SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13D
Under the Securities Exchange Act of 1934

(Amendment No. 4)

Synta Pharmaceuticals Corp.
(Name of Issuer)

Common Stock
(Title of Class of Securities)

87162T206
(CUSIP Number)

Mr. Scott B. Bernstein
Caxton Corporation
731 Alexander Road, Bldg. 2
Princeton, New Jersey 08540
(609) 419-1800
(Name, Address and Telephone Number of Person Authorized to
Receive Notices and Communications)                                  

6/29/2012
(Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to
report the acquisition that is the subject of this Schedule 13D, and is
filing this schedule because of Section 240.13d-1(e), 240.13d-1(f) or
240.13d-1(g), check the following box. | |

Note:  Schedules filed in paper format shall include a signed original and
five copies of the schedule, including all exhibits.  See Section
240.13d-7 for other parties to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information
which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

CxSynta LLC
02-0604347

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
WC

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
Delaware

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
0

(8) Shared Voting Power:
7,761,716

(9) Sole Dispositive Power:
0

(10) Shared Dispositive Power:
7,761,716

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
7,761,716

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
13.5%

(14) Type of Reporting Person (See Instructions).
OO

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Caxton Corporation
22-2437619

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
AF

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
Delaware

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
0

(8) Shared Voting Power:
7,761,716

(9) Sole Dispositive Power:
0

(10) Shared Dispositive Power:
7,761,716

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
7,761,716

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
13.5%

(14) Type of Reporting Person (See Instructions).
CO

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Kovner 2011-A Investment Trust

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
OO

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
New York

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
125,000

(8) Shared Voting Power:
0

(9) Sole Dispositive Power:
125,000

(10) Shared Dispositive Power:
0

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
125,000

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
0.2%

(14) Type of Reporting Person (See Instructions).
OO

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Kovner 2011-B Investment Trust

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
OO

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
New York

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
125,000

(8) Shared Voting Power:
0

(9) Sole Dispositive Power:
125,000

(10) Shared Dispositive Power:
0

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
125,000

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
0.2%

(14) Type of Reporting Person (See Instructions).
OO

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Kovner 2011-C Investment Trust

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
OO

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
New York

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
125,000

(8) Shared Voting Power:
0

(9) Sole Dispositive Power:
125,000

(10) Shared Dispositive Power:
0

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
125,000

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
0.2%

(14) Type of Reporting Person (See Instructions).
OO

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Kovner 2011-D Investment Trust

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
OO

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
New York

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
125,000

(8) Shared Voting Power:
0

(9) Sole Dispositive Power:
125,000

(10) Shared Dispositive Power:
0

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
125,000

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
0.2%

(14) Type of Reporting Person (See Instructions).
OO

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Kovner 2012-A Synta Investment Trust

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
OO

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
New York

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
0

(8) Shared Voting Power:
475,000

(9) Sole Dispositive Power:
0

(10) Shared Dispositive Power:
475,000

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
475,000

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
0.8%

(14) Type of Reporting Person (See Instructions).
OO

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Kovner 2012-B Synta Investment Trust

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
OO

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
New York

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
0

(8) Shared Voting Power:
475,000

(9) Sole Dispositive Power:
0

(10) Shared Dispositive Power:
475,000

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
475,000

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
0.8%

(14) Type of Reporting Person (See Instructions).
OO

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Kovner 2012-C Synta Investment Trust

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
OO

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
New York

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
0

(8) Shared Voting Power:
475,000

(9) Sole Dispositive Power:
0

(10) Shared Dispositive Power:
475,000

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
475,000

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
0.8%

(14) Type of Reporting Person (See Instructions).
OO

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Kovner 2012-D Synta Investment Trust

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
OO

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
New York

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
0

(8) Shared Voting Power:
475,000

(9) Sole Dispositive Power:
0

(10) Shared Dispositive Power:
475,000

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
475,000

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
0.8%

(14) Type of Reporting Person (See Instructions).
OO

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Ben-Ur, David

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
PF

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
United States

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
2,700

(8) Shared Voting Power:
0

(9) Sole Dispositive Power:
2,700

(10) Shared Dispositive Power:
0

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
2,700

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
0.0%

(14) Type of Reporting Person (See Instructions).
IN

(1) Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Kovner, Bruce

(2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
(b)|x|

(3) SEC Use Only.

