UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

o

Rule 13d-1(b)

o

Rule 13d-1(c)

x

Rule 13d-1(d)

CUSIP No. 87162T 20 6

1.

Names of Reporting Persons
Lan Bo Chen

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

o

3.

SEC Use Only

4.

Citizenship or Place of Organization
United States

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5.

Sole Voting Power
760,035

6.

Shared Voting Power
2,667,417

7.

Sole Dispositive Power
760,035

8.

Shared Dispositive Power
2,667,417

9.

Aggregate Amount Beneficially Owned by Each Reporting Person
3,427,452

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o

11.

Percent of Class Represented by Amount in Row (9)
10.1%

12.

Type of Reporting Person (See Instructions)
IN

CUSIP No. 87162T 20 6

1.

Names of Reporting Persons
Lin-Huey Chen

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

o

(b)

o

3.

SEC Use Only

4.

Citizenship or Place of Organization
United States

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5.

Sole Voting Power
2,004,016

6.

Shared Voting Power
1,423,436

7.

Sole Dispositive Power
2,004,016

8.

Shared Dispositive Power
1,423,436

9.

Aggregate Amount Beneficially Owned by Each Reporting Person
3,427,452

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o

11.

Percent of Class Represented by Amount in Row (9)
10.1%

12.

Type of Reporting Person (See Instructions)
IN

Item 1.

(a)

Name of Issuer
Synta Pharmaceuticals Corp.

(b)

Address of Issuer’s Principal Executive Offices
45 Hartwell Avenue

 Lexington, MA 02421

Item 2.

(a)

Name of Person Filing
(i)  Lan Bo Chen

(ii)  Lin-Huey Chen

(b)

Address of Principal Business Office or, if none, Residence
(i) 184 East Emerson Road

      Lexington, MA 02420

(ii) 184 East Emerson Road

      Lexington, MA 02420

(c)

Citizenship
(i) United States

(ii) United States

(d)

Title of Class of Securities
Common Stock, par value $0.0001 per share

(e)

CUSIP Number
87162T 20 6

Item 3.

If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

o

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).

(b)

o

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c)

o

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

(d)

o

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).

(e)

o

An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);

(f)

o

An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);

(g)

o

A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);

(h)

o

A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)

o

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

o

A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J);

(k)

o

Group, in accordance with § 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution:

Item 4.

Ownership

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(i) Lan Bo Chen

(a)

Amount beneficially owned:   

3,427,452 shares. Consists of 600,035 shares of common stock owned of record by Dr. Lan Bo Chen; 142,223 shares of common stock owned of record by LAJ Holdings LLC, the co-managers of which are Dr. Chen and his spouse, Lin-Huey Chen; 1,684,016 shares of common stock owned of record by the Wisteria Trust, the trustee of which is Dr. Chen’s spouse; 243,481 shares of common stock owned of record by the Ann Chen Trust, a co-trustee of which is Dr. Chen’s spouse; 243,481 shares of common stock owned of record by the Jane Chen Trust, a co-trustee of which is Dr. Chen’s spouse; 12,946 shares of common stock owned of record by the Chen Grandchildren’s Trust, a co-trustee of which is Dr. Chen’s spouse; 12,710 shares of common stock owned of record by the Alexander Chen Wu 2002 Irrevocable Trust, a co-trustee of which is Dr. Chen’s spouse; 8,560 shares of common stock owned of record by the Allison Chen Wu 2004 Irrevocable Trust, a co-trustee of which is Dr. Chen’s spouse; 160,000 shares of common stock owned by the Lan Bo Chen 2008 GRAT, of which Dr. Chen is the trustee; and 320,000 shares of common stock owned by the Lin-Huey Chen 2008 GRAT, of which Dr. Chen’s spouse is the trustee.

(b)

Percent of class:   

10.1%

(c)

Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote   

760,035

(ii)

Shared power to vote or to direct the vote    

2,667,417

(iii)

Sole power to dispose or to direct the disposition of   

760,035

(iv)

Shared power to dispose or to direct the disposition of   

2,667,417

(ii) Lin-Huey Chen

(a)

Amount beneficially owned:  

3,427,452 shares. Consists of 600,035 shares of common stock owned of record by Mrs. Chen’s spouse, Dr. Lan Bo Chen; 142,223 shares of common stock owned of record by LAJ Holdings LLC, of which Mrs. Chen and her spouse are co-managers; 1,684,016 shares of common stock owned of record by the Wisteria Trust, of which Mrs. Chen is the trustee; 243,481 shares of common stock owned of record by the Ann Chen Trust, of which Mrs. Chen is a co-trustee; 243,481 shares of common stock owned of record by the Jane Chen Trust, of which Mrs. Chen is a co-trustee; 12,946 shares of common stock owned of record by the Chen Grandchildren’s Trust, of which Mrs. Chen is a co-trustee; 12,710 shares of common stock owned of record by the Alexander Chen Wu 2002 Irrevocable Trust, of which Mrs. Chen is a co-trustee; 8,560 shares of common stock owned of record by the Allison Chen Wu 2004 Irrevocable Trust, of which Mrs. Chen is a co-trustee; 160,000 shares of common stock owned by the Lan Bo Chen 2008 GRAT, of which Mrs. Chen’s spouse is the trustee; and 320,000 shares of common stock owned by the Lin-Huey Chen 2008 GRAT, of which Mrs. Chen is the trustee.

(b)

Percent of class:    

10.1%

(c)

Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote  

2,004,016

(ii)

Shared power to vote or to direct the vote   

1,423,436

(iii)

Sole power to dispose or to direct the disposition of  

2,004,016

(iv)

Shared power to dispose or to direct the disposition of  

1,423,436

Item 5.

Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following   o.

Not Applicable

Item 6.

Ownership of More than Five Percent on Behalf of Another Person

Not Applicable

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person

Not Applicable

Item 8.

Identification and Classification of Members of the Group

Not Applicable

Item 9.

Notice of Dissolution of Group

Not Applicable

Item 10.

Certification

Not Applicable

Date:  February 13, 2009

/s/ Lan Bo Chen

Lan Bo Chen

Date:  February 13, 2009

/s/ Lin-Huey Chen

Lin-Huey Chen