">271</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2015</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,196</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2016</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,965</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total minimum payments</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">8,483</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,859</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,084</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less: amount representing interest</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,459</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(96</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(0</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Present value of minimum payments</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,400</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">988</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less current portions of obligations</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(7,200</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(724</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(13</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Long term obligation</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,200</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">264</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
15000000
0.0975
25
388000
525000
262000
275000
67000
1500000
453000
201000
4000000
0.1335
36
192000
88000
2162000
2160000
2196000
1965000
8483000
7996000
4863000
12859000
11400000
7200000
4200000
813000
271000
1084000
988000
724000
264000
13000
1000
14000
0
14000
1900000
2000000
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 84.82%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 205px">
<p style="FONT-FAMILY: times"> </p>
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="64"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="64"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Compensation and benefits</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,272</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,914</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Professional fees</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">999</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,069</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Other</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">856</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">611</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,127</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,594</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
3272000
2914000
999000
1069000
2200000
2000000
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Principles of Consolidation</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The consolidated financial statements include the financial statements of the Company and its wholly owned subsidiaries. All significant intercompany balances and transactions have been eliminated in consolidation.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Use of Estimates</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect certain reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting periods. Significant items subject to such estimates and assumptions include contract research accruals, recoverability of long-lived assets, measurement of stock-based compensation, and the periods of performance under its collaborative research and development agreements. The Company bases its estimates on historical experience and various other assumptions that management believes to be reasonable under the circumstances. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Cash and Cash Equivalents</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company considers all highly liquid investments with original maturities of three months or less at the date of purchase and an investment in a money market fund to be cash equivalents. Changes in cash and cash equivalents may be affected by shifts in investment portfolio maturities, as well as actual cash disbursements to fund operations.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The primary objective of the Company's investment activities is to preserve its capital for the purpose of funding operations and the Company does not enter into investments for trading or speculative purposes. The Company invests in money market funds and high-grade, short-term commercial paper, which are subject to minimal credit and market risk. The Company's cash is deposited in a highly rated financial institution in the United States. Declines in interest rates, however, would reduce future investment income.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Marketable Securities</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Marketable securities consist of investments in high-grade corporate obligations, and government and government agency obligations that are classified as available-for-sale. Since these securities are available to fund current operations they are classified as current assets on the consolidated balance sheets.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company adjusts the cost of available-for-sale debt securities for amortization of premiums and accretion of discounts to maturity. The Company includes such amortization and accretion in interest and investment income. Realized gains and losses and declines in value, if any, that the Company judges to be other-than-temporary on available-for-sale securities are reported in interest and investment income. To determine whether an other-than-temporary impairment exists, the Company considers whether it intends to sell the debt security and, if the Company does not intend to sell the debt security, it considers available evidence to assess whether it is more likely than not that it will be required to sell the security before the recovery of its amortized cost basis. During the years ended December 31, 2012, 2011 and 2010, the Company determined that no securities were other-than-temporarily impaired.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Marketable securities are stated at fair value, including accrued interest, with their unrealized gains and losses included as a component of accumulated other comprehensive loss, which is a separate component of stockholders' equity. The fair value of these securities is based on quoted prices and observable inputs on a recurring basis. Realized gains and losses are determined on the specific identification method. During the years ended December 31, 2012, 2011 and 2010, the Company recorded no realized gains or losses on marketable securities.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Fair Value of Financial Instruments</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The carrying amounts of the Company's financial instruments, which include cash equivalents, marketable securities, accounts payable and capital lease and term loan obligations, approximate their fair values. The fair value of the Company's financial instruments reflects the amounts that would be received upon sale of an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy has the following three levels:</font></p>
<ul>
<li style="list-style: none">
<p style="FONT-FAMILY: times"><font size="2">Level 1—quoted prices in active markets for identical assets and liabilities.</font></p>
<p style="FONT-FAMILY: times"><font size="2">Level 2—observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active.</font></p>
<p style="FONT-FAMILY: times"><font size="2">Level 3—unobservable inputs that reflect the Company's own assumptions about the assumptions market participants would use in pricing the asset or liability.</font></p></li></ul>