(4) Source of Funds (See Instructions).
AF,PF

(5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
2(d) or 2(e)  |_|

(6) Citizenship or Place of Organization
United States

Number of Shares Beneficially Owned by Each Reporting Person With:

(7) Sole Voting Power:
5,001,875

(8) Shared Voting Power:
9,661,716

(9) Sole Dispositive Power:
5,001,875

(10) Shared Dispositive Power:
9,661,716

(11) Aggregate Amount Beneficially Owned by Each Reporting Person.
14,663,591

(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares 
(see instructions).  |_|

(13) Percent of Class Represented by Amount in Row (11).
25.4%

(14) Type of Reporting Person (See Instructions).
IN

Item 3.  Source and Amount of Funds or Other Consideration

Item 3 is hereby amended by adding the following thereto:

Mr. Kovner has expended, in aggregate, approximately $36,763,958 
(excluding commissions, if any) to acquire 7,272,816 shares of
Synta Pharmaceuticals Corp.  The purchase price for the shares of 
Common Stock acquired by Mr. Kovner was paid out of Mr. Kovner's 
personal funds.  52,372 of the outstanding shares of Common Stock 
directly owned by Mr. Kovner were issued to Mr. Kovner as 
compensation for his service on the Company's Board of Directors
or certain of its committees.  Mr. Kovner also was granted
76,687 options on the Common Stock of the Company as compensation in
connection with his service on the Company's Board of Directors.

Mr. David Ben-Ur has expended, in aggregate, approximately
$14,678 (excluding commissions) to acquire 2,700 shares of the
Company.

Each of the trusts listed herein have received their respective
shares of Common Stock of the Company as gifts from Mr. Kovner.

Item 5.  Interest in Securities of the Issuer

Subparagraph (a), (b) and (c) of Item 5 of the Schedule 13D is 
hereby amended and replaced by the following:

(a)  (i) CxSynta LLC beneficially owns 7,761,716 shares of Common Stock, 
representing approximately 13.5% of the 57,639,108 shares of Common 
Stock reported to be outstanding as of April 30, 2012, as reported 
in the Company's Form 10-Q filed with the Securities Exchange 
Commission on May 3, 2012. The percentages used herein and in the 
rest of this Amendment No. 4 are calculated based upon such number 
of outstanding shares.

(ii) Caxton Corporation is the managing member of CxSynta LLC and as
such, has voting and dispositive power with respect to the 7,761,716 
shares beneficially owned by CxSynta LLC.  As a result, Caxton 
Corporation may be deemed to beneficially own 7,761,716 shares of 
Common Stock, representing approximately 13.5% of the total shares 
of Common Stock issued and outstanding.

(iii) Kovner 2011-A Investment Trust beneficially owns 125,000 shares
of Common Stock, representing approximately 0.2% of the total shares of
Common Stock issued and outstanding.

(iv)  Kovner 2011-B Investment Trust beneficially owns 125,000 shares
of Common Stock, representing approximately 0.2% of the total shares of
Common Stock issued and outstanding.

(v)   Kovner 2011-C Investment Trust beneficially owns 125,000 shares
of Common Stock, representing approximately 0.2% of the total shares of
Common Stock issued and outstanding.

(vi)  Kovner 2011-D Investment Trust beneficially owns 125,000 shares
of Common Stock, representing approximately 0.2% of the total shares of
Common Stock issued and outstanding.

(vii) Kovner 2012-A Synta Investment Trust beneficially owns 475,000 
shares of Common Stock, representing approximately 0.8% of the total 
shares ofCommon Stock issued and outstanding.

(viii)Kovner 2012-B Synta Investment Trust beneficially owns 475,000 
shares of Common Stock, representing approximately 0.8% of the total 
shares ofCommon Stock issued and outstanding.

