Meeting: IASLC 14th Annual Targeted Therapies of the Treatment of
Lung Cancer Meeting in
Title: “Hsp90i-Drug Conjugates (HDC) New Platform”
Date and Time:
Meeting: Applied Pharmaceutical Chemistry 2014 in
Title: “Hsp90-Inhibitor Drug Conjugates (HDCs): An Innovative Drug Delivery Platform Technology”
Date and Time:
About Hsp90-Inhibitor Drug Conjugates (HDCs)
HDCs are small-molecule drugs consisting of an Hsp90 inhibitor (targeting moiety) joined to an anti-cancer agent (payload) via a cleavable chemical linker optimized for controlled release of payload drug inside cancer cells. They exploit the preferential retention of Hsp90 inhibitors in tumors to selectively deliver anti-cancer payloads. HDCs represent a promising new therapeutic class with the potential to enhance the safety and efficacy of a wide range of small molecule anti-cancer drugs. Advantages relative to other tumor targeting strategies, such as antibody-drug conjugates (ADCs), include use of an intracellular target that is widely shared across cancer types, increased flexibility in the range of compatible payloads and linkers, and small molecule cellular uptake.
Synta has established proof of concept for HDC lead candidates in preclinical studies and has developed over 450 compounds, using a broad range of Hsp90 inhibitor moieties, cleavable linkers, and anti-cancer payloads. The latter include cytotoxic chemotherapeutics, kinase inhibitors, hormone therapies, immunomodulators, and epigenetic modifiers, creating the potential for next-generation compounds in each of these categories. Synta has filed worldwide patent applications that include comprehensive claims covering the HDC platform, compositions of matter, methods for identifying therapeutically effective compounds, and methods of use of such compounds against a wide range of diseases and conditions.
Synta Pharmaceuticals Corp.
Mindy Kohl, 781-541-7213
Andrea Rabney, 212-600-1494
Eliza Schleifstein, 917-763-8106