<p style="FONT-FAMILY: times"><font size="2">        Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company measures the fair value of its marketable securities by taking into consideration valuations obtained from third-party pricing sources. The pricing services utilize industry standard valuation models, including both income and market based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker-dealer quotes on the same or similar securities, issuer credit spreads, benchmark securities and other observable inputs. As of December 31, 2012, the Company's financial assets valued based on Level 1 inputs consisted of cash and cash equivalents in a money market fund and its financial assets valued based on Level 2 inputs consisted of high-grade corporate and commercial paper. During the year ended December 31, 2012, there were no transfers of financials assets between Levels 1 and 2. As of December 31, 2012, the Company had no financial liabilities that were recorded at fair value on the balance sheet. The fair value of the Company's term loan obligations is determined using current applicable rates for similar instruments as of the balance sheet date. The carrying value of the Company's term loan obligations approximates fair value as the Company's interest rate yield is near current market rate yields. The Company's term loan obligations are Level 3 liabilities within the fair value hierarchy.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Property and Equipment</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Property, equipment and software is carried at cost and depreciated using the straight-line method over the estimated useful lives of the related assets, which range from three to five years. Leasehold improvements are amortized over the lesser of the lease term or estimated useful life. Repairs and maintenance costs are expensed as incurred.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Research and Development Costs</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Research and development costs are expensed as incurred. Research and development costs are comprised of costs incurred in performing research and development activities, including internal costs for salaries, benefits, facilities, research-related overhead and stock compensation, and external costs for payments to third party contract research organizations, investigative sites and consultants in connection with the Company's preclinical and clinical programs, costs associated with drug formulation and supply of drugs for clinical trials, and other external costs.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Patents</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Costs to secure and defend patents are expensed as incurred and are classified as general and administrative expense in the Company's consolidated statements of operations. Patent expenses were approximately $1.8 million, $2.3 million, and $1.9 million for the years ended December 31, 2012, 2011 and 2010, respectively.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Income Taxes</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company uses the liability method to account for income taxes. Deferred tax assets and liabilities are determined based on the expected future tax consequences of temporary differences between the Company's consolidated financial statement carrying amounts and the tax basis of assets and liabilities using enacted tax rates expected to be in effect in the years in which the differences are expected to reverse. A valuation allowance is provided to reduce the deferred tax assets to the amount that will more likely than not be realized.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        As of December 31, 2012 and 2011, the Company had no items that were considered to be uncertain tax items or accrued interest or penalties related to uncertain tax positions.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The tax years 2009 through 2012 remain open to examination by the major taxing jurisdictions to which the Company is subject.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Impairment of Long-Lived Assets</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company assesses the potential impairments of its long-lived assets whenever events or changes in circumstances indicate that an asset's carrying value may not be recoverable. If the carrying value exceeds the undiscounted future cash flows estimated to result from the use and eventual disposition of the asset, the Company writes down the asset to its estimated fair value. Management believes that no long-lived assets were impaired as of December 31, 2012 and 2011.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Revenue Recognition</b></font></p>
<ul>
<li style="list-style: none">
<p style="FONT-FAMILY: times"><font size="2"><b><i>Collaboration and License Agreements</i></b></font></p></li></ul>
<p style="FONT-FAMILY: times"><font size="2">        The Company's principal source of revenue to date has been generated primarily through its former collaborative research and development agreements with Roche and GSK, which included upfront license payments, development milestones, reimbursement of research and development costs, and potential profit sharing payments, commercial and sales-based milestones and royalties. The application of accounting rules requires subjective analysis and requires management to make estimates and assumptions about whether deliverables within multiple-element arrangements are separable from the other aspects of the contractual arrangement into separate units of accounting and to determine the fair value to be allocated to each unit of accounting.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        For multiple-element arrangements entered into or materially modified after January 1, 2011, the Company follows the provisions of ASU No. 2009-13</font> <font size="2"><i>Multiple-deliverable Revenue Arrangements (</i></font><font size="2">ASU No. 2009-13). This standard addresses the determination of the unit(s) of accounting for multiple-element arrangements and how the arrangement's consideration should be allocated to each unit of accounting.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Pursuant to this standard, each required deliverable is evaluated to determine if it qualifies as a separate unit of accounting. For the Company this determination includes an assessment as to whether the deliverable has "stand-alone value" to the customer separate from the undelivered elements. The arrangement's consideration is then allocated to each separate unit of accounting based on the relative selling price of each deliverable. The estimated selling price of each deliverable is determined using the following hierarchy of values: (i) vendor-specific objective evidence of fair value, (ii) third-party evidence of selling price, and (iii) the Company's best estimate of the selling price (BESP). The BESP reflects the Company's best estimate of what the selling price would be if the deliverable was regularly sold by it on a stand-alone basis. The Company expects, in general, to use BESP for allocating consideration to each deliverable in future collaboration agreements. In general, the consideration allocated to each unit of accounting is then recognized as the related goods or services are delivered limited to the consideration not contingent upon future deliverables.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        For multiple-element arrangements entered into prior to January 1, 2011 and not materially modified thereafter, the Company continued to apply its prior accounting policy with respect to such arrangements. Under this policy, in general, revenue from non-refundable, upfront fees related to intellectual property rights/licenses where the Company had continuing involvement was recognized ratably over the estimated period of ongoing involvement because there was no objective and reliable evidence of fair value for certain of the undelivered item to allow the delivered item to be considered a separate unit of accounting. This requirement with respect to the fair value of undelivered items was eliminated in the newly issued accounting standard. In general, the consideration with respect to the other deliverables was recognized when the goods or services were delivered.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company's deliverables under its former collaboration agreement with Roche, including the related rights and obligations, contractual cash flows and performance periods, are more fully described in Note 8. Certain of the deliverables were combined as a single unit of accounting.