(ix)  Kovner 2012-C Synta Investment Trust beneficially owns 475,000 
shares of Common Stock, representing approximately 0.8% of the total 
shares of Common Stock issued and outstanding.

(x)   Kovner 2012-D Synta Investment Trust beneficially owns 475,000 
shares of Common Stock, representing approximately 0.8% of the total 
shares of Common Stock issued and outstanding.

(xi) Mr. Ben-Ur is the Chief Investment Officer of Caxton Alternative 
Management LP and has sole beneficial ownership of 2,700 shares of 
Common Stock, representing approximately 0.0% of the total shares of 
Common Stock issued and outstanding.

(xii) Mr. Kovner has sole beneficial ownership of 5,001,875 shares of 
Common Stock, which includes options to purchase 76,687 shares of 
Common Stock upon the exercise of such options.  In addition, Mr. Kovner
is the Chairman and sole shareholder of Caxton Corporation, the managing 
member of CxSynta LLC, and as a result may be deemed to beneficially 
own the securities of the Company owned by CxSynta LLC.  Mr. Kovner is 
the sole trustee of each of the following trusts and as a result may be 
deemed to beneficially own the 1,900,000 securities of the Company owned
by such trusts in aggregate: Kovner 2012-A Synta Investment Trust; Kovner 
2012-B Synta Investment Trust; Kovner 2012-C Synta Investment Trust; and
Kovner 2012-D Synta Investment Trust.  Mr. Kovner disclaims beneficial 
ownership of the shares of Common Stock owned directly by CxSynta LLC 
except to the extent of his pecuniary interest therein.  Mr. Kovner 
also disclaims beneficial ownership of the shares of Common Stock directly
owned by such trusts. As a result of the foregoing, Mr. Kovner may be
deemed to beneficially own an aggregate of 14,663,591 shares of Common
Stock, representing approximately 25.4% of the total shares of Common
Stock issued and outstanding.

(b)   Caxton Corporation and Mr. Kovner, as Chairman and sole shareholder of 
Caxton Corporation, the managing member of CxSynta LLC, may be deemed to
share voting and dispositive power over 7,761,716 shares of Common Stock
owned directly by CxSynta LLC.  Cadence Trust Company, the Trustee of 
each of the following trusts, has sole voting and dispositive power 
over the aggregate 500,000 shares of Common Stock owned directly 
by each of such Trusts:  Kovner 2011-A Investment Trust, Kovner 
2011-B Investment Trust, Kovner 2011-C Investment Trust, and Kovner 
2011-D Investment Trust.  While Mr. Kovner is a director of Cadence Trust 
Company and, as such, may be deemed to not have beneficial ownership over 
the shares of the Company held by the trusts for which Cadence Trust
Company serves as Trustee, disclosure of such relationship and ownership
is being made herein. Mr. Ben-Ur has sole voting and dispositive power 
over the 2,700 shares of Common Stock owned directly by him.  Mr. Kovner
also may be deemed to share voting and dispositive power with respect to
the 1,900,000 shares of Common Stock of the Company that are owned by 
each of the following trusts, as Mr. Kovner is the Trustee of such 
Trusts:  Kovner 2012-A Synta Investment Trust, Kovner 2012-B Synta 
Investment Trust, Kovner 2012-C Synta Investment Trust, and Kovner 
2012-D Synta Investment Trust.  In addition, Mr. Kovner has sole 
voting and dispositive power with respect to the 5,001,875 shares of 
Common Stock which he directly beneficially owns.

(c)   On June 29, 2012, Mr. Kovner purchased 910,000 shares of Common Stock 
at a weighted average purchase price of $5.4498 per share.  On June 29, 
2012, Mr. Ben-Ur purchased 2,700 shares of Common Stock of the Company
at an average cost of $5.45.  On June 29, 2012, Mr. Kovner transferred,
as gifts, 475,000 shares of Common Stock of the Company to each of the
following trusts (for an aggregate 1,900,000 shares of Common Stock of
the Company):  Kovner 2012-A Synta Investment Trust, Kovner 2012-B Synta
Investment Trust, Kovner 2012-C Synta Investment Trust, and Kovner 2012-D
Synta Investment Trust.  On July 1, 2012, Mr. Kovner received shares of
Common Stock of the Company in the amounts of (a) 7,312, (b) 914, and
(c) 914, and 10,000 options on Common Stock of the Company, as 
compensation for his service on the Company's Board of Directors or on
certain of its committees.  