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The cash flows associated with the single unit of accounting from the research and development portions of the Company's collaborations were recognized as revenue using a time-based model. Under this model, cash flow streams were recognized as revenue over the estimated performance period. Upon achievement of milestones, as defined in the collaboration agreements, revenue was recognized to the extent the accumulated service time, if any, had occurred. The remainder was deferred and recognized as revenue ratably over the remaining estimated performance period. A change in the period of time expected to complete the deliverable was accounted for as a change in estimate on a prospective basis. Revenue was limited to amounts that were non-refundable and that the Company's collaborators were contractually obligated to pay to the Company.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Effective January 1, 2011, the Company adopted ASU No. 2009-13 which codified a method of revenue recognition that has been common practice. Under this method, contingent consideration from research and development activities that is earned upon the achievement of a substantive milestone is recognized in its entirety in the period in which the milestone is achieved. At the inception of each arrangement that includes milestone payments, the Company evaluates whether each milestone is substantive. This evaluation includes an assessment of whether (a) the consideration is commensurate with either (1) the entity's performance to achieve the milestone, or (2) the enhancement of the value of the delivered item(s) as a result of a specific outcome resulting from the entity's performance to achieve the milestone, (b) the consideration relates solely to past performance and (c) the consideration is reasonable relative to all of the deliverables and payment terms within the arrangement. The Company evaluates factors such as the scientific, clinical, regulatory, commercial and other risks that must be overcome to achieve the respective milestone, the level of effort and investment required and whether the milestone consideration is reasonable relative to all deliverables and payment terms in the arrangement in making this assessment. From the effective date of the adoption of this standard, the Company did not achieve any developmental, commercial or sales-based milestones pursuant to its research and collaboration agreement with Roche. Upon the effectiveness of the termination of the collaboration agreement with Roche on February 16, 2012, as more fully described in Note 8, the Company has no ongoing research and collaboration agreements under which milestones may be achieved.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Royalty revenues are based upon a percentage of net sales. Royalties from the sales of products will be recorded on the accrual basis when results are reliably measurable, collectibility is reasonably assured and all other revenue recognition criteria are met. Commercial and sales-based milestones, which are based upon the achievement of certain agreed-upon sales thresholds, will be recognized in the period in which the respective sales threshold is achieved and collectibility is reasonably assured.</font></p>
<p style="FONT-FAMILY: times"><font size="2"><b><i>Grant Revenue</i></b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        In March 2011, the Company received a grant from the Department of Defense, in the approximate amount of $1 million, for the development of STA-9584 in advanced prostate cancer. The Company conducted work on this study during the one year grant period from April 2011 through March 2012. Reimbursements were based on actual costs agreed upon in the proposal (salary, fringe benefits, overhead, and direct costs such as materials and subcontractors). The Company recognized $147,000 and $853,000 of grant revenue under this grant in the years ended December 31, 2012 and 2011, respectively.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In November 2010, the Company was awarded approximately $1.0 million in grants under the Patient Protection and Affordable Care Act. The Company recognized approximately $1.0 million of grant revenue under these grants in the year ended December 31, 2010.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Stock-Based Compensation</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        The Company recognizes stock-based compensation expense based on the fair value of stock options granted to employees, officers and directors. The Company uses the Black-Scholes option pricing model as it is the most appropriate valuation method for its option grants. The Black-Scholes model requires inputs for risk-free interest rate, dividend yield, volatility and expected lives of the options. Expected volatility was principally based upon the weighted average historical volatility data of the Company's common stock and the historical volatility data from several guideline public biotechnology companies similar in size and value to the Company that also have stock compensation plans with similar terms. The Company estimates the forfeiture rate based on historical data. Based on an analysis of historical forfeitures, the Company has applied a forfeiture rate of 10% to all options that vest upon completion of the first year of service following the date of grant. The analysis is re-evaluated at least annually and the forfeiture rate is adjusted as necessary. The risk-free rate for periods within the expected life of the option is based on the U.S. Treasury yield curve in effect at the time of the grant. The expected lives for options granted represent the period of time that options granted are expected to be outstanding. The Company uses the simplified method for determining the expected lives of options.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        For awards with graded vesting, the Company allocates compensation costs on a straight-line basis over the requisite service period. The Company amortizes the fair value of each option over each option's service period, which is generally the vesting period.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        Certain of the employee stock options granted by the Company are structured to qualify as incentive stock options (ISOs). Under current tax regulations, the Company does not receive a tax deduction for the issuance, exercise or disposition of ISOs if the employee meets certain holding requirements. If the employee does not meet the holding requirements, a disqualifying disposition occurs, at which time the Company may receive a tax deduction. The Company does not record tax benefits related to ISOs unless and until a disqualifying disposition is reported. In the event of a disqualifying disposition, the entire tax benefit is recorded as a reduction of income tax expense. The Company has not recognized any income tax benefit for the share-based compensation arrangement due to the fact that the Company does not believe it is more likely than not it will recognize any deferred tax assets from such compensation cost recognized in the current period.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Comprehensive Loss</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Comprehensive loss is defined as the change in equity of a business enterprise during a period from transactions, and other events and circumstances from non-owner sources. Changes in unrealized gains and losses on marketable securities represent the only difference between the Company's net loss and comprehensive loss.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        In the first quarter of 2012, the Company adopted ASU No. 2011-05,</font> <font size="2"><i>Comprehensive Income (Topic 220): Presentation of Comprehensive Income</i></font> <font size="2">(ASU No. 2011-05). ASU No. 2011-05 requires companies to present the components of net income and other comprehensive income either as one continuous statement or as two consecutive statements, eliminating the option to present components of other comprehensive income as part of the statement of changes in stockholders' equity. This update does not change the items which must be reported in other comprehensive income, how such items are measured or when they must be reclassified to net income. Upon adoption, the Company elected to present comprehensive income in two separate but consecutive statements as part of the consolidated financial statements included in this Annual Report on Form 10-K.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Segment Reporting</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Operating segments are determined based on the way management organizes its business for making operating decisions and assessing performance. The Company has only one operating segment, the discovery, development and commercialization of drug products.</font></p></div>
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'>
<p style="FONT-FAMILY: times"><font size="2"><b>Basic and Diluted Loss Per Common Share</b></font></p>
<p style="FONT-FAMILY: times"><font size="2">        Basic net loss per share is computed using the weighted average number of common shares outstanding during the period, excluding restricted stock that has been issued but is not yet vested. Diluted net loss per common share is computed using the weighted average number of common shares outstanding and the weighted average dilutive potential common shares outstanding using the treasury stock method. However, for the years ended December 31, 2012, 2011 and 2010, diluted net loss per share is the same as basic net loss per share as the inclusion of weighted average shares of unvested restricted common stock and common stock issuable upon the exercise of stock options would be anti-dilutive.</font></p>
<p style="FONT-FAMILY: times"><font size="2">        The following table summarizes outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive:</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="55"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="55"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="55"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Years Ended December 31,</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Common stock options</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,521,584</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,821,073</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,326,979</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Unvested restricted stock</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35,122</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">82,450</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">140,613</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
P3Y
P5Y
1800000
2300000
1900000
1000000
1000000
0.10
1
5821073
82450
5326979
140613
5521584
35122
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"> </p>
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>December 31, 2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Cost</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Unrealized<br />
gains</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Unrealized<br />
losses</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Fair<br />
value</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cash and cash equivalents:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cash and money market funds (Level 1)</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">81,512</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">81,512</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Marketable securities:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Corporate debt securities due within 1 year of date of purchase (Level 2)</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">19,085</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(1</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">19,087</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total cash, cash equivalents and marketable securities</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">100,597</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(1</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">100,599</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"> </p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="45"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="51"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="45"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>December 31, 2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Cost</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Unrealized<br />
gains</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Unrealized<br />
losses</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Fair<br />
value</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cash and cash equivalents:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cash and money market funds (Level 1)</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">25,326</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">25,326</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Government-sponsored entities and corporate debt securities due within 3 months of date of purchase (Level 2)</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">4,749</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">4,749</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total cash and cash equivalents</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">30,075</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">30,075</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Marketable securities:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Corporate debt securities due within 1 year of date of purchase (Level 2)</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">9,647</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">9,650</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total cash, cash equivalents and marketable securities</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">39,722</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">39,725</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
P3M
P1Y
25326000
4749000
30075000
3000
9647000
39722000
9650000
39725000
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 83.18%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 257px">
<p style="FONT-FAMILY: times"> </p>
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="64"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="64"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Laboratory equipment</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,531</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,468</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Leasehold improvements</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,939</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,847</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Computers and software</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,630</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,315</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Furniture and fixtures</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,170</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,135</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">21,270</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">20,765</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less accumulated depreciation and amortization</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(20,096</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(19,358</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,174</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,407</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
3000
12468000
4847000
2315000
1135000
20765000
12531000
4939000
2630000
1170000
21270000
19358000
20096000
738000
9000000
43000
16000
7700000
0.05
P10Y
P4Y
1902341
5521584
1799096
1776287
5821073
3091173
7.54
5.14
3.54
9.36
9.02
4.26
3.27
4.10
518000
278000
904000
82450
92571
45243
5.04
4.94
5.16
5.47
0.0248
0.0262
0.0111
P6Y3M
P6Y3M
P6Y3M
1.01
1.02
1.01
2951000
403000
3354000
3614000
434000
4048000
2494000
860000
3074000
974000
2485000
837000
3082000
240000
3322000
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 88.21%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 227px">
<p style="FONT-FAMILY: times"> </p>
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="59"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="44"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="54"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Shares</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br />
average<br />
exercise<br />
price</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br />
average<br />
remaining<br />
contractual<br />
life (years)</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Aggregate<br />
intrinsic<br />