Except as reported in this statement on Schedule 13D, the Reporting
Persons are not believed to have engaged in any other transactions in the
Company's securities in the past sixty (60) days.

Item 6.  Contracts, Arrangements, Understandings or Relationships 
with Respect to Securities of the Issuer.

Item 6 is hereby amended by adding the following thereto:

The information contained in Item 5 of this Amendment No.4 is
incorporated by reference.

Mr. Ben-Ur serves as Chief Investment Officer of Caxton Alternative 
Management LP, an entity indirectly controlled by Mr. Kovner and as such 
has agreed, during the course of his employment with Caxton Alternative 
Management LP, to abide by certain policies and procedures applicable to 
Mr. Kovner as a director of the Company.  By reason of this agreement, 
Mr. Kovner and Mr. Ben-Ur may be deemed to be members of a group. 
Mr. Kovner, Mr. Ben-Ur and all other Reporting Persons named herein, 
expressly disclaim beneficial ownership of the Common Stock of the other 
Reporting Persons except to the extent they may have an interest in such 
other Reporting Person.

Except as set forth above, there are no contracts, arrangements, 
understandings or relationships (legal or otherwise) among the persons 
filing this Report or the Listed Persons or between such persons and 
any other person with respect to any securities of the Company, 
including, but not limited to transfer or voting of any of the 
securities, finder's fees, joint ventures, loan or option 
arrangements, puts or calls, guarantees of profits, division of profits 
or losses, or the giving or withholding of proxies.

Item 7.  Material to Be Filed as Exhibits

Signature     

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

CxSynta LLC

Date: 07/03/2012                        By Caxton Corporation, Managing Member 
of CxSynta LLC, 
by /s/ Scott B. Bernstein, 
Secretary of Caxton Corporation 

Caxton Corporation

Date: 07/03/2012                        /s/ Scott B. Bernstein, Secretary of 
Caxton Corporation

Date: 07/03/2012                        Kovner 2011-A Investment Trust

/s/ Peter P. D'Angelo, President of
Cadence Trust Company, Trustee

Date: 07/03/2012                        Kovner 2011-B Investment Trust

/s/ Peter P. D'Angelo, President of
Cadence Trust Company, Trustee

Date: 07/03/2012                        Kovner 2011-C Investment Trust

/s/ Peter P. D'Angelo, President of
Cadence Trust Company, Trustee

Date: 07/03/2012                        Kovner 2011-D Investment Trust

/s/ Peter P. D'Angelo, President of
Cadence Trust Company, Trustee

Date: 07/03/2012                        Kovner 2012-A Synta Investment Trust

/s/ Bruce S. Kovner, Trustee

Date: 07/03/2012                        Kovner 2012-B Synta Investment Trust

/s/ Bruce S. Kovner, Trustee

Date: 07/03/2012                        Kovner 2012-C Synta Investment Trust

/s/ Bruce S. Kovner, Trustee

Date: 07/03/2012                        Kovner 2012-D Synta Investment Trust

/s/ Bruce S. Kovner, Trustee

Date: 07/03/2012                        David Ben-Ur
/s/ David Ben-Ur

Bruce S. Kovner
Date: 07/03/2012                        /s/ Bruce S. Kovner             

The original statement shall be signed by each person on whose behalf the
statement is filed or his authorized representative. If the statement is 
signed on behalf of a person by his authorized representative (other than 
an executive officer or general partner of the filing person), evidence of
the representative's authority to sign on behalf of such person shall be 
filed with the statement: provided, however, that a power of attorney for 
this purpose which is already on file with the Commission may be incorporated 
by reference.  The name and any title of each person who signs the statement 
shall be typed or printed beneath his signature.

ATTENTION: Intentional misstatements or omissions of fact constitute Federal
criminal violations (See 18 U.S.C. 1001).