value</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at January 1</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,821,073</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7.54</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Options granted</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,799,096</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5.14</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Options exercised</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(322,298</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3.54</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Options cancelled</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,776,287</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">9.36</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at December 31</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,521,584</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.40</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.83</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">17,472,889</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Exercisable at December 31</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,091,173</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7.44</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5.25</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,906,822</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"> </p>
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="44"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="50"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Shares</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br />
average<br />
grant date<br />
fair value</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at January 1</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">82,450</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4.94</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Vested</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(92,571</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5.16</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Granted</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">45,243</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5.47</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at December 31</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35,122</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5.04</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 83.19%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 193px">
<p style="FONT-FAMILY: times"> </p>
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="15"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="58"></td>
<td style="FONT-FAMILY: times" width="15"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="58"></td>
<td style="FONT-FAMILY: times" width="15"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="58"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Years ended December 31,</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Risk-free interest rate</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1.11</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2.48</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2.62</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expected life in years</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.25 years</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.25 years</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.25 years</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Volatility</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">101</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">101</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">102</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expected dividend yield</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<p style="FONT-FAMILY: times"><font size="2">Stock-based compensation expense during the years ended December 31, 2012, 2011 and 2010 was as follows (in thousands):</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 86.93%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 280px">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="39"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="39"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="39"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Years ended December 31,</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Stock-based compensation expense by type of award:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Employee stock options</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,082</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,951</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,614</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Restricted stock</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">240</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">403</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">434</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total stock-based compensation expense</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,322</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,354</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">4,048</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Effect of stock-based compensation expense by line item:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Research and development</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,485</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,494</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,074</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">General and administrative</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">837</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">860</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">974</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total stock-based compensation expense included in net loss</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,322</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,354</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">4,048</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<p style="FONT-FAMILY: times"><font size="2">Unrecognized stock-based compensation expense as of December 31, 2012 was as follows (in thousands):</font></p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 77.79%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 160px">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="64"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="49"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Unrecognized<br />
stock<br />
compensation<br />
expense as of<br />
December 31,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br />
average<br />
remaining<br />
period<br />
(in years)</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Employee stock options</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,747</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2.65</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Restricted stock</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">172</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.62</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,919</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2.61</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
16000000
P2Y
21200000
2100000
6700000
4600000
0
0
9300000
0
-16109000
-2379000
84000
2867000
373000
1537000
259000
16442000
-12739000
-1967000
196000
3820000
791000
1686000
-78000
11663000
-21349000
-3220000
3167000
382000
411000
22000
21409000
16796000
2776000
667000
148779000
148779000
17225000
2594000
1014000
170189000
170189000
16400000
11700000
21400000
372000
429000
376000
1143000
1143000
1143000
3302000
1143000
1143000
1143000
3302000
211000
521000
121000
1143000
1354000
1664000
3423000
9436000
10417000
10751000
10859000
2803000
3131000
2946000
2673000
12109000
13363000
13882000
13662000
-10966000
-12009000
-12218000
-10239000
-11401000
-12502000
-12734000
-10743000
-0.27
-0.26
-0.26
-0.22
42008818
47845315
49403589
49426806
1
7191731
4.89
34800000
120000
120000
4.40
P1Y
81512000
25326000
100599000
100597000
3000
3000
30075000
322298
6.40
35122
7747000
P2Y7M24D
172000
P7M13D
7919000
P2Y7M10D
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"> </p>
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>Three Months Ended</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>March 31,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>June 30,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>September 30,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>(in thousands, except shares and per share data)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Revenues:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">License and milestone revenue</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cost sharing reimbursements, net</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total collaboration revenues</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Grant revenue</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">147</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total revenues</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">147</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Operating expenses:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Research and development</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">12,066</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">11,252</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">11,743</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">14,351</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">General and administrative</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,646</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,882</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,796</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,352</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total operating expenses</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">14,712</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">14,134</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">14,539</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">17,703</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Loss from operations</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(14,565</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(14,134</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(14,539</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(17,703</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Interest expense, net</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(486</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(486</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(457</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(420</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net loss</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(15,051</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(14,620</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(14,996</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(18,123</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Basic and diluted net loss per common share</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.27</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.25</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.25</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.29</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Basic and diluted weighted average number of common shares outstanding</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">56,366,992</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">57,650,412</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">60,661,720</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">62,914,546</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
<p style="FONT-FAMILY: times"><font size="2"><br /></font> </p>
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative">
<p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p>
<!-- User-specified TAGGED TABLE -->
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="68"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>Three Months Ended</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>March 31,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>June 30,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>September 30,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br />
2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="11"><font size="1"><b>(in thousands, except shares and per share data)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Revenues:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">License and milestone revenue</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,302</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cost sharing reimbursements, net</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total collaboration revenues</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,302</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Grant revenue</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">211</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">521</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">121</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total revenues</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,143</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,354</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">1,664</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,423</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Operating expenses:</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Research and development</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">9,436</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">10,417</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">10,751</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">10,859</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">General and administrative</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,673</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,946</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">3,131</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">2,803</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total operating expenses</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">12,109</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">13,363</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">13,882</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">13,662</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Loss from operations</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(10,966</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(12,009</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(12,218</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(10,239</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Interest expense, net</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(435</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(493</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(516</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(504</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net loss</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(11,401</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(12,502</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(12,734</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(10,743</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="white">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Basic and diluted net loss per common share</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.27</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.26</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.26</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">(0.22</font></td>
<td style="FONT-FAMILY: times"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Basic and diluted weighted average number of common shares outstanding</font></p></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">42,008,818</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">47,845,315</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">49,403,589</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" align="right"><font size="2">49,426,806</font></td>
<td style="FONT-FAMILY: times"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
147000
147000
12066000
11252000
11743000
14351000
2646000
2882000
2796000
3352000
14712000
14134000
14539000
17703000
-14565000
-14134000
-14539000
-17703000
-15051000
-14620000
-14996000
-18123000
56366992
57650412
60661720
62914546
-0.27
-0.25
-0.25
-0.29
13200000
6100000
400200000
157800000
60000000
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 85.88%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 3px">
<p style="FONT-FAMILY: times"> </p>
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="56"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="56"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Deferred tax assets:</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Federal and state net operating loss carryforwards</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">143,988</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">123,463</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Federal and state research and experimentation credits</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">17,225</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">16,796</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Depreciation and amortization</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,594</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,776</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Deferred compensation</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,368</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,077</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Other</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,014</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">667</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Deferred tax assets</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">170,189</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">148,779</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less valuation allowance</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(170,189</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(148,779</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net deferred tax assets</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 82.88%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 307px">
<p style="FONT-FAMILY: times"> </p>
<div align="center">
<table cellspacing="0" cellpadding="0" width="100%" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="50"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="50"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="50"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Years ended December 31,</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>(in thousands)</b></font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Provision (benefit) at statutory rate</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(21,349</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(16,109</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(12,739</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">State taxes, net of federal benefit</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(3,220</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(2,379</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,967</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">State tax rate change</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">84</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">196</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">State net operating loss expiration</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,167</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,867</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,820</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Stock-based compensation</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">382</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">373</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">791</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Tax credits</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(411</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,537</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,686</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Other</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">22</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">259</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(78</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">(Decrease) increase in valuation allowance</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">21,409</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">16,442</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,663</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Income tax provision (benefit)</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">—</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top">
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td>
<td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td>
<td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div></div>
P6Y9M29D
P5Y3M
17472889
7906822
321000
81512000
4749000
19085000
19087000
57000
1000
1400000
2000000
53544000
1141000
1141000
53545000
3322000
3322000
44155000
31310000
P3M
1000
23213000
23214000
1000
27101000
27102000
1000
65106000
65107000
5616667
5610238
11264102
9.02
856000
611000
123463000
143988000
5077000
5368000
1459000
96000
1581493
1136363
100600000
7000000
8.60
59800000
3976702
6.49
25800000
35200000
35400000
8050000
7000000
1050000
33000000
7.44
2649535
81512000
30075000
19087000
9650000
786000
561000
101385000
40286000
1174000
1407000
458000
631000
103017000
42324000
5661000
3467000
4761000
2841000
5127000
4594000
13000
12000
7924000
4234000
23486000
15148000
1000
14000
4464000
12388000
4465000
12402000
27951000
27550000
7000
5000
536277000
413196000
2000
3000
-461220000
-398430000
75066000
14774000
103017000
42324000
6731000
4572000
9253000
6731000
13825000
147000
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978000
147000
7584000
14803000
49412000
41464000
40252000
11676000
11552000
11449000
61088000
53016000
51701000
-60941000
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-1849000
-1948000
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-62790000
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-1.06
-1.00
-0.93
59411476
47197572
40365215
-1000
6000
-3000
-62791000
3322000
-116000
116000
225000
130000
12000
-173000
265000
8000
2194000
1542000
-2032000
1920000
330000
412000
533000
400000
-310000
-6731000
-4647000
-54135000
-47300000
-38199000
50033000
40595000
505000
66248000
53545000
4234000
12000
1696000
7762600
1000
-1000
-62790000
32000
32000
-3969
32000
0.03
600000
36
<div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; FONT-SIZE: 10pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 82.28%; PADDING-TOP: 0pt; FONT-FAMILY: Times New Roman; POSITION: relative; HEIGHT: 6px">
<p style="FONT-FAMILY: times"> </p>
<div align="center">
<table style="WIDTH: 548px; HEIGHT: 2px" cellspacing="0" cellpadding="0" width="548" border="0">
<tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET -->
<td style="FONT-FAMILY: times" align="left"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="55"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="55"></td>
<td style="FONT-FAMILY: times" width="12"></td>
<td style="FONT-FAMILY: times" align="right" width="7"></td>
<td style="FONT-FAMILY: times" width="55"></td>
<td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Years Ended December 31,</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="bottom">
<th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th>
<th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th>
<th style="FONT-FAMILY: times"><font size="1"> </font></th></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Common stock options</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,521,584</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,821,073</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,326,979</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr>
<tr style="HEIGHT: 0px" valign="top" bgcolor="white">
<td style="FONT-FAMILY: times" valign="bottom">
<p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Unvested restricted stock</font></p></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35,122</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">82,450</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td>
<td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">140,613</font></td>
<td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div>
<!-- end of user-specified TAGGED TABLE --></div>
4.89
8.60
3969
114250
1000000
-47374000
-37470000
172000
8106329
35000000
28000000
0.06
P3Y
0.50
1136363
4.40
1100000
-435000
-493000
-516000
-504000
-486000
-486000
-457000
-420000
P1Y
1300000
1000
1000
1100000
500000
300000
600000
600000
200000
3